Jaison J Sequeira
@jaisonjseq.bsky.social
Human population diversity is astonishing!
Reposted by Jaison J Sequeira
Pre @gensocuk.bsky.social talk @crick.ac.uk by Svante Pääbo, and interesting thoughts on how to define a “modern” human. More tomorrow!
November 13, 2025 at 8:43 PM
Pre @gensocuk.bsky.social talk @crick.ac.uk by Svante Pääbo, and interesting thoughts on how to define a “modern” human. More tomorrow!
Check out my blog summarising my experience at the SMBE2024 conference. You can also learn about my recent work on the Proto-Dravidian ancestry component. @official-smbe.bsky.social @mitopr.bsky.social @mashaals.bsky.social @ryangutenkunst.bsky.social popgenworld.blogspot.com/2025/11/from...
From Conference Attendee to Co-Author: The Journey I Never Expected
F or years, I dreamed of it: standing in a room full of international scientists, sharing my research, and being a part of the global conv...
popgenworld.blogspot.com
November 14, 2025 at 2:14 AM
Check out my blog summarising my experience at the SMBE2024 conference. You can also learn about my recent work on the Proto-Dravidian ancestry component. @official-smbe.bsky.social @mitopr.bsky.social @mashaals.bsky.social @ryangutenkunst.bsky.social popgenworld.blogspot.com/2025/11/from...
I am happy to share our manuscript summarising the outcome of GHIST2024 (ghist.bio). With so many statistical tools and software, population genetics research seems easy. But every case is different. The approaches used vary! doi.org/10.1093/molbev/msaf257 @ryangutenkunst.bsky.social
GHIST 2024: The First Genomic History Inference Strategies Tournament
Abstract. Evaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification,
doi.org
November 14, 2025 at 2:05 AM
I am happy to share our manuscript summarising the outcome of GHIST2024 (ghist.bio). With so many statistical tools and software, population genetics research seems easy. But every case is different. The approaches used vary! doi.org/10.1093/molbev/msaf257 @ryangutenkunst.bsky.social
Our article describing the "Proto-Dravidian" ancestry has been published in the European Journal of Human Genetics @ejhg-journal.bsky.social Here is a simplified summary of the scientific findings. #protodravidian #ivc #ancientcivilisation popgenworld.blogspot.com/2025/10/trac...
Tracing the Roots of the Koraga: The Discovery of a Lost Ancestor in India's Genetic Story
I n the lush, coastal districts of South India, the Koraga people have lived for generations on the margins. Historically labelled as "untou...
popgenworld.blogspot.com
October 26, 2025 at 7:54 AM
Our article describing the "Proto-Dravidian" ancestry has been published in the European Journal of Human Genetics @ejhg-journal.bsky.social Here is a simplified summary of the scientific findings. #protodravidian #ivc #ancientcivilisation popgenworld.blogspot.com/2025/10/trac...
We are migrants. We move to survive. All of us! Political boundaries do not define who we are, who we will be.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette
Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.
news.harvard.edu
September 21, 2025 at 6:24 AM
We are migrants. We move to survive. All of us! Political boundaries do not define who we are, who we will be.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
Reposted by Jaison J Sequeira
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya | Science www.science.org/doi/10.1126/...
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya
The Turkana pastoralists of Kenya inhabit arid, water-limited environments and rely largely on livestock for subsistence. Working with Turkana communities, we sequenced 367 whole genomes and identifie...
www.science.org
September 20, 2025 at 12:03 AM
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya | Science www.science.org/doi/10.1126/...
Reposted by Jaison J Sequeira
Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...
Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications
Multi-ancestry GWASs enhance discovery in diverse populations, but optimal methods
remain debated. Using theory, simulations, and analyses from the UK Biobank and All
of Us, we show that pooled analys...
www.cell.com
September 2, 2025 at 3:26 PM
Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...
Reposted by Jaison J Sequeira
Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
SPAAM Summer School (2025): Introduction to Ancient Metagenomics
Share your videos with friends, family, and the world
tinyurl.com
September 2, 2025 at 12:57 PM
Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM
Reposted by Jaison J Sequeira
Nice review of polygenic prediction of traits based on ancient DNA, by @mathiesoniain.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Polygenic prediction of human complex traits using ancient DNA
Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article,…
www.sciencedirect.com
September 1, 2025 at 8:47 AM
Nice review of polygenic prediction of traits based on ancient DNA, by @mathiesoniain.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jaison J Sequeira
A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...
Our paper is out! We linked genetic and linguistic data to study how contact changes language and found consistent patterns of borrowing across contact situations
@balthasarbickel.bsky.social @chiarabarbieri.bsky.social @nccrlanguage.bsky.social @isle-uzh.bsky.social
doi.org/10.1126/sciadv.adv7521
@balthasarbickel.bsky.social @chiarabarbieri.bsky.social @nccrlanguage.bsky.social @isle-uzh.bsky.social
doi.org/10.1126/sciadv.adv7521
Patterns of genetic admixture reveal similar rates of borrowing across diverse scenarios of language contact
Human population contact leads to consistently similar rates of linguistic borrowing, but effects vary across linguistic features.
www.science.org
August 30, 2025 at 1:56 PM
A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...
Happy to share our paper on the genetics of the gotra system in India. The study shows that the 'gotra' played a significant role in shaping the paternal lineage in Indian brahmins. 1/3 #gotra doi.org/10.1007/s004...
Exploring the genetic footprints of the gotra system in the Koṅkaṇī Sārasvata Brahmins - Molecular Genetics and Genomics
The gotra system of exogamy is followed by the Brahmin caste group in India. This system restricts the marriage of individuals who belong to the same gotra. In genetic terms, each gotra forms an exoga...
doi.org
August 12, 2025 at 12:29 PM
Happy to share our paper on the genetics of the gotra system in India. The study shows that the 'gotra' played a significant role in shaping the paternal lineage in Indian brahmins. 1/3 #gotra doi.org/10.1007/s004...
This is how @ryangutenkunst.bsky.social and the #GHIST team make science fun and productive. Thank you Ekaterina Noskova for making me a part of the #GADMA team!
GHIST 2024: The 1st Genomic History Inference Strategies Tournament https://www.biorxiv.org/content/10.1101/2025.08.05.668560v1
August 12, 2025 at 2:23 AM
This is how @ryangutenkunst.bsky.social and the #GHIST team make science fun and productive. Thank you Ekaterina Noskova for making me a part of the #GADMA team!
"Churning" the past for answers. An interesting chapter on samudramanthana and the connection between milk and snakes in Indo-European heritage. #IndoEuropean #IndoIranian #rigveda
stockholmuniversitypress.se/reader/chapt...
stockholmuniversitypress.se/reader/chapt...
https://stockholmuniversitypress.se/chapters/e/10.…
August 7, 2025 at 2:14 PM
"Churning" the past for answers. An interesting chapter on samudramanthana and the connection between milk and snakes in Indo-European heritage. #IndoEuropean #IndoIranian #rigveda
stockholmuniversitypress.se/reader/chapt...
stockholmuniversitypress.se/reader/chapt...
Reposted by Jaison J Sequeira
I'm so proud to see this paper published! Hopefully, it can inspire a positive change in the field of #palaeoproteomics, through open science and researchers working together instead of against each other. Huge thanks and congrats to all coauthors! 🎉
Delighted to be bringing you the following PAASTA community-led paper outlining our recommendations for best practices and open science in palaeoproteomics! Congratulations to the authors and for anyone keen to read the paper, it can be found #OpenAccess here: doi.org/10.24072/pcj...
August 6, 2025 at 9:27 AM
I'm so proud to see this paper published! Hopefully, it can inspire a positive change in the field of #palaeoproteomics, through open science and researchers working together instead of against each other. Huge thanks and congrats to all coauthors! 🎉
Reposted by Jaison J Sequeira
#MetagenomicsMonday Analysis of aDNA from 1313 ancient human remains spanning 37k years revealed that the rise of infectious diseases coincided with animal domestication around 65k years ago, with disease spread intensifying during pastoralist migrations.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The spatiotemporal distribution of human pathogens in ancient Eurasia - Nature
Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and zoonotic pathogens…
www.nature.com
August 4, 2025 at 7:01 AM
#MetagenomicsMonday Analysis of aDNA from 1313 ancient human remains spanning 37k years revealed that the rise of infectious diseases coincided with animal domestication around 65k years ago, with disease spread intensifying during pastoralist migrations.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jaison J Sequeira
New research from Priya Moorjani's lab offers insights into India’s genomic legacy.
Postdocs @lauritsskov.bsky.social and @ekerdoncuff.bsky.social traced Indian's ancestry to three main sources. Read the findings in this story by grad student Jules Perez: bit.ly/3IK46vh
Postdocs @lauritsskov.bsky.social and @ekerdoncuff.bsky.social traced Indian's ancestry to three main sources. Read the findings in this story by grad student Jules Perez: bit.ly/3IK46vh
July 24, 2025 at 6:48 PM
New research from Priya Moorjani's lab offers insights into India’s genomic legacy.
Postdocs @lauritsskov.bsky.social and @ekerdoncuff.bsky.social traced Indian's ancestry to three main sources. Read the findings in this story by grad student Jules Perez: bit.ly/3IK46vh
Postdocs @lauritsskov.bsky.social and @ekerdoncuff.bsky.social traced Indian's ancestry to three main sources. Read the findings in this story by grad student Jules Perez: bit.ly/3IK46vh
Reposted by Jaison J Sequeira
Vanessa Villalba-Mouco and I wrote a little preview piece for Cell on the new mtDNA and proteomics results from the Harbin skull. It is free for 50 days at this link: www.sciencedirect.com/science/arti...
Unmasking the Denisovans
The Harbin cranium, linked to Denisovans via mitochondrial DNA, broadens their known range and provides the first insights into Denisovan morphology. …
www.sciencedirect.com
July 24, 2025 at 9:26 PM
Vanessa Villalba-Mouco and I wrote a little preview piece for Cell on the new mtDNA and proteomics results from the Harbin skull. It is free for 50 days at this link: www.sciencedirect.com/science/arti...
"Surprisingly, the resolution of rare variants is even higher than using all variants..." Excited to use this method on Indian population data! @stschiff.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
High resolution analysis of population structure using rare variants
Various statistical methods have been developed to identify population structure from genetic data, including F-statistics, which measure the average correlation in allele frequency differences betwee...
www.biorxiv.org
July 24, 2025 at 2:07 AM
"Surprisingly, the resolution of rare variants is even higher than using all variants..." Excited to use this method on Indian population data! @stschiff.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jaison J Sequeira
Our latest articles on Whole genome sequencing and assembly of the house sparrow, Passer domesticus
#passer
gigabytejournal.com/articles/161
#passer
gigabytejournal.com/articles/161
Whole genome sequencing and assembly of the house sparrow, Passer domesticus
Whole genome sequencing and assembly of the house sparrow, Passer domesticus
gigabytejournal.com
July 22, 2025 at 9:11 AM
Our latest articles on Whole genome sequencing and assembly of the house sparrow, Passer domesticus
#passer
gigabytejournal.com/articles/161
#passer
gigabytejournal.com/articles/161
Reposted by Jaison J Sequeira
Two useful new reviews on ancestry inference in population genetics:
onlinelibrary.wiley.com/doi/10.1111/...
genomebiology.biomedcentral.com/articles/10....
onlinelibrary.wiley.com/doi/10.1111/...
genomebiology.biomedcentral.com/articles/10....
July 17, 2025 at 2:57 PM
Two useful new reviews on ancestry inference in population genetics:
onlinelibrary.wiley.com/doi/10.1111/...
genomebiology.biomedcentral.com/articles/10....
onlinelibrary.wiley.com/doi/10.1111/...
genomebiology.biomedcentral.com/articles/10....
A common misconception is that genetic drift/bottlenecks erase ancestral components. Yet the persistence of archaic ancestry in India's founder populations proves otherwise. Modern pops like Onge, Paniya, Koraga, Papuan preserve true relics of the human past, sometimes even better than aDNA.
July 13, 2025 at 7:03 AM
A common misconception is that genetic drift/bottlenecks erase ancestral components. Yet the persistence of archaic ancestry in India's founder populations proves otherwise. Modern pops like Onge, Paniya, Koraga, Papuan preserve true relics of the human past, sometimes even better than aDNA.
Reposted by Jaison J Sequeira
🌾 Agriculture didn’t always spread with mobility of people.
New ancient DNA research shows that in western Anatolia, while communities stayed put, farming and village life spread through the movement of ideas and practices.
New ancient DNA research shows that in western Anatolia, while communities stayed put, farming and village life spread through the movement of ideas and practices.
June 28, 2025 at 7:33 PM
🌾 Agriculture didn’t always spread with mobility of people.
New ancient DNA research shows that in western Anatolia, while communities stayed put, farming and village life spread through the movement of ideas and practices.
New ancient DNA research shows that in western Anatolia, while communities stayed put, farming and village life spread through the movement of ideas and practices.
Reposted by Jaison J Sequeira
Our paper out today: 50,000 years of evolutionary history of India: Impact on health and disease variation: Cell www.cell.com/cell/fulltex...
50,000 years of evolutionary history of India: Impact on health and disease variation
A genomic study of 2,762 individuals from India offers important insights into the
genomic diversity and evolutionary history of the subcontinent and highlights the
extensive genetic variation, gene f...
www.cell.com
June 26, 2025 at 3:27 PM
Our paper out today: 50,000 years of evolutionary history of India: Impact on health and disease variation: Cell www.cell.com/cell/fulltex...
Reposted by Jaison J Sequeira
Dragon Man was a Denisovan! DNA and proteins both confirm it, giving this mysterious human lineage a face at long last. Here’s my story. [Gift link] nyti.ms/44nQq1i
June 18, 2025 at 3:09 PM
Dragon Man was a Denisovan! DNA and proteins both confirm it, giving this mysterious human lineage a face at long last. Here’s my story. [Gift link] nyti.ms/44nQq1i