Holly Arnold
@hollyarnold.bsky.social
Microbiome Scientist | Assistant Professor
Reposted by Holly Arnold
A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome
#immunosky #microsky #microbiome
A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology
This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...
www.nature.com
June 12, 2025 at 3:41 PM
A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome
#immunosky #microsky #microbiome
Reposted by Holly Arnold
*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 9, 2025 at 2:04 PM
*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪
Reposted by Holly Arnold
Fight the Empire.
June 9, 2025 at 7:09 PM
Fight the Empire.
Reposted by Holly Arnold
Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...
June 3, 2025 at 12:30 PM
Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...
Reposted by Holly Arnold
#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 4:15 PM
#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
Reposted by Holly Arnold
A Florida weatherman telling his viewers he can no longer be confident in his forecasts due to cuts to atmospheric science is the kind of resistance content I’m here for.
Kudos, Sir.🌦️
Kudos, Sir.🌦️
June 3, 2025 at 10:00 PM
A Florida weatherman telling his viewers he can no longer be confident in his forecasts due to cuts to atmospheric science is the kind of resistance content I’m here for.
Kudos, Sir.🌦️
Kudos, Sir.🌦️
Reposted by Holly Arnold
Viewpoint in JAMA details the consequences of the proposed cuts to NIH:
❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually
All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...
❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually
All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...
Cutting the NIH—The $8 Trillion Health Care Catastrophe
This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...
jamanetwork.com
May 30, 2025 at 1:18 PM
Viewpoint in JAMA details the consequences of the proposed cuts to NIH:
❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually
All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...
❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually
All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...
Reposted by Holly Arnold
How bad will it be? Catastrophic.
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
May 31, 2025 at 2:50 AM
Reposted by Holly Arnold
Very happy that our story on explosive telencephalon growth in killifish found its home in @biologists.bsky.social #BiologyOpen. Descriptive and simple, but gene expression in this brain is oh so beautiful. journals.biologists.com/bio/article/...
Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon
Summary: This study charts spatial patterns of growth of the African turquoise killifish telencephalon from hatching to adulthood, and identifies the progenitors and neurons present during this phase ...
journals.biologists.com
April 25, 2025 at 2:28 PM
Very happy that our story on explosive telencephalon growth in killifish found its home in @biologists.bsky.social #BiologyOpen. Descriptive and simple, but gene expression in this brain is oh so beautiful. journals.biologists.com/bio/article/...
Reposted by Holly Arnold
🗣️ #killifish researchers & facilities: The community (led by Dr. Beate Hoppe @leibnizfli.bsky.social) is conducting an anonymous survey on husbandry of the African turquoise killifish (Nothobranchius furzeri) in hopes to standardize care & refinement. 🔗 to help: survey.lamapoll.de/Global-Surve...
April 25, 2025 at 10:55 AM
🗣️ #killifish researchers & facilities: The community (led by Dr. Beate Hoppe @leibnizfli.bsky.social) is conducting an anonymous survey on husbandry of the African turquoise killifish (Nothobranchius furzeri) in hopes to standardize care & refinement. 🔗 to help: survey.lamapoll.de/Global-Surve...
Reposted by Holly Arnold
Today CLS objected to the proposed politicization of staff positions at US Science Agencies, particularly program managers whose expertise is critical to a strong and vibrant innovation ecosystem.
#ScheduleF
#ScheduleF
www.coalitionforlifesciences.org
May 28, 2025 at 8:28 PM
Today CLS objected to the proposed politicization of staff positions at US Science Agencies, particularly program managers whose expertise is critical to a strong and vibrant innovation ecosystem.
#ScheduleF
#ScheduleF
Reposted by Holly Arnold
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
April 28, 2025 at 5:20 PM
Deaths from heart disease down 75%, that’s NIH.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Deaths from stroke down 75%, that’s NIH.
HIV/AIDS no longer a death sentence, that’s NIH.
99% of FDA approved drugs in the last decade, that’s NIH.
Please show this video to anyone who doesn’t understand why the NIH is so important.
Reposted by Holly Arnold
Another step for microbiome research!🔬 New study introduces saMBA, a gut microbiome archive from South America. Understanding the full picture of gut microbiome biodiversity is crucial & saMBA is helping us get there!
@bvalderrama.bsky.social @jfcryan.bsky.social
www.biorxiv.org/content/10.1...
@bvalderrama.bsky.social @jfcryan.bsky.social
www.biorxiv.org/content/10.1...
The South American MicroBiome Archive (saMBA): Enriching the healthy microbiome concept by evaluating uniqueness and biodiversity of neglected populations
The composition and function of the human gut microbiome has been linked to multiple health outcomes across all world regions, often with region-specific associations. Unfortunately, the extent to whi...
www.biorxiv.org
April 21, 2025 at 11:57 AM
Another step for microbiome research!🔬 New study introduces saMBA, a gut microbiome archive from South America. Understanding the full picture of gut microbiome biodiversity is crucial & saMBA is helping us get there!
@bvalderrama.bsky.social @jfcryan.bsky.social
www.biorxiv.org/content/10.1...
@bvalderrama.bsky.social @jfcryan.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Holly Arnold
The gut microbiome and multiple sclerosis, using a discordant twin human-mouse transfer model
"Our results implicate two Lachnospiraceae members,
namely Eisenbergiella tayi and Lachnoclostridium, as likely
responsible for an increased incidence of disease."
www.pnas.org/doi/full/10....
"Our results implicate two Lachnospiraceae members,
namely Eisenbergiella tayi and Lachnoclostridium, as likely
responsible for an increased incidence of disease."
www.pnas.org/doi/full/10....
April 21, 2025 at 11:15 PM
The gut microbiome and multiple sclerosis, using a discordant twin human-mouse transfer model
"Our results implicate two Lachnospiraceae members,
namely Eisenbergiella tayi and Lachnoclostridium, as likely
responsible for an increased incidence of disease."
www.pnas.org/doi/full/10....
"Our results implicate two Lachnospiraceae members,
namely Eisenbergiella tayi and Lachnoclostridium, as likely
responsible for an increased incidence of disease."
www.pnas.org/doi/full/10....
Reposted by Holly Arnold
My talking points in recent interviews, please use as you see fit:
1.Every $1 in NIH funding returns ~$2.50 to the economy.
2.Every $1B in cuts from NIH extramural = 7500 lost employees, just in science.
3.These don't include priceless improvements in health.
1/x
1.Every $1 in NIH funding returns ~$2.50 to the economy.
2.Every $1B in cuts from NIH extramural = 7500 lost employees, just in science.
3.These don't include priceless improvements in health.
1/x
March 12, 2025 at 2:29 AM
My talking points in recent interviews, please use as you see fit:
1.Every $1 in NIH funding returns ~$2.50 to the economy.
2.Every $1B in cuts from NIH extramural = 7500 lost employees, just in science.
3.These don't include priceless improvements in health.
1/x
1.Every $1 in NIH funding returns ~$2.50 to the economy.
2.Every $1B in cuts from NIH extramural = 7500 lost employees, just in science.
3.These don't include priceless improvements in health.
1/x
Reposted by Holly Arnold
🧪
Here is the full time evolution of the R01 grant size distribution from 1998 to 2023 showing the effect of the modular cap and then the disappearance of this influence.
November 19, 2024 at 4:21 AM
🧪
Reposted by Holly Arnold
How diet shapes gut microbiota and affects brain function 🍽️🧠🌿 www.news-medical.net/news/2024082... #GutBrainAxis #Microbiota #Diet #Brain #Neuropsychiatry #Cognitive #Health #EmotionalWellness #BrainResearch #MicrobiomeScience #Food #MentalHealth
How diet shapes gut microbiota and affects brain function
Researchers discuss the diet-microbiota-gut-brain axis, which describes the role of both diet and gut microbiota composition on cognitive and emotional health.
www.news-medical.net
August 26, 2024 at 9:59 PM
How diet shapes gut microbiota and affects brain function 🍽️🧠🌿 www.news-medical.net/news/2024082... #GutBrainAxis #Microbiota #Diet #Brain #Neuropsychiatry #Cognitive #Health #EmotionalWellness #BrainResearch #MicrobiomeScience #Food #MentalHealth
🚀 Starting out as a new PI 🚀
It’s been an exciting (and humbling) journey stepping into my role as a new PI! Balancing research goals, teaching, and lab management has been both challenging and rewarding. 1/
#NewPI #ResearchLife #AcademicJourney #MicrobiomeScience
November 4, 2024 at 2:43 AM
🚀 Starting out as a new PI 🚀
It’s been an exciting (and humbling) journey stepping into my role as a new PI! Balancing research goals, teaching, and lab management has been both challenging and rewarding. 1/
#NewPI #ResearchLife #AcademicJourney #MicrobiomeScience
Reposted by Holly Arnold
Why deermice don’t get sick from Lyme disease. elifesciences.org/digests/9013...
Why deermice do not get sick from Lyme disease
Comparing the immune response of deer mice, mice and rats highlights a mechanism by which certain species can tolerate the bacteria responsible for Lyme disease.
elifesciences.org
January 10, 2024 at 12:20 PM
Why deermice don’t get sick from Lyme disease. elifesciences.org/digests/9013...