Guillaume Andrey
@guandrey.bsky.social
Associate Professor / enhancers - 3D genome - morphogenesis
Website: https://www.unige.ch/medecine/gede/en/research-groups/999andrey
Website: https://www.unige.ch/medecine/gede/en/research-groups/999andrey
Thanks Alexis, I am very honoured.
August 29, 2025 at 7:48 PM
Thanks Alexis, I am very honoured.
Thank you very much!
July 10, 2025 at 10:31 AM
Thank you very much!
More details, and much more data, in the manuscript: www.nature.com/articles/s41...
Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications
Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...
www.nature.com
July 9, 2025 at 12:27 PM
More details, and much more data, in the manuscript: www.nature.com/articles/s41...
As Pitx1 and Pen interact in transcriptionally active cells, we investigated the link between transcription and enhancer-promoter (E-P) contacts. Activating Pitx1 transcription in forelimbs does not enhance Pitx1-Pen interactions, showing that transcription does not drive E-P contact in this context
July 9, 2025 at 12:24 PM
As Pitx1 and Pen interact in transcriptionally active cells, we investigated the link between transcription and enhancer-promoter (E-P) contacts. Activating Pitx1 transcription in forelimbs does not enhance Pitx1-Pen interactions, showing that transcription does not drive E-P contact in this context
The main finding of the paper is that the closer we reposition Pen to Pitx1, the more forelimb cells will start expressing Pitx1, and the more severe the phenotypic outcome will be.
July 9, 2025 at 12:12 PM
The main finding of the paper is that the closer we reposition Pen to Pitx1, the more forelimb cells will start expressing Pitx1, and the more severe the phenotypic outcome will be.
Pitx1 is normally confined to hindlimbs for leg development. In 2018 we showed that Pitx1's ectopic activation in the forelimb, via access to its Pen enhancer, triggers Liebenberg Syndrome, leading to arm malformations. www.nature.com/articles/s41...
July 9, 2025 at 12:05 PM
Pitx1 is normally confined to hindlimbs for leg development. In 2018 we showed that Pitx1's ectopic activation in the forelimb, via access to its Pen enhancer, triggers Liebenberg Syndrome, leading to arm malformations. www.nature.com/articles/s41...
Good point, intuitively I italicize but, looking at several papers, not sure there is a consensus.
June 20, 2025 at 6:47 PM
Good point, intuitively I italicize but, looking at several papers, not sure there is a consensus.