Jeff Vierstra
@jeffvierstra.bsky.social
Senior Investigator @ Altius Institute for Biomedical Sciences. Research: High-resolution mapping of chromatin structure & function. Fun: Mountain shenanigans and skiing turns all year. Seattle, USA/Patagonia Chilena (🇺🇸🇨🇱). http://vierstra.org
We also showed in a 2015 manuscript that the RREB1 site CCCCCACCC, also has a modest effect on HbF reactivation.
August 13, 2025 at 9:44 PM
We also showed in a 2015 manuscript that the RREB1 site CCCCCACCC, also has a modest effect on HbF reactivation.
Also, all the credit goes to @sboytsov.bsky.social and @sabromav.bsky.social.
July 9, 2025 at 2:48 PM
Also, all the credit goes to @sboytsov.bsky.social and @sabromav.bsky.social.
We have applied this to ~4000 DNase I and >10,000 ATAC-seq (publicly available on SRA) datasets, and it seems to pass the "taste-test" as we call it. Maybe sometime in the future we will write this up -- though don't hold your breath 😂.
July 8, 2025 at 6:12 PM
We have applied this to ~4000 DNase I and >10,000 ATAC-seq (publicly available on SRA) datasets, and it seems to pass the "taste-test" as we call it. Maybe sometime in the future we will write this up -- though don't hold your breath 😂.
Here is slide demonstrating how it works w.r.t. to the highly aneuploid, yet very commonly used cell-line K562.
July 8, 2025 at 6:07 PM
Here is slide demonstrating how it works w.r.t. to the highly aneuploid, yet very commonly used cell-line K562.
July 8, 2025 at 6:06 PM
Here is slide demonstrating how it works w.r.t. to the highly aneuploid, yet very commonly used cell-line K562.
Of course. We first segment the genome by background (a proxy for copy number variation) and then call peaks.
July 8, 2025 at 1:49 PM
Of course. We first segment the genome by background (a proxy for copy number variation) and then call peaks.