Jessica Sacher
@jessicasacher.bsky.social
phage therapy scientist at Stanford, building community at Phage Directory, writing about adventures from the lab to the clinic -> https://jess.bio
🧬 Big Pharma's antibiotic problem:
A successful drug + FDA approval = $776M loss
Here's how that happens 🧵
A successful drug + FDA approval = $776M loss
Here's how that happens 🧵
December 11, 2024 at 5:58 PM
🧬 Big Pharma's antibiotic problem:
A successful drug + FDA approval = $776M loss
Here's how that happens 🧵
A successful drug + FDA approval = $776M loss
Here's how that happens 🧵
This is so good!
A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...
www.danielnettle.org.uk
December 9, 2024 at 5:55 PM
This is so good!
Laughed out loud — phage field, there’s still hope for us 😂
Source: Kate Zernike’s The Exceptions — highly recommend, cannot put it down!!
Source: Kate Zernike’s The Exceptions — highly recommend, cannot put it down!!
December 4, 2024 at 5:10 AM
Laughed out loud — phage field, there’s still hope for us 😂
Source: Kate Zernike’s The Exceptions — highly recommend, cannot put it down!!
Source: Kate Zernike’s The Exceptions — highly recommend, cannot put it down!!
Reposted by Jessica Sacher
Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio
November 19, 2024 at 3:07 PM
Hello 🦋 #protein / #microbio / #BioML community! We are excited to release Gaia🌎, a context-aware protein search tool, extending protein search and discovery capabilities beyond sequence and structure, to include *genomic context*. Search your favorite protein sequences with on gaia.tatta.bio
Reposted by Jessica Sacher
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
November 19, 2024 at 8:03 PM
Do you feel stressed?
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Is it one thing or a combination?
Turns out bacteria can’t handle stress either!
Excited to share my first first author paper out now in @currentbiology.bsky.social!
Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
Reposted by Jessica Sacher
A review on "Bacterial Organelles in Iron Physiology" from Hualiang Pi et al.
Joe Neilands (a siderophore pioneer) once stated that Fe was too important for bacteria to export. Bacteria DO export Fe, but they can also store it in organelles.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Joe Neilands (a siderophore pioneer) once stated that Fe was too important for bacteria to export. Bacteria DO export Fe, but they can also store it in organelles.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Bacterial Organelles in Iron Physiology
A proposed model of iron trafficking during ferrosome formation.
onlinelibrary.wiley.com
November 18, 2024 at 12:13 AM
A review on "Bacterial Organelles in Iron Physiology" from Hualiang Pi et al.
Joe Neilands (a siderophore pioneer) once stated that Fe was too important for bacteria to export. Bacteria DO export Fe, but they can also store it in organelles.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Joe Neilands (a siderophore pioneer) once stated that Fe was too important for bacteria to export. Bacteria DO export Fe, but they can also store it in organelles.
#MicroSky
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Jessica Sacher
Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n
Xue lab at UC Irvine
Ecology and evolution in the human gut microbiome
kxuelab.com
November 19, 2024 at 6:57 PM
Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n
Reposted by Jessica Sacher
Trying to purify and sequence #phage for phage therapy?
Try #sphae a new approach to identify if your phage could be useful for treatment
#phagesky
Try #sphae a new approach to identify if your phage could be useful for treatment
#phagesky
Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1
Sphae: An automated toolkit for predicting phage therapy candidates from sequencing data https://www.biorxiv.org/content/10.1101/2024.11.18.624194v1
Motivation: Phage therapy is a viable alternative for treating bacterial infections amidst the escal
www.biorxiv.org
November 19, 2024 at 3:09 AM
Reposted by Jessica Sacher
Honoured to have been voted as President-elect of the International Society for the Viruses of Microbes (ISVM) and excited to work with the Executive Board over the next few years
#phagesky
phagesociety.org
#phagesky
phagesociety.org
ISVM – International Society for Viruses of Microorganisms
phagesociety.org
November 19, 2024 at 3:12 AM
Honoured to have been voted as President-elect of the International Society for the Viruses of Microbes (ISVM) and excited to work with the Executive Board over the next few years
#phagesky
phagesociety.org
#phagesky
phagesociety.org
Reposted by Jessica Sacher
When applying to NSF for funding, each senior personnel has to provide a “Collaborators and Other Affiliations” (COA) form, which can be quite onerous. A couple of years ago I created a tool bit.ly/NSF_COA for automating this, and recently hardened it. I hope it is of use, and feedback is welcome! 🧪
NSF COA generator
bit.ly
November 17, 2024 at 7:22 AM
When applying to NSF for funding, each senior personnel has to provide a “Collaborators and Other Affiliations” (COA) form, which can be quite onerous. A couple of years ago I created a tool bit.ly/NSF_COA for automating this, and recently hardened it. I hope it is of use, and feedback is welcome! 🧪
Reposted by Jessica Sacher
Welcome! I created the account a while ago but paying attention since yesterday. I have found three phage phlocks so far:
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
November 13, 2024 at 6:48 PM
Welcome! I created the account a while ago but paying attention since yesterday. I have found three phage phlocks so far:
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
1. #phagesky list
2. Starter pack bsky.app/starter-pack...
3. Starter pack bsky.app/starter-pack...
Reposted by Jessica Sacher
Geometriphylogenetics xkcd.com/3010
November 13, 2024 at 1:03 PM
Geometriphylogenetics xkcd.com/3010
Phage friends, I’ve been told you’re all here?! Yay! What lists should I join? Complete newb 😳
November 13, 2024 at 6:36 PM
Phage friends, I’ve been told you’re all here?! Yay! What lists should I join? Complete newb 😳
Food!! Hello Melbourne you’re delicious!
April 29, 2023 at 1:11 AM
Food!! Hello Melbourne you’re delicious!