Joseph Guhlin
josephguhlin.bsky.social
Joseph Guhlin
@josephguhlin.bsky.social
(he/him) Genomics Researcher. The Kākāpō Genomics Guy. Theoretical Genomicist. Annotation Artist. #Conservation #Bioinformatics #Rust #CompBio 🦀 #genomics #fedi22 #CompBio #popgen #Annotation #Stats #MachineLearning 🏳️‍🌈
#Conservation implications: treating hoiho as three subspecies changes the playbook. Mainland M. a. murihiku needs urgent, tailored action, and genetic rescue from subantarctic birds could risk outbreeding depression by introducing local adaptations younger than the species divergence.
October 28, 2025 at 8:08 PM
Re: RDS on the mainland. A GWAS within the Northern subspecies and all subspecies flags candidate genes tied to immunity and respiration.
October 28, 2025 at 8:08 PM
Using ARGs, we can trace population divergence across the genome. This “excess coalescence” plot shows when genomes begin to diverge. The timing aligns with the BEAST-inferred divergence windows, but using separate methodology.
(Not in the preprint, BTS!)
October 28, 2025 at 8:08 PM
When did they split? Molecular dating points to ~5–16k years for the Northern vs Southern split and ~3–11k years between the two Southern groups, dating to before human arrival in Aotearoa NZ. (Fig. 3)
October 28, 2025 at 8:08 PM
We sequenced ~249 whole genomes 🧬 spanning the mainland and subantarctic Enderby & Campbell Islands. Result: three distinct genetic lineages, with negligible gene flow among them (See PCA/tree in Fig. 2, and migration rates in supplement)!
October 28, 2025 at 8:08 PM
🐧We researched one of the world’s rarest #penguins. The yellow‑eyed penguin (aka hoiho/takaraka) isn’t one homogeneous species after all!

www.biorxiv.org/content/10.1...

#hoiho #conservation #genomics #birds #nzwildlife #endangered #wildlife #nature
October 28, 2025 at 8:08 PM
No cute-off, not a competition, haha..

Here's our 14-year-old with her bit of hearing loss
October 20, 2025 at 6:59 PM
Who chose this color scheme?
August 12, 2025 at 3:54 AM
Puppy cuddles and voyager....
June 19, 2025 at 8:59 AM
Guide: Switching from Conda/Mamba to Pixi. Near instant environments, better HPC compatibility and reproducibility. But really, it's the speed!

josephguhlin.com/pixi-uv-bioi...

#bioinformatics #genomics #python
January 8, 2025 at 10:49 PM
Fakeminimap2 now supports interactive visualization of results. Just for fun, but kinda useful. Watch until the end.

Built with Rust & @ratatui.rs

Try it out! Here, until GitHub allows PRs again:
github.com/jguhlin/mini...

#rust #rustlang #bioinformatics #genomics #ratatui
December 3, 2024 at 8:10 PM
Soon you'll be able to melt your phone, or run whole assemblies. #genomics #bioinformatics #rust #rustlang #longread
November 25, 2024 at 3:58 AM