Jozefien Goethals
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joziegoethals.bsky.social
Jozefien Goethals
@joziegoethals.bsky.social
PhD Candidate Neurobiology VIB-KU Leuven Center for Brain & Disease Research 🧠🧬
Closing talk at #NHND25 by professor Charlotte Sumner about TRPV4 in motor neuron degeneration 🧫
October 10, 2025 at 3:38 PM
New day at #NHND25!
Professor Stephan Züchner presented his fascinating work on the genomic spectrum of repeat expansion loci and their growing associations with disease 🧠
October 10, 2025 at 10:16 AM
Professor @jeroenpasterkamp.bsky.social just presented his work at #NHND25 on modelling neurodegenerative diseases in a dish, showing new avenues in using organoids models in C9-ALS 🧫
October 9, 2025 at 10:14 AM
Professor Kathryn @bowleslab.bsky.social just presented her interesting work on profiling the impact of 4R tau on mitochondrial health and microtubule stability in organoids. She showed that different mutations increase 4R but differ in neuronal vulnerability and mitochondrial dysfunction #NHND25
October 9, 2025 at 9:46 AM
Professor @mancusorenzo.bsky.social just presented his new work at #NHD25.

Some of his key findings include:
• GRN LOF→ microglial overactivation and lysosomal failure
• Lysosomal failure → microglial degeneration eventually worsening neuropathology
October 9, 2025 at 8:30 AM