Seth Thomas Scanlon
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immunoeditor.bsky.social
Seth Thomas Scanlon
@immunoeditor.bsky.social
2.8K followers 250 following 210 posts
Editor, Science Immunology
science.org/journal/sciimmunol

🇺🇸 + 🇳🇱 & based in 🇪🇺

Twitter: x.com/ImmunoEditor
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immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Nov 14
At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow!

www.science.org/journal/scii...
The Science Immunology editors in front of AAAS Headquarters in Washington DC. (L to R): Chris Fogg, Claire Olingy, Seth Thomas Scanlon, & Hannah Isles
immunoeditor.bsky.social
Nov issue of #Science #Immunology out now!

This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!

scim.ag/4qQA6Q6
ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end. Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University
November 7, 2025 at 10:19 PM
immunoeditor.bsky.social
Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation!
#asthma #immunometabolism
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.
www.science.org
October 24, 2025 at 6:54 PM
immunoeditor.bsky.social
Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.
www.science.org
October 24, 2025 at 5:26 PM
immunoeditor.bsky.social
Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy!

Xie & al.
scim.ag/3W7wfQl

Sutton & al.
scim.ag/4ofvKQa
October 24, 2025 at 5:19 PM
immunoeditor.bsky.social
I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology!

swimm.se/ssi-2025/

@finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se
Main stage of the Aula Medica auditorium in Stockholm, Sweden. Three people are standing near the lectern on stage. Text on the screen above the stage reads "50th annual meeting of the Scandinavian Society for Immunology" and features the SSI logo.
October 15, 2025 at 7:38 AM
immunoeditor.bsky.social
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!

bit.ly/SciImm_free
October 9, 2025 at 5:43 PM
immunoeditor.bsky.social
Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!
October 6, 2025 at 10:04 AM
immunoeditor.bsky.social
This week in #Science #Immunology! 👇
kischober.bsky.social Kilian Schober @kischober.bsky.social · Oct 3
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 4, 2025 at 10:45 AM
immunoeditor.bsky.social
The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP
Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain. Credit: Rioka Hayama
October 3, 2025 at 8:08 PM
immunoeditor.bsky.social
David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!
Design of a potent interleukin-21 mimic for cancer immunotherapy
A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
www.science.org
September 29, 2025 at 9:13 PM
immunoeditor.bsky.social
Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system
ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.
www.science.org
September 29, 2025 at 9:02 PM
immunoeditor.bsky.social
Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!
Inhibitory immune checkpoints in cancer immunotherapy
Inhibitory immune checkpoints for cancer immunotherapy are reviewed.
www.science.org
September 29, 2025 at 8:50 PM
immunoeditor.bsky.social
Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!
Nuclear polarization to the immune synapse facilitates an early transcriptional burst
Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.
www.science.org
September 19, 2025 at 8:54 PM
immunoeditor.bsky.social
Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
www.science.org
September 19, 2025 at 7:53 PM
immunoeditor.bsky.social
The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis

scim.ag/3HKC5DP
Shining a Light on Naïve T Cell Homeostasis: Homeostatic maintenance of naïve T cells is critical to maintain a large and diverse T cell pool. However, the underlying mechanisms regulating this process are not well understood. Wu et al. report that the RNA helicase DDX55 regulates the homeostatic maintenance of naïve T cells by preventing MYC from binding to enhancer- and promoter-like transposable elements (TEs) near T cell activation genes. In naïve T cells, DDX55 prevents the inappropriate activation of TEs and ensures their genomic stability by preventing R-loop formation. This month’s cover features a light bulb with its filament stylized as a DNA double helix. Its left half glows with an intact filament, symbolizing TEs as regulators, and its right side is dimmed and features a broken filament, representing TEs’ disruptive potential. Credit: Bingyu Yang and Jianling Zhu/Sichuan University
September 5, 2025 at 6:23 PM
immunoeditor.bsky.social
Way to go, @cnfogg.bsky.social!
nerdychristie.bsky.social Christie Wilcox @nerdychristie.bsky.social · Aug 29
In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪
Christiana Fogg, 11.7 miles into the 2024 Stone Mill 50-miler. Photo: Dan Reichmann, MCRRC
August 30, 2025 at 11:53 AM
immunoeditor.bsky.social
Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!
recruiting.ultipro.com
August 29, 2025 at 7:44 AM
immunoeditor.bsky.social
Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!
Home - IUIS 2025
IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...
iuis2025.org
August 15, 2025 at 6:58 PM
immunoeditor.bsky.social
This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!

scim.ag/3UqRrA6
COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586. Illustration: Rioka Hayama
August 12, 2025 at 8:32 PM
immunoeditor.bsky.social
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...
August 1, 2025 at 8:21 PM
immunoeditor.bsky.social
Out now in #Science #Immunology: Eric Vivier (@univ-amu.fr), Hui Peng, Zhigang Tian (USTC, Hefei), & colleagues report that #FetalLiver #InnateLymphoidCell ( #ILC ) progenitors in mice continue contributing to ILC #hematopoiesis into adulthood in a #BoneMarrow –independent manner!
Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors
Fetal liver–derived ILC progenitors seed peripheral tissues and generate local ILCs independently of the bone marrow throughout life.
www.science.org
July 17, 2025 at 7:20 PM
immunoeditor.bsky.social
In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!
Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.
www.science.org
July 4, 2025 at 11:17 PM
immunoeditor.bsky.social
The July issue of #Science #Immunology is out now! This week:

• Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy!

• Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut!

New content each week!

www.science.org/toc/sciimmun...
Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white). Credit: A. Fisher/Science Immunology
July 4, 2025 at 10:34 PM
immunoeditor.bsky.social
I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵

温かく迎えてくれた主催者に感謝する！
June 27, 2025 at 2:44 AM
immunoeditor.bsky.social
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025

bit.ly/SciImm_free
June 25, 2025 at 1:56 PM