James Nathan
@jamesnathanlab.bsky.social
Professor of Respiratory Medicine, University of Cambridge.
Cellular mechanisms of oxygen sensing and metabolism.
Cellular mechanisms of oxygen sensing and metabolism.
Congratulations Emma and Ziqi!
October 11, 2025 at 2:04 PM
Congratulations Emma and Ziqi!
Thanks to all members of the Nathan lab and our wonderful collaborators. #hypoxia #metabolism.
November 27, 2024 at 2:23 PM
Thanks to all members of the Nathan lab and our wonderful collaborators. #hypoxia #metabolism.
Third - our work examining synthetic lethality with VHL in renal cancer, uncovering a role for CBFB as a suppressor of Type I interferon signalling. www.biorxiv.org/content/10.1...
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING
Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau ( VHL ) tumour suppressor gene. Here, we und...
www.biorxiv.org
November 27, 2024 at 2:23 PM
Third - our work examining synthetic lethality with VHL in renal cancer, uncovering a role for CBFB as a suppressor of Type I interferon signalling. www.biorxiv.org/content/10.1...
Second - our work with Randall Johnson's group uncovering a novel role for how ABHD11 controls #lipoylation by acting as a lipoyl deglutarylating enzyme to regulate the TCA cycle. www.biorxiv.org/content/10.1...
ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism
Glutarate is an intermediate of amino acid catabolism and an important metabolite for reprogramming T cell immunity, exerting its effects by inhibition of histone demethylase enzymes or through glutar...
www.biorxiv.org
November 27, 2024 at 2:23 PM
Second - our work with Randall Johnson's group uncovering a novel role for how ABHD11 controls #lipoylation by acting as a lipoyl deglutarylating enzyme to regulate the TCA cycle. www.biorxiv.org/content/10.1...