Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes:

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

If you're struggling to visualise mouse NMJs, we've got a protocol just for you!

bio-protocol.org/en/bpdetail?...

Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis

Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬

Yet another very proud supervisor moment - congratulations to Qiuhan Lang for passing her viva with flying colours today!

Thank you very much to examiners @tomgillingwater.bsky.social and Tom Cunningham

Very proud of team member Dr. Ellie Rhymes for coming Highly Commended in MDUK's Early Career Scientist of the Year Award:

www.musculardystrophyuk.org/news/preside...

@mdukcharity.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.

Endosome transport becomes impaired between 18 and 22 months, manifesting as increased pausing.

To determine the impact of aging, we assessed axonal transport of signalling endosomes in motor neurons of aneasthetised mice from 3 to 22 months.

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.biorxiv.org/content/10.1...

Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.

@uclqsion.bsky.social #aging

Short perspective from Dr. Ellie Rhymes on shared mechanisms and phenotypes in ARS-related neuropathies:

journals.lww.com/nrronline/ci...

#CMT #neuropathy #PeripheralNerve