Ieva Drulyte
@ievadr.bsky.social
Structural biologist | CryoCloud 🔬☁️ | Posts about #cryoEM, some running and cats | Views my own | She/her
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
November 24, 2025 at 3:17 PM
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
A few snaps from @cryocloudio.bsky.social retreat in the Belgian Ardennes 📸🌿
We mixed focused work sessions with walks and shared meals, late-night Jenga battles, and plenty of time socialising. We even spotted deer in the garden 🦌
And yes, we also launched our own #cryoEM socks!
We mixed focused work sessions with walks and shared meals, late-night Jenga battles, and plenty of time socialising. We even spotted deer in the garden 🦌
And yes, we also launched our own #cryoEM socks!
September 18, 2025 at 8:59 AM
A few snaps from @cryocloudio.bsky.social retreat in the Belgian Ardennes 📸🌿
We mixed focused work sessions with walks and shared meals, late-night Jenga battles, and plenty of time socialising. We even spotted deer in the garden 🦌
And yes, we also launched our own #cryoEM socks!
We mixed focused work sessions with walks and shared meals, late-night Jenga battles, and plenty of time socialising. We even spotted deer in the garden 🦌
And yes, we also launched our own #cryoEM socks!
Another nice example is this publication on garadacimab, where we showed what happened at different FOM concentrations (Fig. S3).
Image taken from the preprint: www.biorxiv.org/content/10.1...
Publication in Structure: www.cell.com/structure/ab...
Image taken from the preprint: www.biorxiv.org/content/10.1...
Publication in Structure: www.cell.com/structure/ab...
July 16, 2025 at 7:13 AM
Another nice example is this publication on garadacimab, where we showed what happened at different FOM concentrations (Fig. S3).
Image taken from the preprint: www.biorxiv.org/content/10.1...
Publication in Structure: www.cell.com/structure/ab...
Image taken from the preprint: www.biorxiv.org/content/10.1...
Publication in Structure: www.cell.com/structure/ab...
Excited to share that our book chapter on #cryoEM epitope mapping, co‑written with my favourite collaborator @danielhurdiss.bsky.social, is now out! 🔬
It captures learnings from many biologics projects & we hope it’s a useful resource for structural immunologists!
link.springer.com/protocol/10....
It captures learnings from many biologics projects & we hope it’s a useful resource for structural immunologists!
link.springer.com/protocol/10....
July 16, 2025 at 7:11 AM
Excited to share that our book chapter on #cryoEM epitope mapping, co‑written with my favourite collaborator @danielhurdiss.bsky.social, is now out! 🔬
It captures learnings from many biologics projects & we hope it’s a useful resource for structural immunologists!
link.springer.com/protocol/10....
It captures learnings from many biologics projects & we hope it’s a useful resource for structural immunologists!
link.springer.com/protocol/10....
Early morning sightseeing jog through Strasbourg with @riborob.bsky.social 📸
Quiet streets, cathedral views, and a good way to reset before we head into day two of #NovalixConference!
Fueled by Alsace cuisine, and maybe a pretzel or two from the welcome reception 🥨
#Novalix2025 #CryoEM
Quiet streets, cathedral views, and a good way to reset before we head into day two of #NovalixConference!
Fueled by Alsace cuisine, and maybe a pretzel or two from the welcome reception 🥨
#Novalix2025 #CryoEM
May 21, 2025 at 8:45 AM
Early morning sightseeing jog through Strasbourg with @riborob.bsky.social 📸
Quiet streets, cathedral views, and a good way to reset before we head into day two of #NovalixConference!
Fueled by Alsace cuisine, and maybe a pretzel or two from the welcome reception 🥨
#Novalix2025 #CryoEM
Quiet streets, cathedral views, and a good way to reset before we head into day two of #NovalixConference!
Fueled by Alsace cuisine, and maybe a pretzel or two from the welcome reception 🥨
#Novalix2025 #CryoEM
3rd year running the #UtrechtMarathon 🏃♀️ This year feels extra special since I now work right here on Utrecht Science Park, where the race starts and finishes!
⏱️ Back to the 10k this year (49:18)
Well done to my @cryocloudio.bsky.social teammates @riborob.bsky.social & Thijmen on the half marathon!
⏱️ Back to the 10k this year (49:18)
Well done to my @cryocloudio.bsky.social teammates @riborob.bsky.social & Thijmen on the half marathon!
May 19, 2025 at 7:30 AM
3rd year running the #UtrechtMarathon 🏃♀️ This year feels extra special since I now work right here on Utrecht Science Park, where the race starts and finishes!
⏱️ Back to the 10k this year (49:18)
Well done to my @cryocloudio.bsky.social teammates @riborob.bsky.social & Thijmen on the half marathon!
⏱️ Back to the 10k this year (49:18)
Well done to my @cryocloudio.bsky.social teammates @riborob.bsky.social & Thijmen on the half marathon!
After 6.5 incredible years, this is my final week at Thermo Fisher. It’s been a rewarding journey - working with brilliant people and witnessing the #cryoEM revolution impact drug discovery 🔬
Next up: @cryocloudio.bsky.social. Excited for what’s ahead!
Next up: @cryocloudio.bsky.social. Excited for what’s ahead!
April 23, 2025 at 7:42 AM
After 6.5 incredible years, this is my final week at Thermo Fisher. It’s been a rewarding journey - working with brilliant people and witnessing the #cryoEM revolution impact drug discovery 🔬
Next up: @cryocloudio.bsky.social. Excited for what’s ahead!
Next up: @cryocloudio.bsky.social. Excited for what’s ahead!
Proud to be one of the authors of the highest-resolution SARS-CoV-2 #cryoEM entry on EMDB 😄 This came out of a fun collaboration with Bicycle Therapeutics, where we used cryo-EM to validate binding of their biparatopic (EMD-51660) and homotrimeric (EMD-51659) Bicycle molecules 🔬
April 4, 2025 at 11:38 AM
Proud to be one of the authors of the highest-resolution SARS-CoV-2 #cryoEM entry on EMDB 😄 This came out of a fun collaboration with Bicycle Therapeutics, where we used cryo-EM to validate binding of their biparatopic (EMD-51660) and homotrimeric (EMD-51659) Bicycle molecules 🔬
🌌 Seeing cryo-EM picking up on Bluesky, it's time for a reintroduction! 👋 I'm Ieva, a structural biologist (former crystallographer turned cryo-EM aficionado since 2014). I work at Thermo Fisher Scientific and am passionate about advancing #cryoEM & #cryoET applications in #DrugDiscovery 🔬💊
November 14, 2024 at 9:11 AM
🌌 Seeing cryo-EM picking up on Bluesky, it's time for a reintroduction! 👋 I'm Ieva, a structural biologist (former crystallographer turned cryo-EM aficionado since 2014). I work at Thermo Fisher Scientific and am passionate about advancing #cryoEM & #cryoET applications in #DrugDiscovery 🔬💊
We are celebrating 75 Years of TEM Innovation in Eindhoven 🔬🎆
I am honoured to be part of history, both figuratively and literally (top right corner of the poster)!🤓
I am honoured to be part of history, both figuratively and literally (top right corner of the poster)!🤓
November 22, 2024 at 11:06 AM
We are celebrating 75 Years of TEM Innovation in Eindhoven 🔬🎆
I am honoured to be part of history, both figuratively and literally (top right corner of the poster)!🤓
I am honoured to be part of history, both figuratively and literally (top right corner of the poster)!🤓
Back from the 10th-anniversary edition of the @novalix_pharma conference Biophysics in Drug Discovery. Really enjoyed spending a few days in the beautiful Brunnen and listening to talks from the legends in drug discovery!
#NovAliXConference #AI #PROTACs #StructuralBiology
#NovAliXConference #AI #PROTACs #StructuralBiology
November 22, 2024 at 11:06 AM
Back from the 10th-anniversary edition of the @novalix_pharma conference Biophysics in Drug Discovery. Really enjoyed spending a few days in the beautiful Brunnen and listening to talks from the legends in drug discovery!
#NovAliXConference #AI #PROTACs #StructuralBiology
#NovAliXConference #AI #PROTACs #StructuralBiology
Happy to be back at the #CCPEM Spring Symposium, reconecting with familiar faces and meeting new ones! A special shoutout to @SubangstromLLC for these very stylish and *much in demand* earrings! 🤩
November 22, 2024 at 11:06 AM
Happy to be back at the #CCPEM Spring Symposium, reconecting with familiar faces and meeting new ones! A special shoutout to @SubangstromLLC for these very stylish and *much in demand* earrings! 🤩
Excited to attend the #MedChemFrontiers2024 in Utrecht this week! 🚀 If you are here too, do not miss the #cryoEM workshop on April 9, and stop by the @thermofisher booth for a chat and a stroopwafel 😊🍯
November 22, 2024 at 11:06 AM
Excited to attend the #MedChemFrontiers2024 in Utrecht this week! 🚀 If you are here too, do not miss the #cryoEM workshop on April 9, and stop by the @thermofisher booth for a chat and a stroopwafel 😊🍯
Do not miss this webinar on April 3 with @generate_biomed and @DrugDiscovNews! Register to learn about filling critical gaps in medical treatment using AI technologies to accelerate drug development. 💊 https://bit.ly/3IXP9mh
November 22, 2024 at 11:13 AM
Do not miss this webinar on April 3 with @generate_biomed and @DrugDiscovNews! Register to learn about filling critical gaps in medical treatment using AI technologies to accelerate drug development. 💊 https://bit.ly/3IXP9mh
With International Women's Day just around the corner, you can request a limited edition #IWD2024 pin from @thermofisher in celebration of women scientists in #ElectronMicroscopy. Post a photo with your pin using #EmpowerWomenInEM! T&C apply. https://bit.ly/3T72D3N
November 22, 2024 at 11:13 AM
With International Women's Day just around the corner, you can request a limited edition #IWD2024 pin from @thermofisher in celebration of women scientists in #ElectronMicroscopy. Post a photo with your pin using #EmpowerWomenInEM! T&C apply. https://bit.ly/3T72D3N
👀 Low Energy Spread cold FEG (E-CFEG) is now an option for Glacios 2. Pictured: apoferritin at 1.5 Å #cryoEM https://bit.ly/49gQvUz
November 22, 2024 at 11:14 AM
👀 Low Energy Spread cold FEG (E-CFEG) is now an option for Glacios 2. Pictured: apoferritin at 1.5 Å #cryoEM https://bit.ly/49gQvUz
See new research results from @SchurLab / @ISTAustria that uncovers the architecture of the poxvirus core using #cryoEM and molecular modeling.
To date, knowledge about the structural proteins that form the viral core has remained sparse. https://go.nature.com/3HSRgah
To date, knowledge about the structural proteins that form the viral core has remained sparse. https://go.nature.com/3HSRgah
November 22, 2024 at 11:14 AM
See new research results from @SchurLab / @ISTAustria that uncovers the architecture of the poxvirus core using #cryoEM and molecular modeling.
To date, knowledge about the structural proteins that form the viral core has remained sparse. https://go.nature.com/3HSRgah
To date, knowledge about the structural proteins that form the viral core has remained sparse. https://go.nature.com/3HSRgah
Applications are now open for the 2024 .@thermofisher’s #cryoEM Grant Program! See official rules for detailed eligibility requirements. https://bit.ly/3S9PhnY
November 22, 2024 at 11:22 AM
Applications are now open for the 2024 .@thermofisher’s #cryoEM Grant Program! See official rules for detailed eligibility requirements. https://bit.ly/3S9PhnY
Highly recommend this webinar!! Watch Adam Root from @generate_biomed talk about combining #AI, #MachineLearning and #cryoEM 🚀🔬 https://bit.ly/3NpNVCN
November 22, 2024 at 11:22 AM
Highly recommend this webinar!! Watch Adam Root from @generate_biomed talk about combining #AI, #MachineLearning and #cryoEM 🚀🔬 https://bit.ly/3NpNVCN
Structural analysis with other bonafide FXIIa inhibitors, such as benzamidine and C1-INH, reveals a conserved mechanism of βFXIIa inhibition, a novel finding of this study.
November 22, 2024 at 12:22 PM
Structural analysis with other bonafide FXIIa inhibitors, such as benzamidine and C1-INH, reveals a conserved mechanism of βFXIIa inhibition, a novel finding of this study.
Garadacimab binds to βFXIIa through an unusually long CDR-H3 that inserts into the S1 pocket in a non-canonical way. This atypical structural mechanism is likely the primary contributor in the inhibition of activated FXII proteolytic activity in HAE.
November 22, 2024 at 12:14 PM
Garadacimab binds to βFXIIa through an unusually long CDR-H3 that inserts into the S1 pocket in a non-canonical way. This atypical structural mechanism is likely the primary contributor in the inhibition of activated FXII proteolytic activity in HAE.
In this study, led by the team at @CSL, we describe a 2.6 Å #cryoEM structure of βFXIIa complexed with the Fab fragment of garadacimab.
We observed three distinct garadacimab Fab-βFXIIa complexes and the C2-symmetric dimer chosen for epitope-paratope interface characterisation.
We observed three distinct garadacimab Fab-βFXIIa complexes and the C2-symmetric dimer chosen for epitope-paratope interface characterisation.
November 22, 2024 at 12:06 PM
In this study, led by the team at @CSL, we describe a 2.6 Å #cryoEM structure of βFXIIa complexed with the Fab fragment of garadacimab.
We observed three distinct garadacimab Fab-βFXIIa complexes and the C2-symmetric dimer chosen for epitope-paratope interface characterisation.
We observed three distinct garadacimab Fab-βFXIIa complexes and the C2-symmetric dimer chosen for epitope-paratope interface characterisation.
Garadacimab, a novel, fully human recombinant monoclonal #antibody inhibitor of human-activated Factor XII (FXIIa), has recently completed its Phase 3 trial for the prophylactic treatment of Hereditary Angioedema (HAE) patients with C1-INH deficiency...
November 22, 2024 at 11:31 AM
Garadacimab, a novel, fully human recombinant monoclonal #antibody inhibitor of human-activated Factor XII (FXIIa), has recently completed its Phase 3 trial for the prophylactic treatment of Hereditary Angioedema (HAE) patients with C1-INH deficiency...
Excited to share the results of a collaboration with @CSL:
Structural basis for inhibition of βFXIIa by garadacimab
https://www.biorxiv.org/content/10.1101/2023.12.03.569829v1
#garadacimab #antibody #cryoEM 🔬
A thread...🧵
Structural basis for inhibition of βFXIIa by garadacimab
https://www.biorxiv.org/content/10.1101/2023.12.03.569829v1
#garadacimab #antibody #cryoEM 🔬
A thread...🧵
November 22, 2024 at 11:22 AM
Excited to share the results of a collaboration with @CSL:
Structural basis for inhibition of βFXIIa by garadacimab
https://www.biorxiv.org/content/10.1101/2023.12.03.569829v1
#garadacimab #antibody #cryoEM 🔬
A thread...🧵
Structural basis for inhibition of βFXIIa by garadacimab
https://www.biorxiv.org/content/10.1101/2023.12.03.569829v1
#garadacimab #antibody #cryoEM 🔬
A thread...🧵
#PSDI23 has come to an end, but not without a last round of beers before catching our flights back home. See you all next year in Paris! ✈️ @IgorNederlof @ribo_rob
November 22, 2024 at 11:31 AM
#PSDI23 has come to an end, but not without a last round of beers before catching our flights back home. See you all next year in Paris! ✈️ @IgorNederlof @ribo_rob