Hellen C. Greenblatt
@hellengreenblat.bsky.social
#Homeostasis is essential. Interests in #gut-#brain-#immune axis. #Microbiome. Balance and limit #inflammation → ↑ QOL.
In vivo, maternal Ig ↆ oral #rotavirus vaccine immunogenicity by ↑ vaccine clearance, thereby ↆ protection. Note: in mice, MatAb interference is mediated by milk-derived antibodies. In humans, transplacental versus breast milk antibodies likely depends on the vaccine platform. bit.ly/3L8thbU
October 14, 2025 at 6:05 PM
In vivo, maternal Ig ↆ oral #rotavirus vaccine immunogenicity by ↑ vaccine clearance, thereby ↆ protection. Note: in mice, MatAb interference is mediated by milk-derived antibodies. In humans, transplacental versus breast milk antibodies likely depends on the vaccine platform. bit.ly/3L8thbU
#Parkinson’s disease. 5/10 of PD brains evidence of human #pegivirus (HPgV) vs. 0/14 HPgV-. HPgV-brain+ patients with PD → ↑ neuropathology. Blood+ →↑ IGF-1 and ↆ pS65-ubiquitin, supporting disruption in #mitophagy in response to #HPgV. bit.ly/4mEAuOT [open access].
September 1, 2025 at 5:49 PM
#Parkinson’s disease. 5/10 of PD brains evidence of human #pegivirus (HPgV) vs. 0/14 HPgV-. HPgV-brain+ patients with PD → ↑ neuropathology. Blood+ →↑ IGF-1 and ↆ pS65-ubiquitin, supporting disruption in #mitophagy in response to #HPgV. bit.ly/4mEAuOT [open access].
#Mesenchymal stromal cells (MSCs) → mediate repair. #Obesity impairs MSC functionality → #inflammation. bit.ly/4mEqzZJ
August 22, 2025 at 4:51 PM
#Mesenchymal stromal cells (MSCs) → mediate repair. #Obesity impairs MSC functionality → #inflammation. bit.ly/4mEqzZJ
Pro-inflammatory signaling in #adipocytes essential for adipose expansion, remodeling, and tissue integrity. Counterintuitive? Suppression of adipocyte #inflammation →tumor-friendly microenvironment →mammary #cancer progression. bit.ly/4k7kKCc
June 18, 2025 at 8:45 PM
Pro-inflammatory signaling in #adipocytes essential for adipose expansion, remodeling, and tissue integrity. Counterintuitive? Suppression of adipocyte #inflammation →tumor-friendly microenvironment →mammary #cancer progression. bit.ly/4k7kKCc
#Circadian clock rhythm is driven by #mitochondria→ #inflammation.” … new therapies targeting inflammasomes could be more effective if administered at specific times of the day when macrophage activity peaks.” bit.ly/4j6mexh bit.ly/3BLB4Z2 [open access]
December 25, 2024 at 9:19 PM
#Circadian clock rhythm is driven by #mitochondria→ #inflammation.” … new therapies targeting inflammasomes could be more effective if administered at specific times of the day when macrophage activity peaks.” bit.ly/4j6mexh bit.ly/3BLB4Z2 [open access]
BALANCING ACT
“#Inflammation is both our body’s best natural defense and the underlying cause of many serious, chronic illnesses. How do you treat a dangerous condition that’s also a fundamental biological process?” bit.ly/41CuTRp [open access]
“#Inflammation is both our body’s best natural defense and the underlying cause of many serious, chronic illnesses. How do you treat a dangerous condition that’s also a fundamental biological process?” bit.ly/41CuTRp [open access]
December 17, 2024 at 2:01 AM
BALANCING ACT
“#Inflammation is both our body’s best natural defense and the underlying cause of many serious, chronic illnesses. How do you treat a dangerous condition that’s also a fundamental biological process?” bit.ly/41CuTRp [open access]
“#Inflammation is both our body’s best natural defense and the underlying cause of many serious, chronic illnesses. How do you treat a dangerous condition that’s also a fundamental biological process?” bit.ly/41CuTRp [open access]
November 27, 2024 at 5:05 PM