James Zou
@jameszou.bsky.social
@Stanford Professor. AI for science and medicine.
Pinned
James Zou
@jameszou.bsky.social
· Jul 29
⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41...
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
Reposted by James Zou
New paper out in @natmethods.nature.com from @elhamazizi.bsky.social, Kam Leong & @jameszou.bsky.social! The team developed Squidiff, a diffusion #AI model to predict cellular responses to environmental cues and accelerate #PrecisionMedicine.
Learn more: bit.ly/3WRPNsx
Learn more: bit.ly/3WRPNsx
November 10, 2025 at 1:59 PM
New paper out in @natmethods.nature.com from @elhamazizi.bsky.social, Kam Leong & @jameszou.bsky.social! The team developed Squidiff, a diffusion #AI model to predict cellular responses to environmental cues and accelerate #PrecisionMedicine.
Learn more: bit.ly/3WRPNsx
Learn more: bit.ly/3WRPNsx
Reposted by James Zou
Large language models (LLMs) may not reliably acknowledge a user’s incorrect beliefs, according to a paper in Nature Machine Intelligence. The findings highlight the need for careful use of LLM outputs in high-stakes decisions. go.nature.com/48VRpIQ 🧪
November 3, 2025 at 8:14 PM
Large language models (LLMs) may not reliably acknowledge a user’s incorrect beliefs, according to a paper in Nature Machine Intelligence. The findings highlight the need for careful use of LLM outputs in high-stakes decisions. go.nature.com/48VRpIQ 🧪
It’s here! #Agents4Science recording is now on YouTube!
🏆 3 Best Paper talks
⚡️ 11 Spotlights
🧠 Panel on the future of AI agent-driven science
📚 Lessons + surprises from this first-of-its kind conf
Full analysis of submissions + reviews coming soon! youtube.com/watch?v=7pXq...
🏆 3 Best Paper talks
⚡️ 11 Spotlights
🧠 Panel on the future of AI agent-driven science
📚 Lessons + surprises from this first-of-its kind conf
Full analysis of submissions + reviews coming soon! youtube.com/watch?v=7pXq...
October 23, 2025 at 3:13 PM
It’s here! #Agents4Science recording is now on YouTube!
🏆 3 Best Paper talks
⚡️ 11 Spotlights
🧠 Panel on the future of AI agent-driven science
📚 Lessons + surprises from this first-of-its kind conf
Full analysis of submissions + reviews coming soon! youtube.com/watch?v=7pXq...
🏆 3 Best Paper talks
⚡️ 11 Spotlights
🧠 Panel on the future of AI agent-driven science
📚 Lessons + surprises from this first-of-its kind conf
Full analysis of submissions + reviews coming soon! youtube.com/watch?v=7pXq...
Reposted by James Zou
Next week @jameszou.bsky.social & colleagues will host a conference where all the papers are written by AI agents & reviewed by them too.
What do you reckon? A good chance to put AIs through their paces? Or a way to divert AI slop from elsewhere? 🧪🤖
My story here:
www.nature.com/articles/d41...
What do you reckon? A good chance to put AIs through their paces? Or a way to divert AI slop from elsewhere? 🧪🤖
My story here:
www.nature.com/articles/d41...
AI bots wrote and reviewed all papers at this conference
Event will assess how reviews by models compare with those written by humans.
www.nature.com
October 15, 2025 at 11:00 AM
Next week @jameszou.bsky.social & colleagues will host a conference where all the papers are written by AI agents & reviewed by them too.
What do you reckon? A good chance to put AIs through their paces? Or a way to divert AI slop from elsewhere? 🧪🤖
My story here:
www.nature.com/articles/d41...
What do you reckon? A good chance to put AIs through their paces? Or a way to divert AI slop from elsewhere? 🧪🤖
My story here:
www.nature.com/articles/d41...
Reposted by James Zou
As of June 2025, 66% of Americans have never used ChatGPT.
Our new position paper, Attention to Non-Adopters, explores why this matters: AI research is being shaped around adopters—leaving non-adopters’ needs, and key LLM research opportunities, behind.
arxiv.org/abs/2510.15951
Our new position paper, Attention to Non-Adopters, explores why this matters: AI research is being shaped around adopters—leaving non-adopters’ needs, and key LLM research opportunities, behind.
arxiv.org/abs/2510.15951
October 21, 2025 at 5:12 PM
As of June 2025, 66% of Americans have never used ChatGPT.
Our new position paper, Attention to Non-Adopters, explores why this matters: AI research is being shaped around adopters—leaving non-adopters’ needs, and key LLM research opportunities, behind.
arxiv.org/abs/2510.15951
Our new position paper, Attention to Non-Adopters, explores why this matters: AI research is being shaped around adopters—leaving non-adopters’ needs, and key LLM research opportunities, behind.
arxiv.org/abs/2510.15951
Reposted by James Zou
"We found a troubling emergent behavior in LLM.
—When LLMs compete for social media likes, they start making things up.
—When they compete for votes, they turn inflammatory/populist.
—When optimized for audiences, LLMs inadvertently become misaligned."
→ Moloch's Bargain @jameszou.bsky.social #AI
—When LLMs compete for social media likes, they start making things up.
—When they compete for votes, they turn inflammatory/populist.
—When optimized for audiences, LLMs inadvertently become misaligned."
→ Moloch's Bargain @jameszou.bsky.social #AI
October 9, 2025 at 4:41 PM
"We found a troubling emergent behavior in LLM.
—When LLMs compete for social media likes, they start making things up.
—When they compete for votes, they turn inflammatory/populist.
—When optimized for audiences, LLMs inadvertently become misaligned."
→ Moloch's Bargain @jameszou.bsky.social #AI
—When LLMs compete for social media likes, they start making things up.
—When they compete for votes, they turn inflammatory/populist.
—When optimized for audiences, LLMs inadvertently become misaligned."
→ Moloch's Bargain @jameszou.bsky.social #AI
Reposted by James Zou
#AI wrote nearly a quarter of corporate press releases in 2024 and the number is likely to keep rising. spkl.io/63324ATfBo
Weixin Liang, @jameszou.bsky.social & colleagues
@cp-patterns.bsky.social
Weixin Liang, @jameszou.bsky.social & colleagues
@cp-patterns.bsky.social
October 2, 2025 at 3:00 PM
#AI wrote nearly a quarter of corporate press releases in 2024 and the number is likely to keep rising. spkl.io/63324ATfBo
Weixin Liang, @jameszou.bsky.social & colleagues
@cp-patterns.bsky.social
Weixin Liang, @jameszou.bsky.social & colleagues
@cp-patterns.bsky.social
Reposted by James Zou
@stanforddeptmed.bsky.social Biomedical Informatics Research Colloquia
“AI Agents to Automate Biomedical Discoveries”
@jameszou.bsky.social James Zou, Ph.D
Thursday, September 25th, 2025
12:00 to 1:00 pm PST
stanford.zoom.us/j/9788759601...
Webinar ID: 978 8759 6012
Webinar Passcode: 420642
“AI Agents to Automate Biomedical Discoveries”
@jameszou.bsky.social James Zou, Ph.D
Thursday, September 25th, 2025
12:00 to 1:00 pm PST
stanford.zoom.us/j/9788759601...
Webinar ID: 978 8759 6012
Webinar Passcode: 420642
September 23, 2025 at 1:05 PM
@stanforddeptmed.bsky.social Biomedical Informatics Research Colloquia
“AI Agents to Automate Biomedical Discoveries”
@jameszou.bsky.social James Zou, Ph.D
Thursday, September 25th, 2025
12:00 to 1:00 pm PST
stanford.zoom.us/j/9788759601...
Webinar ID: 978 8759 6012
Webinar Passcode: 420642
“AI Agents to Automate Biomedical Discoveries”
@jameszou.bsky.social James Zou, Ph.D
Thursday, September 25th, 2025
12:00 to 1:00 pm PST
stanford.zoom.us/j/9788759601...
Webinar ID: 978 8759 6012
Webinar Passcode: 420642
Reposted by James Zou
Fantastic talk by @stanford.edu's @jameszou.bsky.social for the first Innovation Initiative Distinguished Lecture at @whiteheadinstitute.bsky.social. A fascinating look at how to use #AI to build intelligent research teams that can tackle open-ended scientific problems. #WhiteheadInstitute #MIT
September 11, 2025 at 8:38 PM
Fantastic talk by @stanford.edu's @jameszou.bsky.social for the first Innovation Initiative Distinguished Lecture at @whiteheadinstitute.bsky.social. A fascinating look at how to use #AI to build intelligent research teams that can tackle open-ended scientific problems. #WhiteheadInstitute #MIT
🧠Can AI agents predict #Alzheimers? Participate in our DREAM challenge agentic track to find out!
We provide unique training + test data for AI agents: snRNA-seq, IHC, stage, etc synapse.org/Synapse:syn6...
Also co-submit your agent paper to agents4science.stanford.edu
We provide unique training + test data for AI agents: snRNA-seq, IHC, stage, etc synapse.org/Synapse:syn6...
Also co-submit your agent paper to agents4science.stanford.edu
August 12, 2025 at 10:59 PM
🧠Can AI agents predict #Alzheimers? Participate in our DREAM challenge agentic track to find out!
We provide unique training + test data for AI agents: snRNA-seq, IHC, stage, etc synapse.org/Synapse:syn6...
Also co-submit your agent paper to agents4science.stanford.edu
We provide unique training + test data for AI agents: snRNA-seq, IHC, stage, etc synapse.org/Synapse:syn6...
Also co-submit your agent paper to agents4science.stanford.edu
Reposted by James Zou
“Good science happens when we have deep, interdisciplinary collaborations, and often that’s one of the main bottlenecks and challenging parts of research,” said HAI Faculty Affiliate @jameszou.bsky.social who led a study on AI-driven virtual labs: med.stanford.edu/news/all-new...
Researchers create ‘virtual scientists’ to solve complex biological problems
Stanford Medicine researchers created a team of virtual scientists backed by artificial intelligence to help solve problems in their real-world lab.
med.stanford.edu
August 11, 2025 at 3:34 PM
“Good science happens when we have deep, interdisciplinary collaborations, and often that’s one of the main bottlenecks and challenging parts of research,” said HAI Faculty Affiliate @jameszou.bsky.social who led a study on AI-driven virtual labs: med.stanford.edu/news/all-new...
Nice @stanforduniversity.bsky.social article profiling our #VirtualLab of AI scientists news.stanford.edu/stories/2025...
Researchers create ‘virtual scientists’ to solve complex biological problems
An AI lab developed by Stanford Medicine researchers has already shown promising results, generating ideas for a more effective COVID-19 vaccine in just a few days.
news.stanford.edu
July 31, 2025 at 3:16 PM
Nice @stanforduniversity.bsky.social article profiling our #VirtualLab of AI scientists news.stanford.edu/stories/2025...
Reposted by James Zou
Case Study by Eric Wu, PhD, Kevin Wu, PhD, and James Zou, PhD: Limitations of Learning New and Updated Medical Knowledge with Commercial Fine-Tuning Large Language Models nejm.ai/4nTx1Np
@jameszou.bsky.social #AI #MedSky
@jameszou.bsky.social #AI #MedSky
July 30, 2025 at 1:15 PM
Case Study by Eric Wu, PhD, Kevin Wu, PhD, and James Zou, PhD: Limitations of Learning New and Updated Medical Knowledge with Commercial Fine-Tuning Large Language Models nejm.ai/4nTx1Np
@jameszou.bsky.social #AI #MedSky
@jameszou.bsky.social #AI #MedSky
⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41...
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
July 29, 2025 at 4:05 PM
⚡️Thrilled that #VirtualLab is published in @nature.com! www.nature.com/articles/s41...
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
We created a team of AI agents to mirror my Stanford lab 🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.
Reposted by James Zou
Who do you call when you need to design novel, potent nanobodies vs a pathogen?
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
July 29, 2025 at 3:47 PM
Who do you call when you need to design novel, potent nanobodies vs a pathogen?
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
Reposted by James Zou
Day 3 of #ISMBECCB2025 started with an excellent talk from @jameszou.bsky.social which presented how AI can form virtual labs to discuss problems, how can AI reanalyse research data to get new biological results, and how we can interpret complex AI predictions 💻🤖
July 22, 2025 at 8:54 AM
Day 3 of #ISMBECCB2025 started with an excellent talk from @jameszou.bsky.social which presented how AI can form virtual labs to discuss problems, how can AI reanalyse research data to get new biological results, and how we can interpret complex AI predictions 💻🤖
Reposted by James Zou
Six frontier large language models evaluated on incorporating newly updated medical knowledge through commercial fine-tuning application programming interfaces struggled to generalize updated information, despite modest gains. Learn more: nejm.ai/4nTx1Np
@jameszou.bsky.social
@jameszou.bsky.social
July 23, 2025 at 1:15 PM
Six frontier large language models evaluated on incorporating newly updated medical knowledge through commercial fine-tuning application programming interfaces struggled to generalize updated information, despite modest gains. Learn more: nejm.ai/4nTx1Np
@jameszou.bsky.social
@jameszou.bsky.social
🏆Thrilled that #CollabLLM won the #ICML2025 Outstanding Paper Award!
We propose a new approach to optimize human-AI collaboration, which is critical for agents. Congratulations to my fantastic co-authors; great job Shirley Wu and Michel Galley driving the project! 👏
Paper: arxiv.org/pdf/2502.00640
We propose a new approach to optimize human-AI collaboration, which is critical for agents. Congratulations to my fantastic co-authors; great job Shirley Wu and Michel Galley driving the project! 👏
Paper: arxiv.org/pdf/2502.00640
July 15, 2025 at 5:55 PM
🏆Thrilled that #CollabLLM won the #ICML2025 Outstanding Paper Award!
We propose a new approach to optimize human-AI collaboration, which is critical for agents. Congratulations to my fantastic co-authors; great job Shirley Wu and Michel Galley driving the project! 👏
Paper: arxiv.org/pdf/2502.00640
We propose a new approach to optimize human-AI collaboration, which is critical for agents. Congratulations to my fantastic co-authors; great job Shirley Wu and Michel Galley driving the project! 👏
Paper: arxiv.org/pdf/2502.00640
What is it like for scientists to work with AI co-scientists?
Excellent @nature.com feature discussing researchers' experience interacting with our #VirtualLab and other tools www.nature.com/articles/d41...
Excellent @nature.com feature discussing researchers' experience interacting with our #VirtualLab and other tools www.nature.com/articles/d41...
AI ‘scientists’ joined these research teams: here’s what happened
Emerging ‘co-scientist’ systems use chatbots to mimic the deliberations of a research group. Nature asked researchers to test them out.
www.nature.com
July 7, 2025 at 4:34 PM
What is it like for scientists to work with AI co-scientists?
Excellent @nature.com feature discussing researchers' experience interacting with our #VirtualLab and other tools www.nature.com/articles/d41...
Excellent @nature.com feature discussing researchers' experience interacting with our #VirtualLab and other tools www.nature.com/articles/d41...
Reposted by James Zou
Introducing EvoLM, a model suite with 100+ decoder-only LMs (1B/4B) trained from scratch, across four training stages —
🟦 Pre-training
🟩 Continued Pre-Training (CPT)
🟨 Supervised Fine-Tuning (SFT)
🟥 Reinforcement Learning (RL)
🟦 Pre-training
🟩 Continued Pre-Training (CPT)
🟨 Supervised Fine-Tuning (SFT)
🟥 Reinforcement Learning (RL)
EvoLM: In Search of Lost Language Model Training Dynamics
Modern language model (LM) training has been divided into multiple stages, making it difficult for downstream developers to evaluate the impact of design choices made at each stage. We present EvoLM, ...
arxiv.org
July 2, 2025 at 8:05 PM
Introducing EvoLM, a model suite with 100+ decoder-only LMs (1B/4B) trained from scratch, across four training stages —
🟦 Pre-training
🟩 Continued Pre-Training (CPT)
🟨 Supervised Fine-Tuning (SFT)
🟥 Reinforcement Learning (RL)
🟦 Pre-training
🟩 Continued Pre-Training (CPT)
🟨 Supervised Fine-Tuning (SFT)
🟥 Reinforcement Learning (RL)
💡IMO one of the best use of AI Scientist is to reanalyze data to find new insights.
Introducing #CellVoyager: AI Compbio Agent that makes new discoveries by autonomously analyzing papers/data, which we then validate🚀
New findings on aging, Covid, scRNAseq etc. Open source!
Introducing #CellVoyager: AI Compbio Agent that makes new discoveries by autonomously analyzing papers/data, which we then validate🚀
New findings on aging, Covid, scRNAseq etc. Open source!
June 5, 2025 at 2:25 PM
💡IMO one of the best use of AI Scientist is to reanalyze data to find new insights.
Introducing #CellVoyager: AI Compbio Agent that makes new discoveries by autonomously analyzing papers/data, which we then validate🚀
New findings on aging, Covid, scRNAseq etc. Open source!
Introducing #CellVoyager: AI Compbio Agent that makes new discoveries by autonomously analyzing papers/data, which we then validate🚀
New findings on aging, Covid, scRNAseq etc. Open source!
Reposted by James Zou
Very cool work from James Zou. Link to paper: www.nature.com/articles/s41...
May 28, 2025 at 11:44 AM
Very cool work from James Zou. Link to paper: www.nature.com/articles/s41...
Excited that nuclei.io is featured on the cover of Nature BME! AI-clinician collaboration paper rdcu.be/dLgV1
April 22, 2025 at 4:35 PM
Excited that nuclei.io is featured on the cover of Nature BME! AI-clinician collaboration paper rdcu.be/dLgV1
We discuss how to conduct intersectional analysis in science and technology in @nature.com
nature.com/articles/s41...
I learned a ton from working w/ dream team co-authors! Great job by Londa Schiebinger + Mathias Nielson leading this project 👏 Also thanks @meharpist.bsky.social for guidance!
nature.com/articles/s41...
I learned a ton from working w/ dream team co-authors! Great job by Londa Schiebinger + Mathias Nielson leading this project 👏 Also thanks @meharpist.bsky.social for guidance!
Intersectional analysis for science and technology - Nature
This Perspective offers a guide for researchers, peer-reviewed journals and funding agencies to make quantitative intersectional approaches a standard part of science and technology research design, w...
nature.com
April 10, 2025 at 4:43 PM
We discuss how to conduct intersectional analysis in science and technology in @nature.com
nature.com/articles/s41...
I learned a ton from working w/ dream team co-authors! Great job by Londa Schiebinger + Mathias Nielson leading this project 👏 Also thanks @meharpist.bsky.social for guidance!
nature.com/articles/s41...
I learned a ton from working w/ dream team co-authors! Great job by Londa Schiebinger + Mathias Nielson leading this project 👏 Also thanks @meharpist.bsky.social for guidance!
Here's the non-paywall version of our #TextGrad paper rdcu.be/efRp4! 📜
April 2, 2025 at 4:01 PM
Here's the non-paywall version of our #TextGrad paper rdcu.be/efRp4! 📜