Check out HMFF and Mosaic on GitHub: (7/n)
🔗 github.com/KosinskiLab/...

HMFF comes with Mosaic, a software ecosystem for membrane segmentation, refinement, HMFF simulations, and morphometrics. (6/n) 🔗https://github.com/KosinskiLab/mosaic

For example, it allows building models like this filamentous influenza A virion ⬇️ (5/n)

HMFF aids in on-membrane particle picking, supports multiscale modeling, and allows backmapping to atomic detail (4/n)

This enables physically realistic and complete membrane models of cells, organelles, and viruses, consistent with experimental data (3/n)

Helfrich Monte Carlo Flexible Fitting (HMFF) optimizes membrane models directly in electron microscopy densities (2/n)

Great work led by our PhD student Iuliia Kotova in collaboration with Fan Liu @fan-liu.bsky.social, Boris Bogdanow, Lars Mühlberg, and Olivier Duss @olivierduss.bsky.social and Guelsah Gabriel labs. Structural analysis by our PhD student Konstantin Gilep.
www.biorxiv.org/content/10.1...

yeah, it went bananas