Vineet Gupta
@guptavi.bsky.social
Reposted by Vineet Gupta
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
Integrins play a critical role in signaling events that regulate cell adhesion, migration, and proliferation, processes that, when dysregulated, contribute to cancer progression. Recently, innovati...
www.tandfonline.com
November 9, 2025 at 12:36 PM
Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Reposted by Vineet Gupta
I lost so many uncles/grand uncles to early AM heart attacks that my family used to dread early morning phone calls. Always wondered if there was a connection. Amazing finding 👇🏽
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability
www.sciencedirect.com
November 9, 2025 at 1:59 PM
I lost so many uncles/grand uncles to early AM heart attacks that my family used to dread early morning phone calls. Always wondered if there was a connection. Amazing finding 👇🏽
Reposted by Vineet Gupta
sjobs.brassring.com/TGnewUI/Sear... Come be @thesampsonlab.bsky.social Social Media & Community Outreach Coordinator. I am VERY interested in applicants bilingual in Spanish. We're growing by leaps and bounds & there are lots of opportunities to bring your own ideas. Please repost
Social Media Coordinator - Sampson Lab - Boston Childrens Hospital - Job Details
Job Details: The Sampson Lab for Kidney Genomics at Boston Children’s Hospital/Harvard Medical School is dedicated to uncov
sjobs.brassring.com
March 19, 2025 at 1:18 PM
sjobs.brassring.com/TGnewUI/Sear... Come be @thesampsonlab.bsky.social Social Media & Community Outreach Coordinator. I am VERY interested in applicants bilingual in Spanish. We're growing by leaps and bounds & there are lots of opportunities to bring your own ideas. Please repost
Interesting indeed to see ITGAM/CD11b (and ITGAL) associations with brain aging. I wonder if the association is via indirect increases in myeloid pro-inflammatory signaling and whether CD11b allosteric agonists could ameliorate that. 🤔
Interesting. Includes two leukocyte integrin subunits.
Researchers studying #brain #aging took advantage of AI to analyze brain scans from nearly 39,000 people from the UK Biobank database 🧪🧠
They identified 64 genes linked to aging, and 13 potential drugs - including rapamycin - that may help slow brain decline..
www.nature.com/articles/d41...
They identified 64 genes linked to aging, and 13 potential drugs - including rapamycin - that may help slow brain decline..
www.nature.com/articles/d41...
March 15, 2025 at 3:23 AM
Interesting indeed to see ITGAM/CD11b (and ITGAL) associations with brain aging. I wonder if the association is via indirect increases in myeloid pro-inflammatory signaling and whether CD11b allosteric agonists could ameliorate that. 🤔