Thank you, this could not have been done without using Rhea and Uniprot as the ground truth data. Thanks for curating and maintaining these foundational databases for biomedical research.

Thank you! It was truly a team effort. And was also inspired by some of the early works by John Dominy and Martha Stipanuk on CDO1 biology

Thank you Christian!!

lab at Dana-Farber, Nils @nilsburger.bsky.social at UTSW, Sumeet Khetarpal at UVA, Hilina, Katherine, Eric in the Fischer lab at Dana-Farber, and Ed Huttlin @edhuttlin.bsky.social and the Gygi lab @harvardcellbio.bsky.social.

Thanks to all authors and collaborators that pushed this work through the finish line. A special thanks goes to Junyi and Julius in my lab @stanfordbiochem.bsky.social and @stanford-cancer.bsky.social, Mika and Milan in the Valiant lab at Stanford Computer Science, Martha, Emma, Ed in the Chouchani

LRRC58 does so by serving as an E3 substrate adaptor that targets CDO1 for ubiquitylation and proteasomal degradation. We found that cysteine itself serves as a molecular signal to turn on and off LRRC58-mediated CDO1 degradation, and LRRC58 depletion stabilizes CDO1 to drive cysteine consumption.

hahaha yes maybe will announce something in the next month or so and post a hiring ad along with it- hoping to identify a postdoc candidate with expertise in mass spectrometry and data science to work on a few exciting projects!