Seems heads are already rolling.

In fig 5 of the 🔗 paper, I compared the durability of protective immunity elicited by same doses of the exact same virus/vaccine (non replicating). One was inactivated with formalin (open circles); the other was not (closed circles). Inactivation killed durability. www.nature.com/articles/nm....

I noticed this statement from NIH regarding durability of the inactivated approach. I didn’t see any durability data in the published studies of this candidate. Anyone aware of durability studies performed using inactivated virus platforms? I did one experiment in grad school (in thread below).

Don’t get me wrong, I’m appalled by what this administration is doing to science. But I think there is something else going on here. Whatever happened will undoubtedly get politicized though.

Beautiful day to stand up for science!

Vashon island struggling to roll out of bed this morning.

Visiting the Department of Microbiology and Immunology at Einstein on a clear, freezing cold day today. Looking forward to the discussions!

New paper from Amit Khandhar’s team at HDT Bio demonstrating that our LION/repRNA platform can be thermostabilized by lyophilization, enabling refrigerator stability for at least 1 year!

Clear implications for global access to vaccines based on our technology.

authors.elsevier.com/c/1k6n4cI2-5...

Weaver lab reunion at #ASTMH in NOLA. #ViroSky

Regarding the potential req. for getting vaccine antigen to mucosal surfaces to induce protective mucosal immunity, I just want to post this figure from one of our recent pubs. We show, following IM RNA vaccination, differential protection of the upper airway that was dependent on formulation (C).

Just logged back in and see things are quite lively here! Here’s a picture of some #bluesky from the recent plus strand virus meeting in Ireland. I’ll try to post more updates from my team as we continue to advance repRNA vaccines against emerging infectious diseases. #virology #RNAsky

A lot of good science happening in India and a great venue for the annual Indo-US vaccine action program meeting.

Had a great time last week reconnecting with old friends at UTMB and speaking at the GSBS research expo. An excellent environment for infectious disease research. Just gotta love humidity and the occasional flying cockroach.