Manish Goel
itsmanishgoel.bsky.social
Manish Goel
@itsmanishgoel.bsky.social
Genomics, bioinformatics, and some more
Reposted by Manish Goel
Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu.

Explained for non-experts!
July 1, 2025 at 10:27 AM
Reposted by Manish Goel
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🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇
doi.org
June 5, 2025 at 8:47 AM
Reposted by Manish Goel
How does cryptic genetic variation influence the long-term fate of gene duplicates (paralogs)?
Our new study addresses this question by dissecting the evolutionary potential of redundant myosin paralogs in yeast nature.com/articles/s41... (1/12)
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network - Nature Communications
Over time, paralogous genes accumulate changes in their sequences that do not affect their function, which is called cryptic variation. Using paralogous myosins, this study shows how cryptic variation...
nature.com
June 1, 2025 at 11:27 PM
Reposted by Manish Goel
This week on the pod:

🥔 A potato pangenome
📄 The top cited twenty-first century research papers
https://go.nature.com/4j9z50Z
What a trove of potato genomes reveals about the humble spud
Hear the biggest stories from the world of science | 16 April 2025
go.nature.com
April 16, 2025 at 4:00 PM
Reposted by Manish Goel
📢 Excited to share our work out now in @nature.com! 📢

We present the phased pan-genome of tetraploid European potato, based on 10 historical cultivars representing 85% of European potato diversity.

Learn more below!

🔗 www.nature.com/articles/s41...

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The phased pan-genome of tetraploid European potato - Nature
A haplotype-resolved pan-genome of autotetraploid European potato founder lines shows high nucleotide diversity at remarkably low haplotype diversity, which is probably the result of hybridization eve...
www.nature.com
April 16, 2025 at 3:14 PM
Reposted by Manish Goel
PhDs are paid positions, enough to live comfortably even in a big city like Vienna, and include all health insurance, social benefits, pension contributions. Usually with low to no teaching requirements (but opportunities to get involved if interested!). Main focus is your research.
March 1, 2025 at 8:31 AM
Reposted by Manish Goel
Perhaps if helps at this point to outline how the academic path works outside the US. I can speak for Austria, but many EU countries are similar. Students usually do a BSc (3 yrs) then an MSc (2 yrs) then apply for PhD positions (range 3-5 yrs, average around 4).
March 1, 2025 at 8:31 AM
I worked in Max-Planck Institute for seven years and loved every day of it. For anyone getting affected by the current changes, I can strongly recommend @maxplanck.de
February 15, 2025 at 10:52 AM
Reposted by Manish Goel
February 15, 2025 at 2:12 AM
Reposted by Manish Goel
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
go.nature.com
January 24, 2025 at 11:52 AM
Reposted by Manish Goel
Congratulations to Koneru Humpy for winning the FIDE Women's World Rapid Chess Championship 2024 - for the second time after 2019! 🎉 https://lichess.org/broadcast/fide-world-rapid--blitz-championships-2024--rapid-women/round-11/0eCc1imU/sJNJUFmi
December 28, 2024 at 11:03 PM
Reposted by Manish Goel

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
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High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Reposted by Manish Goel
Long-context xLSTM models of DNA, proteins, and chemicals.
@smdrnks.bsky.social @phseidl.bsky.social @gklambauer.bsky.social

arxiv.org/abs/2411.04165
November 20, 2024 at 10:11 PM