Mike Hallett
@hallettmiket.bsky.social
Professor, Biochemistry, University of Western Ontario, London, Canada
Yesavage. Say what you want but definitely *overpaid*
October 30, 2025 at 3:45 AM
Yesavage. Say what you want but definitely *overpaid*
So is it @Rogers or is it @sportsnetpr.bsky.social or is it just me?!?! Every game night it is the same thing. Even when it works, it barely works. go #jays (until the 7th inning when it all just shuts down)
October 29, 2025 at 3:24 AM
So is it @Rogers or is it @sportsnetpr.bsky.social or is it just me?!?! Every game night it is the same thing. Even when it works, it barely works. go #jays (until the 7th inning when it all just shuts down)
Reposted by Mike Hallett
This life on planet earth isn’t the end. The consciousness survives. We are part of Mother Nature.
You get to choose the difference that you make.
#Pinks
You get to choose the difference that you make.
#Pinks
October 9, 2025 at 2:09 PM
This life on planet earth isn’t the end. The consciousness survives. We are part of Mother Nature.
You get to choose the difference that you make.
#Pinks
You get to choose the difference that you make.
#Pinks
ICE really missed an opportunity to make a difference last night in the Bronx. #gobluejays
October 9, 2025 at 11:32 AM
ICE really missed an opportunity to make a difference last night in the Bronx. #gobluejays
Reposted by Mike Hallett
Reposted by Mike Hallett
An article I wrote about this topic a few years ago:
worksinprogress.co/issue/real-p...
worksinprogress.co/issue/real-p...
Real peer review has never been tried - Works in Progress Magazine
Outdated forms of peer review create bottlenecks that slow science. But in a world where research can now circulate rapidly on the Internet, we need to develop new ways to do science in public.
worksinprogress.co
August 17, 2025 at 9:23 AM
An article I wrote about this topic a few years ago:
worksinprogress.co/issue/real-p...
worksinprogress.co/issue/real-p...
The DNA of pure DCIS. We look at prognosis (invasive & in situ local recurrence) & benefit to radiotherapy in a unique cohort of Ontarians. A manuscript with my long term collaborators Eileen Rakovitch (Sunnybrook) & @vdumeaux.bsky.social breast-cancer-research.biomedcentral.com/articles/10....
Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy - Breast Cancer Research
Background Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease ...
breast-cancer-research.biomedcentral.com
July 8, 2025 at 2:28 PM
The DNA of pure DCIS. We look at prognosis (invasive & in situ local recurrence) & benefit to radiotherapy in a unique cohort of Ontarians. A manuscript with my long term collaborators Eileen Rakovitch (Sunnybrook) & @vdumeaux.bsky.social breast-cancer-research.biomedcentral.com/articles/10....
The Oilers did extremely well to keep it as close as they did against a far better team.
June 18, 2025 at 12:07 PM
The Oilers did extremely well to keep it as close as they did against a far better team.
I have to say, I might have had difficult stopping McDavid even in my prime goaltending days.
June 7, 2025 at 2:55 PM
I have to say, I might have had difficult stopping McDavid even in my prime goaltending days.
Is it my imagination or is @wired.com the only news source from the USA now willing to report on the regime? I hope they keep it up.
June 5, 2025 at 8:16 PM
Is it my imagination or is @wired.com the only news source from the USA now willing to report on the regime? I hope they keep it up.
Reposted by Mike Hallett
10 courses to get you started with bioinformatics 🧵 Bookmark!
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
harvardx
rafalab.github.io
May 18, 2025 at 1:15 PM
10 courses to get you started with bioinformatics 🧵 Bookmark!
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
1/ rafalab.dfci.harvard.edu/pages/harva... by the almighty Rafa
Does the ICD-11 offer a diagnosis for a type of severe recurrent - but entirely foreseeable - post-traumatic stress disorder with onset at this time of every year? Asking for a friend here in southern Ontario.
May 15, 2025 at 11:58 AM
Does the ICD-11 offer a diagnosis for a type of severe recurrent - but entirely foreseeable - post-traumatic stress disorder with onset at this time of every year? Asking for a friend here in southern Ontario.
When I become rich, I will create my own hockey channel where commentators are forced to provide inferential statistics (CI, p-value, ACC, *anything*) for each proposed prognostic indicator. There will be clinical trials: random forced shavings, etc ... HNIC et al. have given stats a bad name.
May 9, 2025 at 7:21 PM
When I become rich, I will create my own hockey channel where commentators are forced to provide inferential statistics (CI, p-value, ACC, *anything*) for each proposed prognostic indicator. There will be clinical trials: random forced shavings, etc ... HNIC et al. have given stats a bad name.
🇨🇦 🏳️🌈 🤖📈🧬💻 🏳️⚧️ 🇨🇦
Tomorrow - Thursday April 17th 1pm - Open house for students with backgrounds in math, stats and computation to explore graduate work in the life & biomedical sciences @ Western University (Canada). Zoom or in person. western-bioinfo.github.io/events/open-... @westernu.bsky.social
Tomorrow - Thursday April 17th 1pm - Open house for students with backgrounds in math, stats and computation to explore graduate work in the life & biomedical sciences @ Western University (Canada). Zoom or in person. western-bioinfo.github.io/events/open-... @westernu.bsky.social
Open House | Medical Bioinformatics @Western
western-bioinfo.github.io
April 16, 2025 at 1:05 PM
🇨🇦 🏳️🌈 🤖📈🧬💻 🏳️⚧️ 🇨🇦
Tomorrow - Thursday April 17th 1pm - Open house for students with backgrounds in math, stats and computation to explore graduate work in the life & biomedical sciences @ Western University (Canada). Zoom or in person. western-bioinfo.github.io/events/open-... @westernu.bsky.social
Tomorrow - Thursday April 17th 1pm - Open house for students with backgrounds in math, stats and computation to explore graduate work in the life & biomedical sciences @ Western University (Canada). Zoom or in person. western-bioinfo.github.io/events/open-... @westernu.bsky.social
🇨🇦 🏳️🌈 🤖📈🧬💻 🏳️⚧️ 🇨🇦
Do you have a background in math, stats or computation & considering grad studies in the life science & biomedicine? Western University will hold an Open House with talks from researchers who use/develop quantitative methods in their research.
western-bioinfo.github.io/events/open-...
Do you have a background in math, stats or computation & considering grad studies in the life science & biomedicine? Western University will hold an Open House with talks from researchers who use/develop quantitative methods in their research.
western-bioinfo.github.io/events/open-...
Open House | Medical Bioinformatics @Western
western-bioinfo.github.io
March 28, 2025 at 6:06 PM
🇨🇦 🏳️🌈 🤖📈🧬💻 🏳️⚧️ 🇨🇦
Do you have a background in math, stats or computation & considering grad studies in the life science & biomedicine? Western University will hold an Open House with talks from researchers who use/develop quantitative methods in their research.
western-bioinfo.github.io/events/open-...
Do you have a background in math, stats or computation & considering grad studies in the life science & biomedicine? Western University will hold an Open House with talks from researchers who use/develop quantitative methods in their research.
western-bioinfo.github.io/events/open-...
I wish Canada would do the same.
Lessons here for Canada:
From sewage and scum to swimming in ‘blue gold’: how Switzerland transformed its rivers
www.theguardian.com/environment/...
From sewage and scum to swimming in ‘blue gold’: how Switzerland transformed its rivers
www.theguardian.com/environment/...
From sewage and scum to swimming in ‘blue gold’: how Switzerland transformed its rivers
In the 1960s, the Swiss had some of the dirtiest water in Europe. Now, their cities boast pristine rivers and lakes – and other countries are looking to follow their lead
www.theguardian.com
March 17, 2025 at 12:32 PM
I wish Canada would do the same.
Another nice collaboration with Sunnybrook and @vdumeaux.bsky.social
🧵 1/11 Excited to share our latest work on ductal carcinoma in situ (DCIS) genomics! We performed comprehensive genomic analysis of pure DCIS to better understand disease prognosis and treatment response. medrxiv.org/cgi/content/... #BreastCancer #DCIS #Cancer #Genomics #PrecisionMedicine
medrxiv.org
March 6, 2025 at 4:52 PM
Another nice collaboration with Sunnybrook and @vdumeaux.bsky.social
Reposted by Mike Hallett
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
Our new manuscript covering a new FFPE-based RNA-seq methodology. Led by John Mucaki and with our collaborators Vanessa Dumeaux at Western and Eileen Rakovitch at Sunnybrook. www.biorxiv.org/content/10.1...
Generative and integrative modeling for transcriptomics with formalin fixed paraffin embedded material
Formalin-fixed paraffin embedded (FFPE) samples are challenging to profile using existing high-throughput sequencing technologies, including RNA-seq. This difficulty primarily arises from the degradat...
www.biorxiv.org
February 28, 2025 at 11:42 PM
Our new manuscript covering a new FFPE-based RNA-seq methodology. Led by John Mucaki and with our collaborators Vanessa Dumeaux at Western and Eileen Rakovitch at Sunnybrook. www.biorxiv.org/content/10.1...
Reposted by Mike Hallett
Vote Ford Out
February 22, 2025 at 5:11 AM
Vote Ford Out
I even like Marchand.
February 21, 2025 at 5:18 AM
I even like Marchand.
Reposted by Mike Hallett
It never ceases to amaze me how researchers are still making breakthroughs with AIMS, a method we published 10 years ago with @hallettmiket.bsky.social . Now, AIMS is proving instrumental in revealing BC subtype switching before and after neoadjuvant treatment. tinyurl.com/bdday25t
Dynamics of molecular heterogeneity in high-risk luminal breast cancer—From intrinsic to adaptive subtyping
Denkert et al. evaluate adaptation of luminal high-risk breast cancer to neoadjuvant
therapy in longitudinal biopsies from Penelope-B trial and identify five adaptive
subtypes (AC1-5) by comparing pre...
tinyurl.com
February 14, 2025 at 3:29 PM
It never ceases to amaze me how researchers are still making breakthroughs with AIMS, a method we published 10 years ago with @hallettmiket.bsky.social . Now, AIMS is proving instrumental in revealing BC subtype switching before and after neoadjuvant treatment. tinyurl.com/bdday25t
Reposted by Mike Hallett
The Department of Pathology and Laboratory Medicine at the Schulich School of Medicine & Dentistry, Western University, is seeking applications for a full-time, tenure-track faculty position in Cancer Immunology and Therapeutics. PLEASE REPOST ! www.nature.com/naturecareer...
Full-time, Probationary (Tenure-Track) Faculty Position in Cancer Immunology and Therapeutics - London, Ontario (CA) job with Dr. David Driman, Chair/Department Head | 12834957
Full-time, Probationary (Tenure-Track) Faculty Position in Cancer Immunology and Therapeutics.
www.nature.com
February 6, 2025 at 6:47 PM
The Department of Pathology and Laboratory Medicine at the Schulich School of Medicine & Dentistry, Western University, is seeking applications for a full-time, tenure-track faculty position in Cancer Immunology and Therapeutics. PLEASE REPOST ! www.nature.com/naturecareer...
So the meth head that lives in the apartment below me just told me that he wouldn't break into my apartment if I could show that I was more serious about controlling the flow of meth into the building. It's best in these kinds of interactions to just nod your head yes and quietly walk away.
February 3, 2025 at 10:07 PM
So the meth head that lives in the apartment below me just told me that he wouldn't break into my apartment if I could show that I was more serious about controlling the flow of meth into the building. It's best in these kinds of interactions to just nod your head yes and quietly walk away.