Graham Erwin
@grahamerwin.bsky.social
Asst. Professor, Baylor College of Medicine. Previously Stanford and UW–Madison. We use molecules and genomes to understand repetitive DNA sequences. #FirstGenAcademic ErwinLab.org
ASHG25 Poster 4106 Today at 2:30pm! Whole-genome long-read sequencing from 10 NANOGRAMS, not micrograms! ULI-HiFi delivers:
✅ 99.82% F1 for SNVs
✅ 98.9% TR accuracy
✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function
✅ 99.82% F1 for SNVs
✅ 98.9% TR accuracy
✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function
October 17, 2025 at 5:23 PM
ASHG25 Poster 4106 Today at 2:30pm! Whole-genome long-read sequencing from 10 NANOGRAMS, not micrograms! ULI-HiFi delivers:
✅ 99.82% F1 for SNVs
✅ 98.9% TR accuracy
✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function
✅ 99.82% F1 for SNVs
✅ 98.9% TR accuracy
✅ Discovered LIMD1 TR expansion progressively increasing from normal→polyp→adenocarcinoma, with evidence of function
At ASHG25 RIGHT NOW: Deep-coverage PacBio HiFi sequencing reveals hotspots of tandem repeat variation in the male germline. 12 men, paired blood/sperm, 1.7M repeats analyzed. What we found about mutational bias will surprise you! Poster 6044W, 2:30-4:30pm today. Lucas Finot presenting.
October 15, 2025 at 6:13 PM
At ASHG25 RIGHT NOW: Deep-coverage PacBio HiFi sequencing reveals hotspots of tandem repeat variation in the male germline. 12 men, paired blood/sperm, 1.7M repeats analyzed. What we found about mutational bias will surprise you! Poster 6044W, 2:30-4:30pm today. Lucas Finot presenting.
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter
October 8, 2025 at 8:05 PM
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Reposted by Graham Erwin
A follow-up to my quote of the day this morning:
A short Bluetorial about Vannevar Bush and his legacy
A short Bluetorial about Vannevar Bush and his legacy
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
April 15, 2025 at 12:50 PM
A follow-up to my quote of the day this morning:
A short Bluetorial about Vannevar Bush and his legacy
A short Bluetorial about Vannevar Bush and his legacy
Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies! continuingstudies.stanford.edu/courses/prof...
Modern Grant Writing with AI
AI is transforming grant writing—turning a time-intensive task into a more strategic, efficient process that elevates both research and storytelling. This hands-on course explores how to integrate AI ...
continuingstudies.stanford.edu
May 21, 2025 at 3:44 PM
Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies! continuingstudies.stanford.edu/courses/prof...
Reposted by Graham Erwin
Big: The final version of a randomized, controlled World Bank study finds using a GPT-4 tutor with teacher guidance in a six week afterschool program in Nigeria had "more than twice the effect of some of the most effective interventions in education" ("equating to 1.5 to 2 years" of standard school)
May 20, 2025 at 8:07 PM
Big: The final version of a randomized, controlled World Bank study finds using a GPT-4 tutor with teacher guidance in a six week afterschool program in Nigeria had "more than twice the effect of some of the most effective interventions in education" ("equating to 1.5 to 2 years" of standard school)
Reposted by Graham Erwin
I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamerwin.bsky.social and met so many amazing people!
It was a thought-provoking and reflective weekend with lessons that I will carry with me!
What a privilege to partake in such a transformative experience! 🥰
It was a thought-provoking and reflective weekend with lessons that I will carry with me!
What a privilege to partake in such a transformative experience! 🥰
May 19, 2025 at 2:16 AM
I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamerwin.bsky.social and met so many amazing people!
It was a thought-provoking and reflective weekend with lessons that I will carry with me!
What a privilege to partake in such a transformative experience! 🥰
It was a thought-provoking and reflective weekend with lessons that I will carry with me!
What a privilege to partake in such a transformative experience! 🥰
Reposted by Graham Erwin
A first in human genomics: a 4-generation pedigree reference, now in Nature.
Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions.
Paper here: go.nature.com/4lGMPlP
#TheresHiFiForThat
Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions.
Paper here: go.nature.com/4lGMPlP
#TheresHiFiForThat
April 24, 2025 at 3:34 PM
A first in human genomics: a 4-generation pedigree reference, now in Nature.
Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions.
Paper here: go.nature.com/4lGMPlP
#TheresHiFiForThat
Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions.
Paper here: go.nature.com/4lGMPlP
#TheresHiFiForThat
There are a number of tools (Elicit, Perplexity, Google's Deep Research, Consensus within ChatGPT) to find references. One of the complaints from academics is these tools don't find "the right papers".
So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)
So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)
ChatGPT
A conversational AI system that listens, learns, and challenges
chatgpt.com
April 16, 2025 at 9:21 PM
There are a number of tools (Elicit, Perplexity, Google's Deep Research, Consensus within ChatGPT) to find references. One of the complaints from academics is these tools don't find "the right papers".
So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)
So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)
The LLM (AMIE in this case) performs higher (59.1% top-10 accuracy) than the clinician with the LLM (51.7%).
Another study consistent with what @emollick.bsky.social has been sharing for a while now.
www.nature.com/articles/s41...
Another study consistent with what @emollick.bsky.social has been sharing for a while now.
www.nature.com/articles/s41...
April 11, 2025 at 8:54 PM
The LLM (AMIE in this case) performs higher (59.1% top-10 accuracy) than the clinician with the LLM (51.7%).
Another study consistent with what @emollick.bsky.social has been sharing for a while now.
www.nature.com/articles/s41...
Another study consistent with what @emollick.bsky.social has been sharing for a while now.
www.nature.com/articles/s41...
Reposted by Graham Erwin
Updated this chart with the newest Gemini. It shows the rapid progress in AI over less than two years: costs for GPT-4 class models has dropped 99.7% and even the most advanced models (beating PhDs at the GPQA) are still 82% cheaper than GPT-4.
Probably not worth betting on this trend ending soon.
Probably not worth betting on this trend ending soon.
April 4, 2025 at 6:12 PM
Updated this chart with the newest Gemini. It shows the rapid progress in AI over less than two years: costs for GPT-4 class models has dropped 99.7% and even the most advanced models (beating PhDs at the GPQA) are still 82% cheaper than GPT-4.
Probably not worth betting on this trend ending soon.
Probably not worth betting on this trend ending soon.
Reposted by Graham Erwin
A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB
First post here! To inaugurate this account, I'd like to share my recent work, now published in JACS.
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling
The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...
pubs.acs.org
March 27, 2025 at 11:36 PM
A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB
Reposted by Graham Erwin
The strchive.org paper is out!!
The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases.
🖥️ 🧬
link.springer.com/article/10.1...
The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases.
🖥️ 🧬
link.springer.com/article/10.1...
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine
Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...
link.springer.com
March 26, 2025 at 8:01 PM
The strchive.org paper is out!!
The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases.
🖥️ 🧬
link.springer.com/article/10.1...
The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases.
🖥️ 🧬
link.springer.com/article/10.1...
Reposted by Graham Erwin
A new article from Laurel Hiatt and @hdashnow.bsky.social describing STRchive is now available at Genome Medicine. genomemedicine.biomedcentral.com/articles/10....
Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci."
strchive.org
Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci."
strchive.org
STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine
Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...
genomemedicine.biomedcentral.com
March 26, 2025 at 7:18 PM
A new article from Laurel Hiatt and @hdashnow.bsky.social describing STRchive is now available at Genome Medicine. genomemedicine.biomedcentral.com/articles/10....
Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci."
strchive.org
Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci."
strchive.org
Reposted by Graham Erwin
Evidence that a well prompted LLM can help learning from a (small, single-subject) randomized controlled trial at Harvard: “here we show that students learn more than twice as much in less time with an AI tutor compared to an active learning classroom, while also being more engaged and motivated.”
March 21, 2025 at 5:47 PM
Evidence that a well prompted LLM can help learning from a (small, single-subject) randomized controlled trial at Harvard: “here we show that students learn more than twice as much in less time with an AI tutor compared to an active learning classroom, while also being more engaged and motivated.”
Reposted by Graham Erwin
We don't spend a penny on marketing. It's all word of mouth for @costplusdrugs.com
That's how we keep prices so low. Please spread the word !
That's how we keep prices so low. Please spread the word !
March 14, 2025 at 3:32 AM
We don't spend a penny on marketing. It's all word of mouth for @costplusdrugs.com
That's how we keep prices so low. Please spread the word !
That's how we keep prices so low. Please spread the word !
Reposted by Graham Erwin
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
Reposted by Graham Erwin
5 yr anniversary of the day I started my COVID ICU visit
March 12, 2025 at 7:30 PM
5 yr anniversary of the day I started my COVID ICU visit
Reposted by Graham Erwin
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
investors.beamtx.com
March 10, 2025 at 11:48 AM
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
Reposted by Graham Erwin
Excited to share the peer-reviewed version of our paper, which is out today!!
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern
Bispecific antibodies incorporating a cross-reactive NTD-specific antibody are resilient to SARS-CoV-2 variants of concern.
www.science.org
March 6, 2025 at 2:13 PM
Excited to share the peer-reviewed version of our paper, which is out today!!
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Graham Erwin
Researchers from @pollyfordyce.bsky.social lab explore what makes some transcription factors more or less selective for their DNA ligands. This work could guide the design of more selective DNA-binding proteins for many bioengineering applications:
Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways - Nature Communications
In this work, high-throughput microfluidic assays reveal how allosteric substitutions that alter folding-and-binding pathways shape DNA specificity and selectivity landscapes in the human…
buff.ly
March 6, 2025 at 5:00 PM
Researchers from @pollyfordyce.bsky.social lab explore what makes some transcription factors more or less selective for their DNA ligands. This work could guide the design of more selective DNA-binding proteins for many bioengineering applications:
Reposted by Graham Erwin
ChatGPT Code Interpreter is still my favorite implementation of the pattern where an LLM can write code, run it, see any errors and iterate to fix them
It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...
It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...
Demo of ChatGPT Code Interpreter running in o3-mini-high
OpenAI made GPT-4.5 available to Plus ($20/month) users today. I was [a little disappointed](https://simonwillison.net/2025/Feb/27/introducing-gpt-45/) with GPT-4.5 when I tried it through the API, bu...
simonwillison.net
March 5, 2025 at 11:11 PM
ChatGPT Code Interpreter is still my favorite implementation of the pattern where an LLM can write code, run it, see any errors and iterate to fix them
It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...
It's been stuck on GPT-4o for ages - today it got a huge upgrade and now work with GPT4.5 and o3-mini! simonwillison.net/2025/Mar/5/c...
Reposted by Graham Erwin
As #AGBT approaches, discover how #PacBio SPRQ chemistry for Revio is advancing #HiFisequencing efficiency, reducing costs, and unlocking new research possibilities. bit.ly/4g89HXK
#AGBT25
#AGBT25
Lighting a SPRQ: How new Revio chemistry fuels innovative research - PacBio
New SPRQ chemistry for the Revio system is revolutionizing HiFi sequencing with increased efficiency, affordability, and reduced DNA input. Learn about its impact on research in rare diseases, cancer, and multiomics.
bit.ly
February 19, 2025 at 5:30 PM
As #AGBT approaches, discover how #PacBio SPRQ chemistry for Revio is advancing #HiFisequencing efficiency, reducing costs, and unlocking new research possibilities. bit.ly/4g89HXK
#AGBT25
#AGBT25
Reposted by Graham Erwin
We are starting to see what "AI will accelerate science" actually looks like.
This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.
This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.
February 19, 2025 at 5:52 PM
We are starting to see what "AI will accelerate science" actually looks like.
This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.
This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.
Reposted by Graham Erwin
At #BPS2025? Check out the posters by @sovannytaylor.bsky.social and @gtleung.bsky.social on Monday. Venom peptides as tools to study cell penetrance and designer condensates to probe cytoplasmic rheology across length scales.
February 15, 2025 at 5:13 PM
At #BPS2025? Check out the posters by @sovannytaylor.bsky.social and @gtleung.bsky.social on Monday. Venom peptides as tools to study cell penetrance and designer condensates to probe cytoplasmic rheology across length scales.