Jules TRITSCHLER
@jules-tritschler.bsky.social
PhD candidate exploring the diversity of vesicles released by the neutrophil during Shigella infection 🔬
Team Pathogenesis of bacterial infections and immunity directed by Benoit Marteyn at IBMC in Strasbourg 🦠
Keywords : Neutrophil, EV, GAG, trafficking
Team Pathogenesis of bacterial infections and immunity directed by Benoit Marteyn at IBMC in Strasbourg 🦠
Keywords : Neutrophil, EV, GAG, trafficking
Reposted by Jules TRITSCHLER
Thrilled to share that neutrophils produce extra long fibrillar components named proteoglycofili or PGF. PGF are released by living neutrophils and do not contain DNA. They might look like NETs but are not NETs…
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria
Alternative to the formation of NETs, André et al. describe here that viable neutrophils
may release a fibrillar component named proteoglycofili or PGF upon stimulation. PGF
formation is associated wi...
www.cell.com
November 27, 2025 at 9:01 PM
Thrilled to share that neutrophils produce extra long fibrillar components named proteoglycofili or PGF. PGF are released by living neutrophils and do not contain DNA. They might look like NETs but are not NETs…
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Jules TRITSCHLER
Reposted by Jules TRITSCHLER
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Reposted by Jules TRITSCHLER
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Jules TRITSCHLER
Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation!
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM
September 19, 2025 at 7:42 AM
Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation!
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM
Reposted by Jules TRITSCHLER
This is another must read - great week for organelle bio tools this week!
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 6:26 PM
This is another must read - great week for organelle bio tools this week!
Reposted by Jules TRITSCHLER
Tour de force from @nadlerlab.bsky.social . The value of solving a hard problem with beautiful chemistry: insights that upend conventional thinking re: lipid transport. You’ve got to read the thread, I’m not giving away the juice! It’s fantastic! Congrats 🎈🎊🍾🎉
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 31, 2025 at 2:11 PM
Tour de force from @nadlerlab.bsky.social . The value of solving a hard problem with beautiful chemistry: insights that upend conventional thinking re: lipid transport. You’ve got to read the thread, I’m not giving away the juice! It’s fantastic! Congrats 🎈🎊🍾🎉
Reposted by Jules TRITSCHLER
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
Reposted by Jules TRITSCHLER
🍹Sharma, Jiao et al. report glycosylation of small RNAs within #exosomes and propose a glycosylation-dependent mechanism for #RNA targeting into exosomes, which may influence intercellular communication and RNA stability in the extracellular environment.
👉https://rdcu.be/eykKY
bit.ly/455vyuP
👉https://rdcu.be/eykKY
bit.ly/455vyuP
Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology
Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...
bit.ly
July 29, 2025 at 12:07 PM
🍹Sharma, Jiao et al. report glycosylation of small RNAs within #exosomes and propose a glycosylation-dependent mechanism for #RNA targeting into exosomes, which may influence intercellular communication and RNA stability in the extracellular environment.
👉https://rdcu.be/eykKY
bit.ly/455vyuP
👉https://rdcu.be/eykKY
bit.ly/455vyuP
Reposted by Jules TRITSCHLER
Fascinating observation of LC3-tagging of extracellular Shigella by neutrophils, both in vitro and in vivo. Well done Jūratė !
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Neutrophils display antibacterial defense via non-canonical LC3 decoration of extracellular bacteria
Neutrophils play a pivotal role in the innate immune response to bacterial infection, being one of the first immune cells to reach infectious sites. B…
www.sciencedirect.com
July 15, 2025 at 7:35 AM
Fascinating observation of LC3-tagging of extracellular Shigella by neutrophils, both in vitro and in vivo. Well done Jūratė !
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jules TRITSCHLER
STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch https://www.biorxiv.org/content/10.1101/2025.05.29.656564v1
May 30, 2025 at 7:30 AM
STARD3 coordinates Endoplasmic Reticulum-late endosome/lysosome contacts and organelle positioning through a GSK3-regulated phosphorylation switch https://www.biorxiv.org/content/10.1101/2025.05.29.656564v1
Reposted by Jules TRITSCHLER
📘Read in #JExBio📘 Standard lab materials like borosilicate glass coverslips, with or without poly-L-lysine, can be effectively used for the immobilisation of EVs in specific imaging techniques. isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
May 15, 2025 at 8:07 AM
📘Read in #JExBio📘 Standard lab materials like borosilicate glass coverslips, with or without poly-L-lysine, can be effectively used for the immobilisation of EVs in specific imaging techniques. isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Jules TRITSCHLER
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
May 6, 2025 at 12:46 PM
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
Reposted by Jules TRITSCHLER
💥 New study : check out @katkajerabkova.bsky.social Katka's wizardry in the lab 🧙♂️
Building on the #Nanotumor consortium that we launched few years back, we now provide solid evidence that melanoma cells' inner architecture controls the progression of #melanoma to #metastasis
rdcu.be/eg8EU (1/3)
Building on the #Nanotumor consortium that we launched few years back, we now provide solid evidence that melanoma cells' inner architecture controls the progression of #melanoma to #metastasis
rdcu.be/eg8EU (1/3)
Peripheral positioning of lysosomes supports melanoma aggressiveness
Nature Communications - The function and position of organelles are pivotal for tumor cell dissemination. Here the authors use melanoma patient samples and animal models to show that peripheral...
rdcu.be
April 10, 2025 at 5:40 AM
💥 New study : check out @katkajerabkova.bsky.social Katka's wizardry in the lab 🧙♂️
Building on the #Nanotumor consortium that we launched few years back, we now provide solid evidence that melanoma cells' inner architecture controls the progression of #melanoma to #metastasis
rdcu.be/eg8EU (1/3)
Building on the #Nanotumor consortium that we launched few years back, we now provide solid evidence that melanoma cells' inner architecture controls the progression of #melanoma to #metastasis
rdcu.be/eg8EU (1/3)
Reposted by Jules TRITSCHLER
Dear #LipidDroplet friends, we are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava!
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
March 11, 2025 at 3:17 PM
Dear #LipidDroplet friends, we are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava!
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Abstract submission deadline is 10 June 2025.
@embo.org
@biologists.bsky.social
meetings.embo.org/event/25-lip...
Reposted by Jules TRITSCHLER
Groundbreaking discovery! For the first time, tunneling nanotubes (TNT) have been observed in a living organism.
This major step, led by Chiara Zurzolo's team at Institut Pasteur, could reshape our understanding of cell communication & disease spread.
🔗 Read more : www.pasteur.fr/en/research-...
This major step, led by Chiara Zurzolo's team at Institut Pasteur, could reshape our understanding of cell communication & disease spread.
🔗 Read more : www.pasteur.fr/en/research-...
March 10, 2025 at 9:45 AM
Groundbreaking discovery! For the first time, tunneling nanotubes (TNT) have been observed in a living organism.
This major step, led by Chiara Zurzolo's team at Institut Pasteur, could reshape our understanding of cell communication & disease spread.
🔗 Read more : www.pasteur.fr/en/research-...
This major step, led by Chiara Zurzolo's team at Institut Pasteur, could reshape our understanding of cell communication & disease spread.
🔗 Read more : www.pasteur.fr/en/research-...
Reposted by Jules TRITSCHLER
Des scientifiques, entre autres de l'Inserm, révèlent que les macrophages seraient capables de se fournir en nutriments directement via la dégradation des bactéries ingérées.
1/5
Lire le communiqué : presse.inserm.fr/les-macropha...
@cnrs.fr @univbordeaux.bsky.social
1/5
Lire le communiqué : presse.inserm.fr/les-macropha...
@cnrs.fr @univbordeaux.bsky.social
February 26, 2025 at 4:33 PM
Des scientifiques, entre autres de l'Inserm, révèlent que les macrophages seraient capables de se fournir en nutriments directement via la dégradation des bactéries ingérées.
1/5
Lire le communiqué : presse.inserm.fr/les-macropha...
@cnrs.fr @univbordeaux.bsky.social
1/5
Lire le communiqué : presse.inserm.fr/les-macropha...
@cnrs.fr @univbordeaux.bsky.social
Reposted by Jules TRITSCHLER
Saw the pre-print and was waiting for the publication for this one:
“Histones as #exosome membrane proteins regulated by cell stress.”
Exosomes contain mostly unmodified histones, distinct to their cellular counterparts.
Full paper in #JEV:
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
“Histones as #exosome membrane proteins regulated by cell stress.”
Exosomes contain mostly unmodified histones, distinct to their cellular counterparts.
Full paper in #JEV:
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress
Schematic diagram showing main features of EVs released under normal or stressed conditions. Stressed cells secrete more EVs that are smaller in size and contain more histones. EV histones are membra....
isevjournals.onlinelibrary.wiley.com
February 23, 2025 at 5:27 PM
Saw the pre-print and was waiting for the publication for this one:
“Histones as #exosome membrane proteins regulated by cell stress.”
Exosomes contain mostly unmodified histones, distinct to their cellular counterparts.
Full paper in #JEV:
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
“Histones as #exosome membrane proteins regulated by cell stress.”
Exosomes contain mostly unmodified histones, distinct to their cellular counterparts.
Full paper in #JEV:
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Jules TRITSCHLER
Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in the article below. www.nature.com/articles/s41...
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology
Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.
www.nature.com
February 21, 2025 at 4:38 PM
Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in the article below. www.nature.com/articles/s41...
Reposted by Jules TRITSCHLER
New mechanism for mass escape: The release of small extracellular vesicles from a larger membrane-enclosed structure can be described by a ‘torn bag’ mechanism.
https://buff.ly/41dU4cu
https://buff.ly/41dU4cu
February 18, 2025 at 9:01 PM
New mechanism for mass escape: The release of small extracellular vesicles from a larger membrane-enclosed structure can be described by a ‘torn bag’ mechanism.
https://buff.ly/41dU4cu
https://buff.ly/41dU4cu
Reposted by Jules TRITSCHLER
This week's #EVClub features "Direct intercellular vesicle exchange between adjacent cells"
www.biorxiv.org/content/10.1...
With Jun Yamashita and group
Wed Feb 19, 11 AM Japan, 10 AM Beijing, 1 PM Melbourne; Tuesday Feb 18, 9 PM EST
Need the login? www.surveymonkey.com/r/EVClubISEV
www.biorxiv.org/content/10.1...
With Jun Yamashita and group
Wed Feb 19, 11 AM Japan, 10 AM Beijing, 1 PM Melbourne; Tuesday Feb 18, 9 PM EST
Need the login? www.surveymonkey.com/r/EVClubISEV
February 17, 2025 at 3:59 PM
This week's #EVClub features "Direct intercellular vesicle exchange between adjacent cells"
www.biorxiv.org/content/10.1...
With Jun Yamashita and group
Wed Feb 19, 11 AM Japan, 10 AM Beijing, 1 PM Melbourne; Tuesday Feb 18, 9 PM EST
Need the login? www.surveymonkey.com/r/EVClubISEV
www.biorxiv.org/content/10.1...
With Jun Yamashita and group
Wed Feb 19, 11 AM Japan, 10 AM Beijing, 1 PM Melbourne; Tuesday Feb 18, 9 PM EST
Need the login? www.surveymonkey.com/r/EVClubISEV
Reposted by Jules TRITSCHLER
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted by Jules TRITSCHLER
Proud to have helped a student to graduate:
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles - Journal of Biological Chemistry www.jbc.org/article/S002...
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles - Journal of Biological Chemistry www.jbc.org/article/S002...
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles
Small extracellular vesicles (sEVs) are particles secreted from cells that play vital
roles both in normal physiology and in human disease. sEVs are highly enriched in
tetraspanin proteins, such as CD...
www.jbc.org
February 7, 2025 at 12:10 AM
Proud to have helped a student to graduate:
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles - Journal of Biological Chemistry www.jbc.org/article/S002...
Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles - Journal of Biological Chemistry www.jbc.org/article/S002...
Reposted by Jules TRITSCHLER
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
February 2, 2025 at 11:08 AM
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...