Hector
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hector86.bsky.social
Hector
@hector86.bsky.social
Infectious diseases physician and clinical microbiologist | Senior clinical lecturer UWA | Brit based in Perth | small dogs and also larger dogs | #IDsky 🐶🏳️‍🌈🇦🇺🇬🇧🦠
Reposted by Hector
The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky
April 12, 2025 at 3:09 PM
Reposted by Hector
#Tecovirimat has no benefit against #mpox:

i-base.info/htb/50631

Full results from the STOMP study have now been presented. They show that tecovirimat didn’t help treat or reduce pain from mpox.

#CROI2025 #IDsky #HIVsky #Medsky #DRC #GlobalHealth #GlobalCrisis
March 26, 2025 at 9:03 AM
Reposted by Hector
#IDsky
Wow. Increased major cardiovascular event with abacavir compared to TDF and TAF up to 40-50%. Absolute numbers low but still.
Does this make ABC obsolete? Do we switch everyone off based on this if they have alternative options?

academic.oup.com/ofid/advance...
March 21, 2025 at 12:18 PM
Reposted by Hector
Self administration of OPAT is the winner in terms of environmental impact.

Of course, oral antibiotics, if an option, would beat all IV options hands down!

#IDSky #ClinMicro #AMR
@jac-amr.bsky.social

academic.oup.com/jacamr/artic...
March 15, 2025 at 8:05 AM
Reposted by Hector
DOR/ISL studies #CROI2025

I don’t understand why HBV vaccination AND confirmed protection wasn’t an inclusion criteria

2 unnecessary acute HBV cases

#IDsky #HIVsky
March 12, 2025 at 8:07 PM
Reposted by Hector
New research - Early antiviral treatment with tenofovir alafenamide to prevent serious clinical adverse events in adults with chronic hepatitis B and moderate or high viraemia (ATTENTION): interim results from a randomised controlled trial

tinyurl.com/4cvdy6h2

#LiverSky #IDSky #MedSky #HepSky
February 4, 2025 at 5:56 AM
Reposted by Hector
Detection of fungal pathogens by a histomolecular approach using targeted-massive parallel sequencing on formalin-fixed tissues: a retrospective study

tMPS performed much better than Sanger sequencing of amplicons using panfungal PCR primers

www.clinicalmicrobiologyandinfection.com/article/S119...
January 22, 2025 at 4:02 PM
Reposted by Hector
Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

@aabdolra.bsky.social et al

T indotineae (which is terbinafine resistant in 3/4 cases) has rapidly spread thru the UK, now comprising 38% of dermatophytes at the national reference lab

wwwnc.cdc.gov/eid/article/...
Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024
Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024
wwwnc.cdc.gov
December 26, 2024 at 3:59 PM
Reposted by Hector
STOMP Study Interim analysis:

- TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox
- Enrollment stopped in all study arms
- Strong safety profile
- Efficacy in severe cases not assessed
www.globenewswire.com/news-release...
Interim Results from STOMP Study of SIGA’s Tecovirimat in Treatment of Mpox Announced
Interim analysis shows that tecovirimat did not improve time to lesion resolution compared to placebo in adults with mild to moderate clade II mpoxStudy...
www.globenewswire.com
December 10, 2024 at 9:19 PM
Reposted by Hector
🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase: a systematic review and meta-analysis - Infec...
Background The best treatment for bloodstream infections (BSI) due to chromosomal AmpC (c-AmpC) producing Enterobacterales is not clearly defined. Objectives To describe the clinical and microbiologic...
link.springer.com
December 4, 2024 at 7:13 PM
Reposted by Hector
💬 Words have power! Choose them with care:

✅ "People living with HIV"
❌ "Infected people"

✅ "HIV acquisition"
❌ "Infection"

✅ "A person who has acquired HIV"
❌ "Spreading HIV"

🌐 Join us in using inclusive language on #WorldAIDSDay & every day: www.iasociety.org/language-mat...
December 1, 2024 at 3:16 PM
Reposted by Hector
academic.oup.com/jac/advance-...
Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility
A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK
AbstractObjectives. In England, group B streptococci (GBS; Streptococcus agalactiae) are considered universally susceptible to penicillin. Reports from Afr
academic.oup.com
November 24, 2024 at 1:48 PM
Reposted by Hector
🆕️⚡️⚡️ #CIDJournal
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
No difference in infection rates between those who received and those who did not receive antibiotic #idsky #medsky
academic.oup.com/cid/advance-...
Choosing Wisely: Effectiveness and Safety of Antibiotic Prophylaxis in Close Contacts of Invasive Group A Streptococci Infection
Abstract. Antibiotic prophylaxis is often recommended for close contacts of index cases of invasive Streptococcus pyogenes infections. Using MarketScan dat
academic.oup.com
November 26, 2024 at 2:19 PM
Reposted by Hector
Nitrofurantoin has shown exceptional durability against resistance over 70y of use
🆕️✨️What makes nitrofurantoin robust against resistance evolution,in spite of prolonged & extensive usage against UTIs? #idsky #medsky #utisky
www.nature.com/articles/s44...
Insights into durability against resistance from the antibiotic nitrofurantoin - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Insights into durability against resistance from the antibiotic nitrofurantoin
www.nature.com
November 25, 2024 at 6:28 PM
Reposted by Hector
🔥BALANCE RCT🔥
74 hospitals in 7 countries
3,608 patients
A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky
www.nejm.org/doi/full/10....
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
www.nejm.org
November 20, 2024 at 1:07 PM
Reposted by Hector
🆕️⚡️⚡️Oropouche Virus: A Rising Threat in the Western Hemisphere #idsky
www.acpjournals.org/doi/10.7326/...
Oropouche Virus: A Rising Threat in the Western Hemisphere | Annals of Internal Medicine
www.acpjournals.org
November 18, 2024 at 10:26 PM
Reposted by Hector
New paper from my colleagues at UCLH

Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria.

Cefiderocol...we hardly knew ye...

Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky

academic.oup.com/jac/advance-...
Resistance profiles of carbapenemase-producing Enterobacterales in a large centre in England: are we already losing cefiderocol?
AbstractBackground. Carbapenemase-producing Enterobacterales (CPE) pose difficult therapeutic challenges. We aimed to characterize antimicrobial resistance
academic.oup.com
November 18, 2024 at 10:34 AM
Reposted by Hector
🔥SNAP passed 3500🔥
Writing papers:
Cefazolin (MSSA) and penicillin (PSSA) vs (flu)clox
Recruiting:
Adj clinda vs not (all)
Adj cefazolin vs not (MRSA)
Oral switch vs IV (all)
Cefazolin +/- Erta/Placebo (MSSA)
Dapto vs Vanco (MRSA)
Coming "soon":
Rifampin vs. none for PVIE (all)
Ref: Dr.Lee #idsky
November 17, 2024 at 8:19 PM
Reposted by Hector
First evidence of resistance to lifesaving antimalarial drug in African children with severe malaria

Colin Sutherland says findings raise concerns of pattern of resistant #malaria parasites.🦟 #PublicHealth

www.lshtm.ac.uk/newsevents/n...
November 15, 2024 at 11:06 AM