Houlston Lab, ICR
@houlstonlab-icr.bsky.social
We are the Cancer Genomics group at @icrlondon.bsky.social working to understand the genetic basis of cancer. GWAS, TWAS, pheWAS, MR, WGS, Hi-C, genetic epidemiology, functional annotation
https://houlston.group
https://houlston.group
Reposted by Houlston Lab, ICR
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
September 15, 2025 at 8:40 AM
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Ie: it's not us (Samtools team)! Be warned
Reposted by Houlston Lab, ICR
✅ Published in @natureportfolio.nature.com today, the paper describing the initial whole-genome sequencing analysis of 500,000 UK Biobank participants.
Read here: www.nature.com/articles/s41...
Read here: www.nature.com/articles/s41...
Whole-genome sequencing of 490,640 UK Biobank participants - Nature
A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation a...
www.nature.com
August 6, 2025 at 3:17 PM
✅ Published in @natureportfolio.nature.com today, the paper describing the initial whole-genome sequencing analysis of 500,000 UK Biobank participants.
Read here: www.nature.com/articles/s41...
Read here: www.nature.com/articles/s41...
An incredibly valuable tool that we use all the time! Thank you to everyone at @ucscgenomics.bsky.social that maintains it for us!
After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact
https://go.nature.com/40wPxkB
https://go.nature.com/40wPxkB
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
go.nature.com
June 30, 2025 at 2:11 PM
An incredibly valuable tool that we use all the time! Thank you to everyone at @ucscgenomics.bsky.social that maintains it for us!
Reposted by Houlston Lab, ICR
Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
June 25, 2025 at 2:29 PM
Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
Reposted by Houlston Lab, ICR
Textbooks: “Enhancers are just a bunch of TFBSs”
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
June 18, 2025 at 5:56 PM
Textbooks: “Enhancers are just a bunch of TFBSs”
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
It's not all work and no play in the Houlston Lab. We had our annual #Easter taste test! Returning to hot cross buns this year. We went a bit maverick and allowed some more ... unconventional varieties!
#hotcrossbuns #tastetests
📸: @jessicamayh.bsky.social
#hotcrossbuns #tastetests
📸: @jessicamayh.bsky.social
April 17, 2025 at 3:20 PM
It's not all work and no play in the Houlston Lab. We had our annual #Easter taste test! Returning to hot cross buns this year. We went a bit maverick and allowed some more ... unconventional varieties!
#hotcrossbuns #tastetests
📸: @jessicamayh.bsky.social
#hotcrossbuns #tastetests
📸: @jessicamayh.bsky.social
We are excited to announce our latest publication in #BloodCancerJournal of our Two-Sample MR analysis to investigate causal relationships between 446 immune cell traits and 6 B-cell malignancies
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy - Blood Cancer Journal
Blood Cancer Journal - Mendelian randomization of immune cell phenotypes to discover potential drug targets for B-cell malignancy
www.nature.com
April 16, 2025 at 11:52 AM
We are excited to announce our latest publication in #BloodCancerJournal of our Two-Sample MR analysis to investigate causal relationships between 446 immune cell traits and 6 B-cell malignancies
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
📄 www.nature.com/articles/s41...
#cancer #genetics #Bcell #bloodcancer #drugdiscovery #MR
Reposted by Houlston Lab, ICR
In response to a recent Guardian article about why approved researchers in China can access our data, we have provided some additional information for our participants, including how we follow Government guidance on who can use UK Biobank.
Please read here: ow.ly/yWsi50VAIIH
Please read here: ow.ly/yWsi50VAIIH
A message to our participants: why researchers in China can access our data
You may have questions about an article in The Guardian discussing why researchers in China are able to access UK Biobank. Read some additional information.
ow.ly
April 15, 2025 at 11:20 AM
In response to a recent Guardian article about why approved researchers in China can access our data, we have provided some additional information for our participants, including how we follow Government guidance on who can use UK Biobank.
Please read here: ow.ly/yWsi50VAIIH
Please read here: ow.ly/yWsi50VAIIH
Reposted by Houlston Lab, ICR
Today is #InternationalWomensDay 👏
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
March 8, 2025 at 10:26 AM
Today is #InternationalWomensDay 👏
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.
You inspire us every day 👩🔬👩💻👩💼
#IWD2025 #AccelerateAction
January 30, 2025 at 10:51 AM