Harriette Van Spall MD MPH 🇨🇦
@hvanspall.bsky.social
Cardiologist, Clinical Trialist McMasterU. Heart failure, Cardiometabolic Disease, Implementation Science. Editor Circulation.
#Medtronic press release on our pivotal #ELEVATE-HFpEF RCT which will test the efficacy & safety of a personalized elevated #pacing rate (based on LVEF & height) in #HFpEF
75 countries
2 patients enrolled already (AUS & US)
Methods to be presented at #HFSA25
news.medtronic.com/2025-09-15-M...
75 countries
2 patients enrolled already (AUS & US)
Methods to be presented at #HFSA25
news.medtronic.com/2025-09-15-M...
September 17, 2025 at 9:25 PM
#Medtronic press release on our pivotal #ELEVATE-HFpEF RCT which will test the efficacy & safety of a personalized elevated #pacing rate (based on LVEF & height) in #HFpEF
75 countries
2 patients enrolled already (AUS & US)
Methods to be presented at #HFSA25
news.medtronic.com/2025-09-15-M...
75 countries
2 patients enrolled already (AUS & US)
Methods to be presented at #HFSA25
news.medtronic.com/2025-09-15-M...
FDA announces approval for #semaglutide 2.4 mg sc weekly for #MASLD based on results of the #ESSENCE #RCT.
Did you know that #CVD is the leading cause of death in patients with #MASLD?
Common mechanisms & now, common treatments for #CKLM diseases
www.novonordisk.com/news-and-med...
Did you know that #CVD is the leading cause of death in patients with #MASLD?
Common mechanisms & now, common treatments for #CKLM diseases
www.novonordisk.com/news-and-med...
August 16, 2025 at 2:36 PM
FDA announces approval for #semaglutide 2.4 mg sc weekly for #MASLD based on results of the #ESSENCE #RCT.
Did you know that #CVD is the leading cause of death in patients with #MASLD?
Common mechanisms & now, common treatments for #CKLM diseases
www.novonordisk.com/news-and-med...
Did you know that #CVD is the leading cause of death in patients with #MASLD?
Common mechanisms & now, common treatments for #CKLM diseases
www.novonordisk.com/news-and-med...
I love my outdoor #office, where work and play are fully intertwined!
What does your #Saturday morning look like?
#HappySeason #HomeSweetHome #JoyInWork
What does your #Saturday morning look like?
#HappySeason #HomeSweetHome #JoyInWork
June 14, 2025 at 12:01 PM
I love my outdoor #office, where work and play are fully intertwined!
What does your #Saturday morning look like?
#HappySeason #HomeSweetHome #JoyInWork
What does your #Saturday morning look like?
#HappySeason #HomeSweetHome #JoyInWork
Regional disparities in participant #enrolment in RCTs are related to regional #disparities in site recruitment relative to 🌎disease distribution
We propose estimating site representation index during trial planning to ensure globally (or nationally) representative #RCT popn
doi.org/10.1002/ejhf...
We propose estimating site representation index during trial planning to ensure globally (or nationally) representative #RCT popn
doi.org/10.1002/ejhf...
June 8, 2025 at 1:10 PM
Regional disparities in participant #enrolment in RCTs are related to regional #disparities in site recruitment relative to 🌎disease distribution
We propose estimating site representation index during trial planning to ensure globally (or nationally) representative #RCT popn
doi.org/10.1002/ejhf...
We propose estimating site representation index during trial planning to ensure globally (or nationally) representative #RCT popn
doi.org/10.1002/ejhf...
#NUDGECKD #ERA25 LBT #KristofferSkaar & #TorBiering
SimPub #Circulation
Pragmatic 2x2 factorial #implementation RCT
Randomization at cluster + individual level
E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i
www.ahajournals.org/doi/10.1161/...
SimPub #Circulation
Pragmatic 2x2 factorial #implementation RCT
Randomization at cluster + individual level
E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i
www.ahajournals.org/doi/10.1161/...
June 8, 2025 at 12:58 PM
#NUDGECKD #ERA25 LBT #KristofferSkaar & #TorBiering
SimPub #Circulation
Pragmatic 2x2 factorial #implementation RCT
Randomization at cluster + individual level
E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i
www.ahajournals.org/doi/10.1161/...
SimPub #Circulation
Pragmatic 2x2 factorial #implementation RCT
Randomization at cluster + individual level
E-letters re #GDMT to 1540 GPs & 22617 patients w #CKD did not ⬆️ uptake of #RASi or #SGLT2i
www.ahajournals.org/doi/10.1161/...
June 8, 2025 at 12:46 PM
June 7, 2025 at 10:49 AM
Ship of #tolerance, created by 2000 school children in our town and displayed in #OakvilleGalleries #GairlochGardens
Such a collaborative, moving art display, with ideas communicated in a way that only kids can do.
Such a collaborative, moving art display, with ideas communicated in a way that only kids can do.
June 1, 2025 at 8:17 PM
Ship of #tolerance, created by 2000 school children in our town and displayed in #OakvilleGalleries #GairlochGardens
Such a collaborative, moving art display, with ideas communicated in a way that only kids can do.
Such a collaborative, moving art display, with ideas communicated in a way that only kids can do.
May 11, 2025 at 10:35 AM
While #health systems across🌎 are designed around #acute illnesses, 86% of yrs lived w disability & 71% yrs of life lost are from #chronic diseases
Burden of chronic dz ⬆️ in higher income countries & w age
How to move needle? See our analysis @Nature.bsky.social
rdcu.be/ek1MH
Burden of chronic dz ⬆️ in higher income countries & w age
How to move needle? See our analysis @Nature.bsky.social
rdcu.be/ek1MH
May 9, 2025 at 12:08 AM
While #health systems across🌎 are designed around #acute illnesses, 86% of yrs lived w disability & 71% yrs of life lost are from #chronic diseases
Burden of chronic dz ⬆️ in higher income countries & w age
How to move needle? See our analysis @Nature.bsky.social
rdcu.be/ek1MH
Burden of chronic dz ⬆️ in higher income countries & w age
How to move needle? See our analysis @Nature.bsky.social
rdcu.be/ek1MH
Today, we voted to protect our #sovereignty, freedom, environment, economy, people,
We voted for knowledge, alliances, respect, strength, unity
We voted to care about those with less so that every kid has a chance to build #CanadaStrong
#ViveLeCanada #April2025
We voted for knowledge, alliances, respect, strength, unity
We voted to care about those with less so that every kid has a chance to build #CanadaStrong
#ViveLeCanada #April2025
April 29, 2025 at 3:34 AM
Today, we voted to protect our #sovereignty, freedom, environment, economy, people,
We voted for knowledge, alliances, respect, strength, unity
We voted to care about those with less so that every kid has a chance to build #CanadaStrong
#ViveLeCanada #April2025
We voted for knowledge, alliances, respect, strength, unity
We voted to care about those with less so that every kid has a chance to build #CanadaStrong
#ViveLeCanada #April2025
Canadians go to #polls today
Counting on us to elect a strategic, steady leader who will protect #Canada’s
- sovereignty
- environment
- economy
- education
- healthcare
- global alliances
Counting on us to reject politics of anger, fear, division
#TrueNorth #CanadaStrong
Counting on us to elect a strategic, steady leader who will protect #Canada’s
- sovereignty
- environment
- economy
- education
- healthcare
- global alliances
Counting on us to reject politics of anger, fear, division
#TrueNorth #CanadaStrong
April 28, 2025 at 11:06 AM
Canadians go to #polls today
Counting on us to elect a strategic, steady leader who will protect #Canada’s
- sovereignty
- environment
- economy
- education
- healthcare
- global alliances
Counting on us to reject politics of anger, fear, division
#TrueNorth #CanadaStrong
Counting on us to elect a strategic, steady leader who will protect #Canada’s
- sovereignty
- environment
- economy
- education
- healthcare
- global alliances
Counting on us to reject politics of anger, fear, division
#TrueNorth #CanadaStrong
Happy #AdministrativeProfessionalsDay, dear Robin
Thank you making magic happen in my professional life & in our program every day
Thank you for being a caring friend in the truest sense of the word
Thank you for being incredibly kind to our patients
I’m so #grateful for you
Thank you making magic happen in my professional life & in our program every day
Thank you for being a caring friend in the truest sense of the word
Thank you for being incredibly kind to our patients
I’m so #grateful for you
April 24, 2025 at 1:17 AM
Happy #AdministrativeProfessionalsDay, dear Robin
Thank you making magic happen in my professional life & in our program every day
Thank you for being a caring friend in the truest sense of the word
Thank you for being incredibly kind to our patients
I’m so #grateful for you
Thank you making magic happen in my professional life & in our program every day
Thank you for being a caring friend in the truest sense of the word
Thank you for being incredibly kind to our patients
I’m so #grateful for you
I voted on #EasterSunday for
- A builder of #bridges, not walls
- A strong #economy
- Strategic international #partnerships
- Environmental #sustainability
- Data-informed #policy
- #Education & #healthcare for all
- #Respect for all
Did you #vote?🇨🇦
#CanadaStrong
#CanadaElection2025
- A builder of #bridges, not walls
- A strong #economy
- Strategic international #partnerships
- Environmental #sustainability
- Data-informed #policy
- #Education & #healthcare for all
- #Respect for all
Did you #vote?🇨🇦
#CanadaStrong
#CanadaElection2025
April 21, 2025 at 6:12 PM
I voted on #EasterSunday for
- A builder of #bridges, not walls
- A strong #economy
- Strategic international #partnerships
- Environmental #sustainability
- Data-informed #policy
- #Education & #healthcare for all
- #Respect for all
Did you #vote?🇨🇦
#CanadaStrong
#CanadaElection2025
- A builder of #bridges, not walls
- A strong #economy
- Strategic international #partnerships
- Environmental #sustainability
- Data-informed #policy
- #Education & #healthcare for all
- #Respect for all
Did you #vote?🇨🇦
#CanadaStrong
#CanadaElection2025
April 20, 2025 at 12:05 PM
“Let everything you do
be done with love.”
- 1 Corinthians
Happy Easter from my home to yours!
#Easter2025
be done with love.”
- 1 Corinthians
Happy Easter from my home to yours!
#Easter2025
April 19, 2025 at 10:49 AM
“Let everything you do
be done with love.”
- 1 Corinthians
Happy Easter from my home to yours!
#Easter2025
be done with love.”
- 1 Corinthians
Happy Easter from my home to yours!
#Easter2025
Was honoured to talk to Dr Joseph Hill, EIC of Circulation @ahajournals.bsky.social about his career path, our era of medical disinformation, & power of effective scientific #communication.
Brilliant, accomplished, honest, humble, he’s among the best of the best!
#Publishing
tinyurl.com/2sdsuk7h
Brilliant, accomplished, honest, humble, he’s among the best of the best!
#Publishing
tinyurl.com/2sdsuk7h
April 18, 2025 at 11:16 AM
Was honoured to talk to Dr Joseph Hill, EIC of Circulation @ahajournals.bsky.social about his career path, our era of medical disinformation, & power of effective scientific #communication.
Brilliant, accomplished, honest, humble, he’s among the best of the best!
#Publishing
tinyurl.com/2sdsuk7h
Brilliant, accomplished, honest, humble, he’s among the best of the best!
#Publishing
tinyurl.com/2sdsuk7h
The #TarteAuChocolat was delicious, but the note was even sweeter!
I never take our privilege for granted.
#Cardiology #Medicine #Chocolate
I never take our privilege for granted.
#Cardiology #Medicine #Chocolate
April 17, 2025 at 2:28 PM
The #TarteAuChocolat was delicious, but the note was even sweeter!
I never take our privilege for granted.
#Cardiology #Medicine #Chocolate
I never take our privilege for granted.
#Cardiology #Medicine #Chocolate
New 2025 #CONSORT guidelines for #RCT #reporting standards
The 30 checklist items ensure transparent reporting, but adherence is suboptimal & only required by some journals
(onlinelibrary.wiley.com/doi/10.1002/ej…)
Essential for trialists + editorial/review teams!www.bmj.com/content/389/...23
The 30 checklist items ensure transparent reporting, but adherence is suboptimal & only required by some journals
(onlinelibrary.wiley.com/doi/10.1002/ej…)
Essential for trialists + editorial/review teams!www.bmj.com/content/389/...23
April 16, 2025 at 12:27 AM
New 2025 #CONSORT guidelines for #RCT #reporting standards
The 30 checklist items ensure transparent reporting, but adherence is suboptimal & only required by some journals
(onlinelibrary.wiley.com/doi/10.1002/ej…)
Essential for trialists + editorial/review teams!www.bmj.com/content/389/...23
The 30 checklist items ensure transparent reporting, but adherence is suboptimal & only required by some journals
(onlinelibrary.wiley.com/doi/10.1002/ej…)
Essential for trialists + editorial/review teams!www.bmj.com/content/389/...23
April 13, 2025 at 10:35 AM
#Nudges are behavioral interventions that influence decisions without restricting choices or giving incentives
This 2x2 factorial #RCT will evaluate effect of 🇩🇰 nationwide electronic letter nudges delivered to people with #CKD, their GPs, or both on #GDMT
www.sciencedirect.com/science/arti...
This 2x2 factorial #RCT will evaluate effect of 🇩🇰 nationwide electronic letter nudges delivered to people with #CKD, their GPs, or both on #GDMT
www.sciencedirect.com/science/arti...
April 13, 2025 at 12:11 AM
#Nudges are behavioral interventions that influence decisions without restricting choices or giving incentives
This 2x2 factorial #RCT will evaluate effect of 🇩🇰 nationwide electronic letter nudges delivered to people with #CKD, their GPs, or both on #GDMT
www.sciencedirect.com/science/arti...
This 2x2 factorial #RCT will evaluate effect of 🇩🇰 nationwide electronic letter nudges delivered to people with #CKD, their GPs, or both on #GDMT
www.sciencedirect.com/science/arti...
Is anyone aware of any #RCT that demonstrated the efficacy of any intervention in any CVD on the primary #endpoint of “days alive and out of the hospital”?
If so, please share.
(And what #breakfast are you having to fuel the clinical workday?)
#DAOH #TrialDesign
If so, please share.
(And what #breakfast are you having to fuel the clinical workday?)
#DAOH #TrialDesign
April 10, 2025 at 11:24 AM
Is anyone aware of any #RCT that demonstrated the efficacy of any intervention in any CVD on the primary #endpoint of “days alive and out of the hospital”?
If so, please share.
(And what #breakfast are you having to fuel the clinical workday?)
#DAOH #TrialDesign
If so, please share.
(And what #breakfast are you having to fuel the clinical workday?)
#DAOH #TrialDesign
📌E.g. of #Coanda effect: jet passing through an orifice that abuts a curved surface will deviate from ipath & adhere to surface
📌Due to entrainment of fluid from downstream chamber into jet, creating low P area around jet margin (towards which jet moves)
#EchoFirst #MR #Flail
📌Due to entrainment of fluid from downstream chamber into jet, creating low P area around jet margin (towards which jet moves)
#EchoFirst #MR #Flail
April 9, 2025 at 11:51 PM
📌E.g. of #Coanda effect: jet passing through an orifice that abuts a curved surface will deviate from ipath & adhere to surface
📌Due to entrainment of fluid from downstream chamber into jet, creating low P area around jet margin (towards which jet moves)
#EchoFirst #MR #Flail
📌Due to entrainment of fluid from downstream chamber into jet, creating low P area around jet margin (towards which jet moves)
#EchoFirst #MR #Flail
When you take a break from hospital clinical services to meet @vkittipibul who is visiting @PHRIresearch as part of @DCRIFellows exchange program..
April 9, 2025 at 1:59 PM
When you take a break from hospital clinical services to meet @vkittipibul who is visiting @PHRIresearch as part of @DCRIFellows exchange program..
Wonder what makes #healthcare systems successful?
Read this #GlobalRounds 📑 on #Denmark led by Tor Biering-Sorensen in #Circulation @AHAjournals.bsky.social
Economically just society
Universal healthcare
Strong primary care for every person
Enviable clinical & research infrastructure
#Cardiosky
Read this #GlobalRounds 📑 on #Denmark led by Tor Biering-Sorensen in #Circulation @AHAjournals.bsky.social
Economically just society
Universal healthcare
Strong primary care for every person
Enviable clinical & research infrastructure
#Cardiosky
April 9, 2025 at 10:26 AM
Wonder what makes #healthcare systems successful?
Read this #GlobalRounds 📑 on #Denmark led by Tor Biering-Sorensen in #Circulation @AHAjournals.bsky.social
Economically just society
Universal healthcare
Strong primary care for every person
Enviable clinical & research infrastructure
#Cardiosky
Read this #GlobalRounds 📑 on #Denmark led by Tor Biering-Sorensen in #Circulation @AHAjournals.bsky.social
Economically just society
Universal healthcare
Strong primary care for every person
Enviable clinical & research infrastructure
#Cardiosky