Jonathan Repple
@jonathanrepple.bsky.social
Professor and Psychiatrist @Goethe University Frankfurt, Germany. Interested in Affective Disorders, Neuroscience, Networks, CBASP Psychotherapy, Neurostimulation, Depression Phenotyping
I probably missed a lot. What were your favorite ones?
January 26, 2025 at 6:59 PM
I probably missed a lot. What were your favorite ones?
And finally, @leaschumacher.bsky.social , Elisabeth Schramm, Levente Kriston and others showed in World Psychiatry that person-specific symptom networks strongly improved the accuracy of the prediction of psychotherapy response: onlinelibrary.wiley.com/doi/10.1002/...
Predicting the outcome of psychotherapy for chronic depression by person‐specific symptom networks
Psychotherapies are efficacious in the treatment of depression, albeit only with a moderate effect size. It is hoped that personalization of treatment can lead to better outcomes. The network theory ....
onlinelibrary.wiley.com
January 26, 2025 at 6:59 PM
And finally, @leaschumacher.bsky.social , Elisabeth Schramm, Levente Kriston and others showed in World Psychiatry that person-specific symptom networks strongly improved the accuracy of the prediction of psychotherapy response: onlinelibrary.wiley.com/doi/10.1002/...
Employing data from the ENIGMA consortium, Foivos Georgiadis, Matthias Kirschner and many others showed that the heterogeneous pattern of cortical alterations can be traced back to common brain circuits:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study - Molecular Psychiatry
Molecular Psychiatry - Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
www.nature.com
January 26, 2025 at 6:59 PM
Employing data from the ENIGMA consortium, Foivos Georgiadis, Matthias Kirschner and many others showed that the heterogeneous pattern of cortical alterations can be traced back to common brain circuits:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Back to brains, a study by @amiklos.bsky.social, Zhi-De Deng, Chris Abbott and many others from the GEMRIC consortium showed that changes in causal depression networks after electroconvulsive therapy relate to treatment outcome in MDD patients. This was published in Molecular Psychiatry:
Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression - Molecular Psychiatry
Molecular Psychiatry - Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
www.nature.com
January 26, 2025 at 6:59 PM
Back to brains, a study by @amiklos.bsky.social, Zhi-De Deng, Chris Abbott and many others from the GEMRIC consortium showed that changes in causal depression networks after electroconvulsive therapy relate to treatment outcome in MDD patients. This was published in Molecular Psychiatry:
For an overview of symptom network analysis, please read this great piece by @briganti.bsky.social, Denny Borboom, @eikofried.bsky.social, @tfblanken.bsky.social and Richard McNally and others published in the International Journal of Methods in Psychiatric Research:
Network analysis: An overview for mental health research
Network approaches to psychopathology have become increasingly common in mental health research, with many theoretical and methodological developments quickly gaining traction. This article illustrat...
onlinelibrary.wiley.com
January 26, 2025 at 6:59 PM
For an overview of symptom network analysis, please read this great piece by @briganti.bsky.social, Denny Borboom, @eikofried.bsky.social, @tfblanken.bsky.social and Richard McNally and others published in the International Journal of Methods in Psychiatric Research:
Back to symptom networks, Omar Ebrahimi, denny borsboom, Andrea Cipriani and colleagues demonstrated most MDD patients within the same depressive symptom severity group displayed differential symptom dynamics. This was published in the British Journal of Psychiatry: www.cambridge.org/core/journal...
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics as a clinical characterisation dimension in the assessment of major depressive disorder | The British Journal of ...
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics as a clinical characterisation dimension in the assessment of major depressive disorder - Volume 224 Issue 5
www.cambridge.org
January 26, 2025 at 6:59 PM
Back to symptom networks, Omar Ebrahimi, denny borsboom, Andrea Cipriani and colleagues demonstrated most MDD patients within the same depressive symptom severity group displayed differential symptom dynamics. This was published in the British Journal of Psychiatry: www.cambridge.org/core/journal...
In line, a new approach to study the extent of involved regions in functional brain networks based on repeated longitudinal measurements showed marked differences in salience network regions in MDD. This work by Charles Lynch, Conor Lyston and others was published in Nature Medicine:
Frontostriatal salience network expansion in individuals in depression - Nature
Precision functional mapping shows that the frontostriatal salience network occupies nearly twice as much of the cortex in people with depression, and this was unaffected by mood changes and detected ...
www.nature.com
January 26, 2025 at 6:59 PM
In line, a new approach to study the extent of involved regions in functional brain networks based on repeated longitudinal measurements showed marked differences in salience network regions in MDD. This work by Charles Lynch, Conor Lyston and others was published in Nature Medicine:
Next, a study on different brain subnetworks by @leotozzi.bsky.social, Leanne Williams and colleagues on brain subnetworks that relate to different symptom dimensions and treatment outcomes in major depressive disorder (MDD) published in Nature Medicine: www.nature.com/articles/s41...
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety - Nature Medicine
Personalized brain circuit measures quantified using a new imaging technology in 801 patients with depression and anxiety identify six biotypes with unique symptoms, behaviors and responses to differe...
www.nature.com
January 26, 2025 at 6:59 PM
Next, a study on different brain subnetworks by @leotozzi.bsky.social, Leanne Williams and colleagues on brain subnetworks that relate to different symptom dimensions and treatment outcomes in major depressive disorder (MDD) published in Nature Medicine: www.nature.com/articles/s41...
First, a two-part review on the theory and application of A Dynamical Systems View of Psychiatric Disorders written by Marten Scheffer, Barnaby Nelson, @clbockting.bsky.social, Denny Borsboom and others in JAMA Psychiatry:
A Dynamical Systems View of Psychiatric Disorders—Theory
This narrative review describes a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, which addresses the concepts of tipping points, cycles...
jamanetwork.com
January 26, 2025 at 6:59 PM
First, a two-part review on the theory and application of A Dynamical Systems View of Psychiatric Disorders written by Marten Scheffer, Barnaby Nelson, @clbockting.bsky.social, Denny Borsboom and others in JAMA Psychiatry:
which focuses on leveraging changes in dynamic network properties across these levels to improve our understanding and treatment of mental disorders. With that in mind, I wanted to share some of the most exciting papers I read in 2024 that explore brain or symptom networks in some capacity.
January 26, 2025 at 6:59 PM
which focuses on leveraging changes in dynamic network properties across these levels to improve our understanding and treatment of mental disorders. With that in mind, I wanted to share some of the most exciting papers I read in 2024 that explore brain or symptom networks in some capacity.