🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky
i-base.info/htb/50631
Full results from the STOMP study have now been presented. They show that tecovirimat didn’t help treat or reduce pain from mpox.
#CROI2025 #IDsky #HIVsky #Medsky #DRC #GlobalHealth #GlobalCrisis
i-base.info/htb/50631
Full results from the STOMP study have now been presented. They show that tecovirimat didn’t help treat or reduce pain from mpox.
#CROI2025 #IDsky #HIVsky #Medsky #DRC #GlobalHealth #GlobalCrisis
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?
academic.oup.com/ofid/advance...
Of course, oral antibiotics, if an option, would beat all IV options hands down!
#IDSky #ClinMicro #AMR
@jac-amr.bsky.social
academic.oup.com/jacamr/artic...
Of course, oral antibiotics, if an option, would beat all IV options hands down!
#IDSky #ClinMicro #AMR
@jac-amr.bsky.social
academic.oup.com/jacamr/artic...
tinyurl.com/4cvdy6h2
#LiverSky #IDSky #MedSky #HepSky
tinyurl.com/4cvdy6h2
#LiverSky #IDSky #MedSky #HepSky
tMPS performed much better than Sanger sequencing of amplicons using panfungal PCR primers
www.clinicalmicrobiologyandinfection.com/article/S119...
tMPS performed much better than Sanger sequencing of amplicons using panfungal PCR primers
www.clinicalmicrobiologyandinfection.com/article/S119...
@aabdolra.bsky.social et al
T indotineae (which is terbinafine resistant in 3/4 cases) has rapidly spread thru the UK, now comprising 38% of dermatophytes at the national reference lab
wwwnc.cdc.gov/eid/article/...
@aabdolra.bsky.social et al
T indotineae (which is terbinafine resistant in 3/4 cases) has rapidly spread thru the UK, now comprising 38% of dermatophytes at the national reference lab
wwwnc.cdc.gov/eid/article/...
- TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox
- Enrollment stopped in all study arms
- Strong safety profile
- Efficacy in severe cases not assessed
www.globenewswire.com/news-release...
- TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox
- Enrollment stopped in all study arms
- Strong safety profile
- Efficacy in severe cases not assessed
www.globenewswire.com/news-release...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
✅ "People living with HIV"
❌ "Infected people"
✅ "HIV acquisition"
❌ "Infection"
✅ "A person who has acquired HIV"
❌ "Spreading HIV"
🌐 Join us in using inclusive language on #WorldAIDSDay & every day: www.iasociety.org/language-mat...
✅ "People living with HIV"
❌ "Infected people"
✅ "HIV acquisition"
❌ "Infection"
✅ "A person who has acquired HIV"
❌ "Spreading HIV"
🌐 Join us in using inclusive language on #WorldAIDSDay & every day: www.iasociety.org/language-mat...
Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility
Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
No difference in infection rates between those who received and those who did not receive antibiotic #idsky #medsky
academic.oup.com/cid/advance-...
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
No difference in infection rates between those who received and those who did not receive antibiotic #idsky #medsky
academic.oup.com/cid/advance-...
🆕️✨️What makes nitrofurantoin robust against resistance evolution,in spite of prolonged & extensive usage against UTIs? #idsky #medsky #utisky
www.nature.com/articles/s44...
🆕️✨️What makes nitrofurantoin robust against resistance evolution,in spite of prolonged & extensive usage against UTIs? #idsky #medsky #utisky
www.nature.com/articles/s44...
74 hospitals in 7 countries
3,608 patients
A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky
www.nejm.org/doi/full/10....
74 hospitals in 7 countries
3,608 patients
A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky
www.nejm.org/doi/full/10....
www.acpjournals.org/doi/10.7326/...
www.acpjournals.org/doi/10.7326/...
Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.
Cefiderocol...we hardly knew ye...
Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky
academic.oup.com/jac/advance-...
Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.
Cefiderocol...we hardly knew ye...
Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky
academic.oup.com/jac/advance-...
#IDsky #microsky @drneilstone.bsky.social
www.journalofinfection.com/article/S016...
#IDsky #microsky @drneilstone.bsky.social
www.journalofinfection.com/article/S016...
Writing papers:
Cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox
Recruiting:
Adj clinda vs not (all)
Adj cefazolin vs not (MRSA)
Oral switch vs IV (all)
Cefazolin +/- Erta/Placebo (MSSA)
Dapto vs Vanco (MRSA)
Coming "soon":
Rifampin vs. none for PVIE (all)
Ref: Dr.Lee #idsky
Writing papers:
Cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox
Recruiting:
Adj clinda vs not (all)
Adj cefazolin vs not (MRSA)
Oral switch vs IV (all)
Cefazolin +/- Erta/Placebo (MSSA)
Dapto vs Vanco (MRSA)
Coming "soon":
Rifampin vs. none for PVIE (all)
Ref: Dr.Lee #idsky
Colin Sutherland says findings raise concerns of pattern of resistant #malaria parasites.🦟 #PublicHealth
www.lshtm.ac.uk/newsevents/n...
Colin Sutherland says findings raise concerns of pattern of resistant #malaria parasites.🦟 #PublicHealth
www.lshtm.ac.uk/newsevents/n...