John W. Sanford (Glycan Appreciator)
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johnsanford113.bsky.social
John W. Sanford (Glycan Appreciator)
@johnsanford113.bsky.social
PhD candidate in microbiology at UAB studying strange glycosylation on the surface of minimal genome bacteria.
Known to talk about mycoplasmas to anyone who will listen.
Incredibly lame that right-wing billionaires are:
1. Lame enough to be obsessed with what’s happening in their Alma maters like high school football dudes
2. Powerful enough to get the government to collectively punish the least ideological people on campus (biomedical researchers)
March 12, 2025 at 12:50 AM
Reposted by John W. Sanford (Glycan Appreciator)
As a Jew I will feel a lot safer at Columbia knowing that there are fewer graduate students toiling in labs to cure cancer and drug addiction.
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia.

This is quite damaging to research and to individuals.

This is pure terrorism and cannot be legal. But litigation will take time...
March 11, 2025 at 4:41 PM
Reposted by John W. Sanford (Glycan Appreciator)
Here it is – THE largest global dataset for Mycoplasma pneumoniae, describing the global spatiotemporal dynamics of its historical re-emergence after COVID-19 pandemic restrictions.

www.thelancet.com/journals/lan...
Global spatiotemporal dynamics of Mycoplasma pneumoniae re-emergence after COVID-19 pandemic restrictions: an epidemiological and transmission modelling study
This large global dataset for M pneumoniae detections shows that although there was an unprecedented high number of detections across many countries in late 2023, the severity and number of deaths rem...
www.thelancet.com
February 27, 2025 at 9:44 PM
Reposted by John W. Sanford (Glycan Appreciator)
I just received the first strongly worded email from my leaders indicating they would fight this most recent change to IDCs. All I hear was that it wasn’t worth fighting for when it was about trainees, early career scientists, and POC. Heard loud and clear.
February 8, 2025 at 2:44 PM
The quest for a minimal bacterium appears to be a race between reducing E. coli and designing a mycoplasma.
It’ll be interesting to see how much further we could reduce endosymbionts — and the potential applications of custom endosymbionts!
Inducing novel endosymbioses by implanting bacteria in fungi - Nature
A study presents an approach to establish and track a new endosymbiotic partnership by implanting bacteria in a non-host fungus and shows that stable inheritance of the implanted bacteria is possible ...
www.nature.com
January 28, 2025 at 3:49 AM
Fourier transforms finally make sense to me 🎉
www.youtube.com/watch?v=r18G...
Fourier Transform, Fourier Series, and frequency spectrum
YouTube video by Physics Videos by Eugene Khutoryansky
www.youtube.com
December 24, 2024 at 6:48 PM
Christmas came early to lab! A whole set of JCVI-syn1.0 strains with different non-essential gene sets removed before the syn3.0 minimal cell. Many thanks to John Glass and the JCVI for sending these! Excited to see what secrets lie in store…
December 18, 2024 at 8:26 PM
Turns out a mycoplasma can live on just two (2) lipids. Although they certainly don’t seem too happy about the whole affair…
www.nature.com/articles/s41...
A tuneable minimal cell membrane reveals that two lipid species suffice for life - Nature Communications
All cells are encapsulated by a membrane of complex lipidic composition, and understanding the roles of different lipids in membrane function is experimentally challenging to address. Here, Justice et...
www.nature.com
November 16, 2024 at 5:20 PM