AbstractBackground. Internalized stigma impacts inflammatory bowel disease (IBD) patients’ wellbeing and has complex relationships with experiences of disc

Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory gene signatures. In parallel, our study identifies sex-specific immune and hormonal biomarkers that correlate with clinical symptoms, supporting the need for tailored therapeutic strategies, including consideration of hormone replacement therapy.

In this Expert Recommendation, Holowatyj et al. cover the current state of the field in appendiceal cancer, including the distinct challenges involved in studying this rare tumour type, and propose a conceptual research framework to facilitate discoveries that will advance knowledge of appendiceal..

NCCN Guidelines for Appendiceal Cancer: Defining a New Standard of Care 2025 / appendiceal cancer, cancer, Cancer Management, NCCN, NCCN guidelines, NCCN

Polyacylated anthocyanins are known for their enhanced stability and immunosuppressive properties. Although peonidin-3-O-(3,6-O-dimalonyl-β-D-glucosid…

Nature Reviews Gastroenterology & Hepatology, Published online: 05 November 2025; doi:10.1038/s41575-025-01134-zThe gut virome is a complex ecosystem and has a critical role in human health. This Review outlines gut virome composition and functional relevance, and its role in human health and disease. Methodological challenges in advancing our knowledge of the gut virome are also discussed.

npj Biofilms and Microbiomes - Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level

Traumatic brain injury (TBI) is a chronic and debilitating disease, associated with a high risk of psychiatric and neurodegenerative diseases. Despite significant advancements in improving outcomes, the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. Th …

Brain scans of former football players revealed subtle differences in brain grooves compared to men who never played contact sports, possibly marking early signs of chronic traumatic encephalopathy (C...

A new study shows that bacterial cell wall molecules, specifically peptidoglycan, are present in the brain and fluctuate with sleep cycles.

There are new findings out about the benefits of eating walnuts. Results from a UConn School of Medicine clinical trial on the cover of the April edition of the journal Cancer Prevention Research show...

Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2025; doi:10.1038/s41575-025-01132-1This Review explores the different types of sensory nerves involved in gut–brain communication, detailing the locations of these nerve endings in the gut and their mechanisms of activation. Insights and new information regarding spinal and vagal afferents alongside viscerofugal neurons are detailed.

Learn how new trial data show CT colonography offers similar colorectal cancer detection to biennial FIT.

Discover how a recent cohort study links medical imaging radiation to increased childhood haematologic cancer risk.