Joshua McGrath
@joshuamcgrath.bsky.social
Banting Postdoctoral Fellow at Weill Cornell Medicine | Antibodies, B cell Repertoires, Memory | PhD from McMaster University
Pinned
Joshua McGrath
@joshuamcgrath.bsky.social
· Dec 30
Mutability and hypermutation antagonize immunoglobulin codon optimality
McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.
www.cell.com
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Thanks @airr-community.bsky.social for the invitation to share our work on codon optimality in immunoglobulins!
www.cell.com/molecular-ce...
www.youtube.com/watch?v=WSku...
www.cell.com/molecular-ce...
www.youtube.com/watch?v=WSku...
AIRR C Seminar Series, June 26, 2025 Joshua McGrath, Weill Cornell Medicine, United States
YouTube video by AIRR Community
www.youtube.com
August 7, 2025 at 7:47 PM
Thanks @airr-community.bsky.social for the invitation to share our work on codon optimality in immunoglobulins!
www.cell.com/molecular-ce...
www.youtube.com/watch?v=WSku...
www.cell.com/molecular-ce...
www.youtube.com/watch?v=WSku...
Reposted by Joshua McGrath
The next AIRR-C seminar is scheduled for June 26 at 1600 CET, 1000 ET, 700 PT with Rohit Sing @rohitsingh8080.bsky.social (antibody PLMs) and @joshuamcgrath.bsky.social (immunoglobulin codon mutability). Register here: antibodysociety.org/the-airr-com...
AIRR Community Seminar Series - The Antibody Society
Join the AIRR Community for a 90 minute “lab-style” virtual seminar. Each month an established and an early career scientist will discuss their AIRR-seq related research. Seminar time will be 16:00 – ...
www.antibodysociety.org
June 12, 2025 at 3:02 PM
The next AIRR-C seminar is scheduled for June 26 at 1600 CET, 1000 ET, 700 PT with Rohit Sing @rohitsingh8080.bsky.social (antibody PLMs) and @joshuamcgrath.bsky.social (immunoglobulin codon mutability). Register here: antibodysociety.org/the-airr-com...
Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfC...
www.science.org
January 7, 2025 at 7:52 PM
Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Joshua McGrath
Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity
www.pnas.org/doi/10.1073/... @pnas.org
www.pnas.org/doi/10.1073/... @pnas.org
December 31, 2024 at 2:13 AM
Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity
www.pnas.org/doi/10.1073/... @pnas.org
www.pnas.org/doi/10.1073/... @pnas.org
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Mutability and hypermutation antagonize immunoglobulin codon optimality
McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.
www.cell.com
December 30, 2024 at 3:35 PM
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...