Rui Guan
@guan06rui.bsky.social
Computational microbiologist, research scientist at Hildebrand lab, Quadram Institute @quadraminstitute.bsky.social, Norwich, UK
Reposted by Rui Guan
More immune cells should mean better outcomes.
Yet in kidney cancer, glioma, uveal melanoma - it doesn’t.
We think tissue metabolism is the missing variable.
Immunometabolic gatekeeping - preprint out now 🔗
arxiv.org/abs/2511.20883
Yet in kidney cancer, glioma, uveal melanoma - it doesn’t.
We think tissue metabolism is the missing variable.
Immunometabolic gatekeeping - preprint out now 🔗
arxiv.org/abs/2511.20883
November 27, 2025 at 9:43 AM
More immune cells should mean better outcomes.
Yet in kidney cancer, glioma, uveal melanoma - it doesn’t.
We think tissue metabolism is the missing variable.
Immunometabolic gatekeeping - preprint out now 🔗
arxiv.org/abs/2511.20883
Yet in kidney cancer, glioma, uveal melanoma - it doesn’t.
We think tissue metabolism is the missing variable.
Immunometabolic gatekeeping - preprint out now 🔗
arxiv.org/abs/2511.20883
Reposted by Rui Guan
"These findings reinforce the urgent need to understand how drugs and other xenobiotics affect the gut microbiome."
💬 Our Director, Professor @dfigeys.bsky.social
💬 Our Director, Professor @dfigeys.bsky.social
Prebiotics reverse effects of anti-depressants on the gut microbiome - Quadram Institute
Scientists from the University of Ottawa and Beijing Institute of Lifeomics found that SSRIs, SNRIs and Tricyclic Antidepressants, commonly prescribed anti-depressants that target the…
buff.ly
November 26, 2025 at 10:01 AM
"These findings reinforce the urgent need to understand how drugs and other xenobiotics affect the gut microbiome."
💬 Our Director, Professor @dfigeys.bsky.social
💬 Our Director, Professor @dfigeys.bsky.social
Reposted by Rui Guan
An exciting opportunity to join my group @quadraminstitute.bsky.social to contribute to the development of our work on #microbiome#food interactions using cutting edge anaerobic fermentation models
🆕 Vacancy! We're looking for a Research Scientist to explore the impact of novel carbohydrate containing foods on the gut microbiome and on health.
💷 £37,500 to £45,350
🗓️ Apply by 30 November 2025
➡️ buff.ly/CKyGwgD
💷 £37,500 to £45,350
🗓️ Apply by 30 November 2025
➡️ buff.ly/CKyGwgD
November 6, 2025 at 11:32 AM
An exciting opportunity to join my group @quadraminstitute.bsky.social to contribute to the development of our work on #microbiome#food interactions using cutting edge anaerobic fermentation models
Reposted by Rui Guan
🎓 #PhDPosition !
🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social
📅Apply by 2 December
➡️ buff.ly/Pf6wmqO
🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social
📅Apply by 2 December
➡️ buff.ly/Pf6wmqO
November 4, 2025 at 8:45 AM
🎓 #PhDPosition !
🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social
📅Apply by 2 December
➡️ buff.ly/Pf6wmqO
🍔 Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome with Dr Falk Hildebrand @bioinf.bsky.social
📅Apply by 2 December
➡️ buff.ly/Pf6wmqO
Reposted by Rui Guan
New online! From clonality to complexity: a journey through microbial ecology and evolution
From clonality to complexity: a journey through microbial ecology and evolution
Nature Reviews Genetics, Published online: 30 October 2025; doi:10.1038/s41576-025-00910-6Jaime Martinez-Urtaza reflects on two papers by Smith et al., who found that bacteria exist along a continuum from clonal to recombining populations, and introduced the concept of an ‘epidemic’ microbial population structure.
www.nature.com
October 30, 2025 at 2:28 PM
New online! From clonality to complexity: a journey through microbial ecology and evolution
Reposted by Rui Guan
🆕We’re looking for a motivated candidate to explore the evolution of the gut microbiome in patients with Inflammatory Bowel Disease, working on cutting-edge metagenomics with clinical translation 🧬
🗓️ Apply by 6 January 2026
➡️ buff.ly/dFWnLv7
@bioinf.bsky.social
🗓️ Apply by 6 January 2026
➡️ buff.ly/dFWnLv7
@bioinf.bsky.social
October 27, 2025 at 3:30 PM
🆕We’re looking for a motivated candidate to explore the evolution of the gut microbiome in patients with Inflammatory Bowel Disease, working on cutting-edge metagenomics with clinical translation 🧬
🗓️ Apply by 6 January 2026
➡️ buff.ly/dFWnLv7
@bioinf.bsky.social
🗓️ Apply by 6 January 2026
➡️ buff.ly/dFWnLv7
@bioinf.bsky.social
Reposted by Rui Guan
There was great energy in #Southampton for our recent launch event 🌟
Want to catch up on the highlights from an exciting day?
Check out our new event report 👇
www.giba-uk.org/highlights
Want to catch up on the highlights from an exciting day?
Check out our new event report 👇
www.giba-uk.org/highlights
October 6, 2025 at 2:25 PM
There was great energy in #Southampton for our recent launch event 🌟
Want to catch up on the highlights from an exciting day?
Check out our new event report 👇
www.giba-uk.org/highlights
Want to catch up on the highlights from an exciting day?
Check out our new event report 👇
www.giba-uk.org/highlights
Reposted by Rui Guan
🚀 AIBIO-UK x L2D Training Scholarships
25 fully funded spots for biosciences researchers to learn:
🔹 Python
🔹 Data handling
🔹 ML & AI
🗓️ Apply by 21 Oct: forms.office.com/e/rVf0Q2H9a5
🔗 Info: aibio.ac.uk/opportunitie...
#AIBIOUK #AIinBiosciences #L2D #Scholarships
25 fully funded spots for biosciences researchers to learn:
🔹 Python
🔹 Data handling
🔹 ML & AI
🗓️ Apply by 21 Oct: forms.office.com/e/rVf0Q2H9a5
🔗 Info: aibio.ac.uk/opportunitie...
#AIBIOUK #AIinBiosciences #L2D #Scholarships
Microsoft Forms
forms.office.com
October 8, 2025 at 12:45 PM
🚀 AIBIO-UK x L2D Training Scholarships
25 fully funded spots for biosciences researchers to learn:
🔹 Python
🔹 Data handling
🔹 ML & AI
🗓️ Apply by 21 Oct: forms.office.com/e/rVf0Q2H9a5
🔗 Info: aibio.ac.uk/opportunitie...
#AIBIOUK #AIinBiosciences #L2D #Scholarships
25 fully funded spots for biosciences researchers to learn:
🔹 Python
🔹 Data handling
🔹 ML & AI
🗓️ Apply by 21 Oct: forms.office.com/e/rVf0Q2H9a5
🔗 Info: aibio.ac.uk/opportunitie...
#AIBIOUK #AIinBiosciences #L2D #Scholarships
Reposted by Rui Guan
TIRIS Postdoc fellowship call will soon be open in Toulouse! If you're interested in plant microbiota, or plant-plant interactions or experimental evolution, the ECOGEN team at the @lipme-toulouse.bsky.social would be happy to support and help with your application!
AToUT – TIRIS – Toulouse's Science In and For Society
tiris.univ-toulouse.fr
October 3, 2025 at 12:58 PM
TIRIS Postdoc fellowship call will soon be open in Toulouse! If you're interested in plant microbiota, or plant-plant interactions or experimental evolution, the ECOGEN team at the @lipme-toulouse.bsky.social would be happy to support and help with your application!
Reposted by Rui Guan
Exciting to see this launch today! This research is an excellent example of using plant science to improve human health, and highlights the value of BBSRC’s long-term investment in plant and nutritional science🍅🔬
Game changer for human health and science: and it’s happening right here in South Norfolk. 🌱🔬 1/4
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Norwich trial uses tomatoes to test gene-edited food on humans
Seventy-six people with low vitamin D levels are being recruited to take part in the study.
www.bbc.co.uk
September 23, 2025 at 12:17 PM
Exciting to see this launch today! This research is an excellent example of using plant science to improve human health, and highlights the value of BBSRC’s long-term investment in plant and nutritional science🍅🔬
Reposted by Rui Guan
Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦
Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential
Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential
Bifido adaptations across hosts
@halllab.bsky.social survey insects, reptiles, birds & mammals to uncover how Bifidobacterium adapts to hosts. Bifidobacterium & host exhibit strong co-phylogenetic associations, driven by vertical transmission & dietary selection
www.cell.com/cell-host-mi...
@halllab.bsky.social survey insects, reptiles, birds & mammals to uncover how Bifidobacterium adapts to hosts. Bifidobacterium & host exhibit strong co-phylogenetic associations, driven by vertical transmission & dietary selection
www.cell.com/cell-host-mi...
Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts
Bifidobacterium are beneficial members of the microbiota across animal hosts. Kujawska
et al. demonstrate that bifidobacteria have likely co-evolved more closely with mammals,
particularly primates, a...
www.cell.com
September 11, 2025 at 2:49 PM
Excited to share our @cp-cellhostmicrobe.bsky.social led by Magda showing how Bif has co-evolved with different animal hosts 🐒🐭🐷🐦
Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential
Key takeaways:
🔹 Host ancestry + diet shape Bif evolution
🔹 Mammals enriched for carb-busting enzymes
🔹 Untapped diversity in non-human hosts = new probiotic potential
Reposted by Rui Guan
🚨 New pre-print from the lab! We performed a large-scale meta-analysis of the uncultured gut #microbiome in >10,000 metagenomes enabling us to identify a new candidate biomarker of health. www.biorxiv.org/content/10.1...
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a new candidate biomarker of health
The human gut microbiome plays an important biological role in host health, yet over 60% of gut species remain uncultured and hence inaccessible to experimental manipulation. Here we analysed 11,115 h...
www.biorxiv.org
September 10, 2025 at 11:44 AM
🚨 New pre-print from the lab! We performed a large-scale meta-analysis of the uncultured gut #microbiome in >10,000 metagenomes enabling us to identify a new candidate biomarker of health. www.biorxiv.org/content/10.1...
Reposted by Rui Guan
🆕 Vacancy! We’re looking for a #Metagenomics Research Scientist to join the Laboratory of Dr Falk Hildebrand @bioinf.bsky.social to study diet impact on the gastrointestinal microbiome.
💷 £37,500 - £42,000
🗓️ Apply by 30 September 2025
➡️ buff.ly/uwqGQQm
💷 £37,500 - £42,000
🗓️ Apply by 30 September 2025
➡️ buff.ly/uwqGQQm
September 3, 2025 at 11:00 AM
🆕 Vacancy! We’re looking for a #Metagenomics Research Scientist to join the Laboratory of Dr Falk Hildebrand @bioinf.bsky.social to study diet impact on the gastrointestinal microbiome.
💷 £37,500 - £42,000
🗓️ Apply by 30 September 2025
➡️ buff.ly/uwqGQQm
💷 £37,500 - £42,000
🗓️ Apply by 30 September 2025
➡️ buff.ly/uwqGQQm
Reposted by Rui Guan
🆕 Blog! PhD student Glória Máté-Koncz explains the science of how we digest beans and how we study the digestion process here at the Quadram Institute 🫘
buff.ly/xuq1lcB
buff.ly/xuq1lcB
How do we digest beans? - Quadram Institute
PhD candidate Glória Máté-Koncz explains the science of how we digest beans and how we study the digestion process here at the Quadram Institute.
quadram.ac.uk
August 22, 2025 at 8:15 AM
🆕 Blog! PhD student Glória Máté-Koncz explains the science of how we digest beans and how we study the digestion process here at the Quadram Institute 🫘
buff.ly/xuq1lcB
buff.ly/xuq1lcB
Reposted by Rui Guan
Check out this week's blog from Dr Emily Jones at the @quadraminstitute.bsky.social to hear about her trip to Brussels for the Microphysiological Systems World Summit 2025. Great to see microbiology research in Norwich being shared with international audiences!
www.cmi-norwich.ac.uk/presenting-n...
www.cmi-norwich.ac.uk/presenting-n...
Presenting new research at an international conference: using microphysiological systems (MPS) to study microbial infections
Dr Emily Jones visits Brussels to share her latest findings and network with researchers from around the world.
www.cmi-norwich.ac.uk
August 14, 2025 at 9:51 AM
Check out this week's blog from Dr Emily Jones at the @quadraminstitute.bsky.social to hear about her trip to Brussels for the Microphysiological Systems World Summit 2025. Great to see microbiology research in Norwich being shared with international audiences!
www.cmi-norwich.ac.uk/presenting-n...
www.cmi-norwich.ac.uk/presenting-n...
Reposted by Rui Guan
📣 NEW PREPRINT 📝
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
Plant-associated fungi co-opt ancient antimicrobials for host manipulation
Evolutionary histories of effector proteins secreted by fungal pathogens to mediate plant colonization remain largely elusive. While most functionally characterized effectors modulate plant immunity, ...
www.biorxiv.org
August 15, 2025 at 7:47 AM
📣 NEW PREPRINT 📝
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
We identified evolutionary origins of many fungal effectors!
We show that fungi secrete lots of antimicrobial proteins, and that some of them were repurposed by plant pathogens for host immune suppression.
www.biorxiv.org/content/10.1...
cc @teamthomma.bsky.social
Reposted by Rui Guan
To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics.
I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
August 11, 2025 at 6:54 PM
To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics.
I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com 🧵(6/7)
Reposted by Rui Guan
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
August 11, 2025 at 6:54 PM
Introducing the 1,000 Flower Collection 🧬🌹
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.
Here’s how I’m making it happen… and how you can join me on this journey 🧵(1/7)
Reposted by Rui Guan
📢 New preprint alert!
We used comparative genomics on 72,000+ bacterial genomes to uncover the genetic basis of microbial adaptation to multicellular hosts—plants and animals alike.
www.biorxiv.org/content/10.1...
We used comparative genomics on 72,000+ bacterial genomes to uncover the genetic basis of microbial adaptation to multicellular hosts—plants and animals alike.
www.biorxiv.org/content/10.1...
The Genetic Basis of Bacterial Adaptation to Hosts
Microbes colonize and interact with diverse multicellular hosts using specialized genes, many of which remain unidentified. Better understanding of host-associated gene functions is a key aspect of mi...
www.biorxiv.org
July 21, 2025 at 6:40 AM
📢 New preprint alert!
We used comparative genomics on 72,000+ bacterial genomes to uncover the genetic basis of microbial adaptation to multicellular hosts—plants and animals alike.
www.biorxiv.org/content/10.1...
We used comparative genomics on 72,000+ bacterial genomes to uncover the genetic basis of microbial adaptation to multicellular hosts—plants and animals alike.
www.biorxiv.org/content/10.1...
Reposted by Rui Guan
Our paper on Pseudomonas intra-genus competition in SynComs on Arabidopsis roots is now out @plosbiology.org ! 🎉
If you want to chat about the story, visit poster 374 tomorrow, Thursday #2025ISMPMI
journals.plos.org/plosbiology/...
If you want to chat about the story, visit poster 374 tomorrow, Thursday #2025ISMPMI
journals.plos.org/plosbiology/...
Pseudomonas intra-genus competition determines the protective function of synthetic bacterial communities in Arabidopsis thaliana
The plant microbiome can protect its host against detrimental bacterial strains. This study shows that competition among Pseudomonas bacteria in synthetic bacterial communities determines how well the...
journals.plos.org
July 16, 2025 at 7:11 PM
Our paper on Pseudomonas intra-genus competition in SynComs on Arabidopsis roots is now out @plosbiology.org ! 🎉
If you want to chat about the story, visit poster 374 tomorrow, Thursday #2025ISMPMI
journals.plos.org/plosbiology/...
If you want to chat about the story, visit poster 374 tomorrow, Thursday #2025ISMPMI
journals.plos.org/plosbiology/...
Reposted by Rui Guan
Our researchers are running a study to assess different ways of helping vegans increase their daily intake of essential nutrients 🌿
✅ If you’d like to help us, register to take part
📣 Please RT and share!
➡️ buff.ly/4c2yGsP
✅ If you’d like to help us, register to take part
📣 Please RT and share!
➡️ buff.ly/4c2yGsP
July 13, 2025 at 12:27 PM
Our researchers are running a study to assess different ways of helping vegans increase their daily intake of essential nutrients 🌿
✅ If you’d like to help us, register to take part
📣 Please RT and share!
➡️ buff.ly/4c2yGsP
✅ If you’d like to help us, register to take part
📣 Please RT and share!
➡️ buff.ly/4c2yGsP
Reposted by Rui Guan
Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows
Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows
Previously, the only way to reduce levels of Pfas was by bloodletting or a drug with unpleasant side effects
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Certain kinds of gut microbes absorb toxic Pfas “forever chemicals” and help expel them from the body via feces, new first-of-its-kind University of Cambridge research shows.
The findings are welcome news as the only options that exist for reducing the level of dangerous Pfas compounds from the body are bloodletting and a cholesterol drug that induces unpleasant side effects. Continue reading...
www.theguardian.com
July 13, 2025 at 12:02 PM
Some gut microbes can absorb and help expel ‘forever chemicals’ from the body, research shows
Reposted by Rui Guan
Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 2, 2025 at 2:57 PM
Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rui Guan
Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
www.nature.com
July 1, 2025 at 10:03 AM
Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
Reposted by Rui Guan
Beautiful work from my friend @kiranrpatil.bsky.social . Gut bacteria can accumulate Forever chemicals and help us get rid of them! Happy we could contribute! www.nature.com/articles/s41...
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
www.nature.com
July 1, 2025 at 11:25 AM
Beautiful work from my friend @kiranrpatil.bsky.social . Gut bacteria can accumulate Forever chemicals and help us get rid of them! Happy we could contribute! www.nature.com/articles/s41...