Jogender Singh
@jogender-singh.bsky.social
Assistant Professor at IISER Mohali
Pinned
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways | The EMBO Journal
imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis elegans, extend the host’s lifespan by ...
www.embopress.org
I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org!
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org!
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways | The EMBO Journal
imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis elegans, extend the host’s lifespan by ...
www.embopress.org
November 10, 2025 at 2:15 PM
I’m thrilled to share that our latest work, led by PhD scholar Priyanka Das, is published in @embojournal.org!
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Using a bacterial mutant library screen, we identified that bacterial-induced ROS extends C. elegans lifespan by disrupting its iron homeostasis. www.embopress.org/doi/full/10....
Reposted by Jogender Singh
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
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wormglia.org
June 16, 2025 at 9:16 PM
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc @glia-maria.bsky.social, team, & collaboration with @manusetty.bsky.social . Find insights into glia, new analytics and ML models, and browse our companion website (wormglia.org)
Reposted by Jogender Singh
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.06.09.658597v1
June 12, 2025 at 12:03 AM
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.06.09.658597v1
Reposted by Jogender Singh
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.06.09.658597v1
June 12, 2025 at 12:03 AM
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.06.09.658597v1
Pleased to share our latest work by Shivani and Subodh. We show that the essential amino acid Trp is highly toxic to C. elegans. It turns out that the bacterial diet is the culprit. Bacterial metabolism of Trp to indole causes the toxicity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans
Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nico...
www.biorxiv.org
June 12, 2025 at 2:55 AM
Pleased to share our latest work by Shivani and Subodh. We show that the essential amino acid Trp is highly toxic to C. elegans. It turns out that the bacterial diet is the culprit. Bacterial metabolism of Trp to indole causes the toxicity.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jogender Singh
Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling - Nature Communications
The authors show that in C. elegans, Vitamin B12-driven changes in neuronal methionine cycle trigger a neuron-gut signalling axis, involving serotonin and neuropeptide secretion that modulate stress t...
www.nature.com
June 3, 2025 at 2:35 AM
Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jogender Singh
Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
Postdoctoral Research Associate, Biology
About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...
northeastern.wd1.myworkdayjobs.com
April 29, 2025 at 8:54 PM
Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
Reposted by Jogender Singh
Worm people: We need YOU to help recruit more mentees for the C. elegans Community Mentor Match program! 🪱✨
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
Join the C. elegans Community Mentor Match Program!
Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/DpGTWRMrNGL96wHy8 https://forms.gle/pVBD5DYGXyLT4waLA
docs.google.com
March 17, 2025 at 5:36 PM
Worm people: We need YOU to help recruit more mentees for the C. elegans Community Mentor Match program! 🪱✨
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
Reposted by Jogender Singh
Worm friends: The C. elegans Community Mentor Match Program is signing up mentees!
Click on the link to be matched with a mentor and/or to join a peer-mentoring group.
Please spread the word, and share with your lab members and worm friends! 📢
1/n
Click on the link to be matched with a mentor and/or to join a peer-mentoring group.
Please spread the word, and share with your lab members and worm friends! 📢
1/n
Mentee sign-up for the 2025 C. elegans Community Mentor Match program
The 2025 C. elegans Community Mentor Match is open to graduate students, postdocs, and faculty at any career stage. This survey collects information to help the committee (a) identify the most appropr...
forms.gle
March 12, 2025 at 8:31 PM
Worm friends: The C. elegans Community Mentor Match Program is signing up mentees!
Click on the link to be matched with a mentor and/or to join a peer-mentoring group.
Please spread the word, and share with your lab members and worm friends! 📢
1/n
Click on the link to be matched with a mentor and/or to join a peer-mentoring group.
Please spread the word, and share with your lab members and worm friends! 📢
1/n
Reposted by Jogender Singh
The first one is some crazy work by @monmitabhar.bsky.social, Tanumoy, @hari-flies.bsky.social and Kamal Kishore. They eavesdropped on worm conversations and found the exciting phenomenon of movement of memory from one worm to another 2/n www.biorxiv.org/content/10.1...
Extracellular vesicles aid in the transfer of long-term associative memory between Caenorhabditis elegans
Memory formation is necessary for the survival of animals across phyla. Here, we elucidate the mechanism underlying the formation of long-term associative memory (LTAM) formed by treating Caenorhabdit...
www.biorxiv.org
February 27, 2025 at 12:28 PM
The first one is some crazy work by @monmitabhar.bsky.social, Tanumoy, @hari-flies.bsky.social and Kamal Kishore. They eavesdropped on worm conversations and found the exciting phenomenon of movement of memory from one worm to another 2/n www.biorxiv.org/content/10.1...
Reposted by Jogender Singh
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways https://www.biorxiv.org/content/10.1101/2025.02.11.637611v1
February 16, 2025 at 6:04 AM
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways https://www.biorxiv.org/content/10.1101/2025.02.11.637611v1
Reposted by Jogender Singh
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways https://www.biorxiv.org/content/10.1101/2025.02.11.637611v1
February 16, 2025 at 6:04 AM
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways https://www.biorxiv.org/content/10.1101/2025.02.11.637611v1
Happy to share our latest work led by grad student Priyanka Das. Using a genome-wide bacterial screen, we identify that dietary iron limitation extends C. elegans lifespan via its oxidative stress response pathways.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways
Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression...
www.biorxiv.org
February 17, 2025 at 3:31 AM
Happy to share our latest work led by grad student Priyanka Das. Using a genome-wide bacterial screen, we identify that dietary iron limitation extends C. elegans lifespan via its oxidative stress response pathways.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Happy to share a review by grad student Ravi on the complex crosstalk between redox homeostasis and hypoxia signaling in the FEBS Journal. We also discuss the future research prospects at this exciting interface.
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Redox homeostasis, the balance between oxidative and reductive processes, is essential for cellular function and organismal health. Disruption, either through excessive oxidants (oxidative stress) or...
febs.onlinelibrary.wiley.com
February 11, 2025 at 12:39 PM
Happy to share a review by grad student Ravi on the complex crosstalk between redox homeostasis and hypoxia signaling in the FEBS Journal. We also discuss the future research prospects at this exciting interface.
febs.onlinelibrary.wiley.com/doi/full/10....
febs.onlinelibrary.wiley.com/doi/full/10....