Guido Barzaghi
@guidobarzaghi.bsky.social
NYU postdoc with Tsirigos and Aifantis labs.
Former EMBL Heidelberg PhD with Krebs and Zaugg labs.
Former EMBL Heidelberg PhD with Krebs and Zaugg labs.
Pinned
Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to perturbations of TF binding at the single molecule level bit.ly/3XQMFxN. I'm incredibly thankful to my PhD mentors @arnaudkr.bsky.social and Judith Zaugg for these super productive years!!
Reposted by Guido Barzaghi
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
May 16, 2025 at 10:05 AM
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
Reposted by Guido Barzaghi
5/2025 Issue ➡️ www.embopress.org/toc/17444292...
tissue-specific huntingtin interactomes, gene product diversity evolution
Cover: mammalian promoters characterised by low RNA pol II occupancy and high turnover @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social
tissue-specific huntingtin interactomes, gene product diversity evolution
Cover: mammalian promoters characterised by low RNA pol II occupancy and high turnover @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social
May 8, 2025 at 3:15 PM
5/2025 Issue ➡️ www.embopress.org/toc/17444292...
tissue-specific huntingtin interactomes, gene product diversity evolution
Cover: mammalian promoters characterised by low RNA pol II occupancy and high turnover @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social
tissue-specific huntingtin interactomes, gene product diversity evolution
Cover: mammalian promoters characterised by low RNA pol II occupancy and high turnover @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social
Don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.
April 8, 2025 at 3:52 PM
Don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.
Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to perturbations of TF binding at the single molecule level bit.ly/3XQMFxN. I'm incredibly thankful to my PhD mentors @arnaudkr.bsky.social and Judith Zaugg for these super productive years!!
April 8, 2025 at 3:41 PM
Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to perturbations of TF binding at the single molecule level bit.ly/3XQMFxN. I'm incredibly thankful to my PhD mentors @arnaudkr.bsky.social and Judith Zaugg for these super productive years!!
Reposted by Guido Barzaghi
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
April 2, 2025 at 8:47 AM
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...