Joe Yesselman
@josephyesselman.bsky.social
RNA structural biologist, developing RNA-based nanomachines for therapeutic and biosensing applications. yesselmanlab.com
Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...
December 12, 2024 at 6:19 PM
Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...
It's great to see the latest RNA puzzles paper has come out.
www.nature.com/articles/s41...
Its a must-read for those interested in RNA structure prediction!
www.nature.com/articles/s41...
Its a must-read for those interested in RNA structure prediction!
RNA-Puzzles Round V: blind predictions of 23 RNA structures - Nature Methods
The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.
www.nature.com
December 3, 2024 at 4:58 PM
It's great to see the latest RNA puzzles paper has come out.
www.nature.com/articles/s41...
Its a must-read for those interested in RNA structure prediction!
www.nature.com/articles/s41...
Its a must-read for those interested in RNA structure prediction!
🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...
A quantitative framework for structural interpretation of DMS reactivity
Dimethyl sulfate (DMS) chemical mapping is widely used for probing RNA structure, with low reactivity interpreted as Watson-Crick (WC) base pairs and high reactivity as unpaired nucleotides. Despite i...
www.biorxiv.org
November 25, 2024 at 3:42 PM
🧬 Excited to share our new preprint! DMS chemical mapping, a key technique for studying RNA structure. Everyone assumes low DMS reactivity = Watson-Crick , high = non-WC. However, analyzing 7,500 RNA structures containing known 3D structures reveals it's not that simple. doi.org/10.1101/2024...
I hope this place is more positive and science-friendly than Twitter. I look forward to chatting about awesome science.
November 19, 2024 at 6:55 PM
I hope this place is more positive and science-friendly than Twitter. I look forward to chatting about awesome science.