Camp Lab
@graycamplab.bsky.social
Curiosity. Human Model Systems. Single-Cell Genomics. EvoDevo…and more!
We are searching for computational PhDs and Postdocs to join our group in collaboration with Barbara Treutlein's Lab. We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
October 25, 2025 at 3:10 AM
We are searching for computational PhDs and Postdocs to join our group in collaboration with Barbara Treutlein's Lab. We have exciting single-cell technology projects that incorporate bioengineering, computation, biology, translation. Send CV to deco_ihb@roche.com
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 22, 2025 at 9:04 PM
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
July 24, 2025 at 12:36 PM
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
We identify and functionally evaluate 2 human accelerated regions (HARs) at the IGFBP2 locus. Provocatively, these data indicate that the IGF pathway contributed to evolutionary change in the developing human intestine, potentially augmenting small intestine length. 10/11
July 24, 2025 at 12:36 PM
We identify and functionally evaluate 2 human accelerated regions (HARs) at the IGFBP2 locus. Provocatively, these data indicate that the IGF pathway contributed to evolutionary change in the developing human intestine, potentially augmenting small intestine length. 10/11
Organoid KO/Reporter assays confirm a bona fide Lactase expression enhancer within an MCM6 intron. Deep learning predicts that a selected SNP associated with lactase persistence removes a transcriptional repressor binding site, a potential mechanism for hypolactasia. 9/11
July 24, 2025 at 12:35 PM
Organoid KO/Reporter assays confirm a bona fide Lactase expression enhancer within an MCM6 intron. Deep learning predicts that a selected SNP associated with lactase persistence removes a transcriptional repressor binding site, a potential mechanism for hypolactasia. 9/11
We used a composite annotation to identify intestinal gene regulatory regions that have strong signatures of function and evolutionary change in humans. Willow plots aesthetically showcase the diverse gene ontologies affected by regulatory changes. 8/10
July 24, 2025 at 12:35 PM
We used a composite annotation to identify intestinal gene regulatory regions that have strong signatures of function and evolutionary change in humans. Willow plots aesthetically showcase the diverse gene ontologies affected by regulatory changes. 8/10
We identified conservation and divergence between human and chimpanzee intestinal epithelial gene regulation associated with metabolic and barrier functions. 7/10
July 24, 2025 at 12:35 PM
We identified conservation and divergence between human and chimpanzee intestinal epithelial gene regulation associated with metabolic and barrier functions. 7/10
Truly incredible chimpanzee intestinal tissues can be generated from chimpanzee pluripotent stem cells, providing a very exciting inroad into comparative species analysis! Builds on extraordinary work from @JimWellsLab @TheSpenceLab #organoids #evodevo 6/10
July 24, 2025 at 12:34 PM
Truly incredible chimpanzee intestinal tissues can be generated from chimpanzee pluripotent stem cells, providing a very exciting inroad into comparative species analysis! Builds on extraordinary work from @JimWellsLab @TheSpenceLab #organoids #evodevo 6/10
Pluripotent stem cells can generate intestinal organoid tissues that have remarkable similarity to primary tissue counterparts. We performed a multiplexed reporter assay to assess putative enhancers for activity in intestinal organoids. 5/10
July 24, 2025 at 12:34 PM
Pluripotent stem cells can generate intestinal organoid tissues that have remarkable similarity to primary tissue counterparts. We performed a multiplexed reporter assay to assess putative enhancers for activity in intestinal organoids. 5/10
We explored the evolution of cell types and gene regulation by comparing tissue and #organoids from humans, chimps, and mice. Many genes and reg. regions active in enterocytes and associated with barrier function and metabolism have signatures of recent change. 4/10
July 24, 2025 at 12:33 PM
We explored the evolution of cell types and gene regulation by comparing tissue and #organoids from humans, chimps, and mice. Many genes and reg. regions active in enterocytes and associated with barrier function and metabolism have signatures of recent change. 4/10
At birth, the human GI tract becomes exposed to the outside world. Prior to birth, gene regulatory networks must orchestrate intestinal development to prepare for dynamic diet and microbiota exposures, which change over lifespan. 3/10
July 24, 2025 at 12:33 PM
At birth, the human GI tract becomes exposed to the outside world. Prior to birth, gene regulatory networks must orchestrate intestinal development to prepare for dynamic diet and microbiota exposures, which change over lifespan. 3/10
Recent genetic change affects gut function, including variants involved in Crohn’s disease (CD), inflammatory bowel disease (IBD), and hypolactasia. An evolutionary perspective on the developing intestine has human health relevance and can shed light on modern GI disorders. 2/10
July 24, 2025 at 12:32 PM
Recent genetic change affects gut function, including variants involved in Crohn’s disease (CD), inflammatory bowel disease (IBD), and hypolactasia. An evolutionary perspective on the developing intestine has human health relevance and can shed light on modern GI disorders. 2/10
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
July 24, 2025 at 12:32 PM
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
July 11, 2025 at 8:59 PM
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social @jasperjanssens.bsky.social and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with Rubén López-Sandoval, Marius F. Harter, Qianhui Yu, Matthias Lütolf, Mikhail Nikolaev, and Nikolche Gjorevski! biorxiv.org/content/10.1...
May 9, 2025 at 12:54 PM
Modular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with Rubén López-Sandoval, Marius F. Harter, Qianhui Yu, Matthias Lütolf, Mikhail Nikolaev, and Nikolche Gjorevski! biorxiv.org/content/10.1...
Learned a lot working with Jonas Fleck, Daniil Bobrovskiy, Dominik Klein, Barbara Treutlein and @fabiantheis.bsky.social on CellFlow: generative single-cell phenotype modeling with flow matching. Virtual protocol screening is particularly innovative!
May 3, 2025 at 8:58 PM
Learned a lot working with Jonas Fleck, Daniil Bobrovskiy, Dominik Klein, Barbara Treutlein and @fabiantheis.bsky.social on CellFlow: generative single-cell phenotype modeling with flow matching. Virtual protocol screening is particularly innovative!
It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!
April 28, 2025 at 2:33 PM
It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!
We are searching for a Master's Student/Intern to join the group for 6-12 months to work on large-scale bioimage analysis of complex human model system data!
Please send your CV to: deco_ihb@roche.com #IHB
Please send your CV to: deco_ihb@roche.com #IHB
January 31, 2025 at 8:35 AM
We are searching for a Master's Student/Intern to join the group for 6-12 months to work on large-scale bioimage analysis of complex human model system data!
Please send your CV to: deco_ihb@roche.com #IHB
Please send your CV to: deco_ihb@roche.com #IHB
Incorporation of tissue-resident immune cells into autologous human intestinal organoids can be used to study clinically manifested intestinal inflammation associated with T-cell bispecific antibodies! Collab with Nikolche Gjorevski and Laurianne Cabon @nature.com www.nature.com/articles/s41...
December 20, 2024 at 10:40 PM
Incorporation of tissue-resident immune cells into autologous human intestinal organoids can be used to study clinically manifested intestinal inflammation associated with T-cell bispecific antibodies! Collab with Nikolche Gjorevski and Laurianne Cabon @nature.com www.nature.com/articles/s41...
Check out our review @natrevgenet.bsky.social: "Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution" www.nature.com/articles/s41...
December 20, 2024 at 10:26 PM
Check out our review @natrevgenet.bsky.social: "Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution" www.nature.com/articles/s41...
An integrated neural organoid atlas helps us all stand on the shoulders of great scientists! Led by Barbara Treutlein and Fabian Theis labs, we explore coverage and fidelity, provide tools to assess new protocols, and use the diverse cohort to assess disease models. www.nature.com/articles/s41...
November 21, 2024 at 4:59 PM
An integrated neural organoid atlas helps us all stand on the shoulders of great scientists! Led by Barbara Treutlein and Fabian Theis labs, we explore coverage and fidelity, provide tools to assess new protocols, and use the diverse cohort to assess disease models. www.nature.com/articles/s41...
fwiw, evolutionary conservation is also an extremely valuable tool and it pointed us to intron 3 as a location of regulatory function for zebrafish Angptl4:
November 18, 2024 at 9:45 PM
fwiw, evolutionary conservation is also an extremely valuable tool and it pointed us to intron 3 as a location of regulatory function for zebrafish Angptl4:
My switch to genomics-guided (aka high information content) biology came from old-school FAIRE data that identified regions of regulatory function (which overlapped 1-1 with my functional experiments). Had I these maps from the beginning of my PhD, I would have had way less anxiety in my Phd work!
November 18, 2024 at 9:43 PM
My switch to genomics-guided (aka high information content) biology came from old-school FAIRE data that identified regions of regulatory function (which overlapped 1-1 with my functional experiments). Had I these maps from the beginning of my PhD, I would have had way less anxiety in my Phd work!
Super cool part of the story was that intestinal expression is altered by microbiota, an evo conserved phenomena: www.pnas.org/doi/10.1073/...
The enterocyte gene regulatory module was also responsive to microbiota.
The enterocyte gene regulatory module was also responsive to microbiota.
November 18, 2024 at 9:34 PM
Super cool part of the story was that intestinal expression is altered by microbiota, an evo conserved phenomena: www.pnas.org/doi/10.1073/...
The enterocyte gene regulatory module was also responsive to microbiota.
The enterocyte gene regulatory module was also responsive to microbiota.
This was how it all ended 🤔 ....I/we almost figured out how this gene was regulated in the zebrafish intestine. Single-base mutation in the GATA site looked promising...TF pulldowns looked promising....but it remains a mystery....and it ignited a never-ending search inside of me for explanations! 😃
November 18, 2024 at 9:16 PM
This was how it all ended 🤔 ....I/we almost figured out how this gene was regulated in the zebrafish intestine. Single-base mutation in the GATA site looked promising...TF pulldowns looked promising....but it remains a mystery....and it ignited a never-ending search inside of me for explanations! 😃