Gokilavani(Goks) Thangavel
@gokilavani.bsky.social
Postdoctoral researcher working with human centromeres in @erhardtlab
Doctoral research was on holocentromeres of the plant Rhynchospora
Doctoral research was on holocentromeres of the plant Rhynchospora
Reposted by Gokilavani(Goks) Thangavel
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 4:21 PM
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Reposted by Gokilavani(Goks) Thangavel
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
www.nature.com
November 4, 2025 at 1:17 PM
We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
With @jiyeonleem.bsky.social and our team at Yale MCDB.
Read: www.nature.com/articles/s43...
Reposted by Gokilavani(Goks) Thangavel
I spoke to Renaud Pourpe (of @lonelypipette.bsky.social fame with @epigenetique.bsky.social) about the unique challenges faced by postdocs and early-career PIs worldwide on the transition from postdoc to PI.
Lots of useful advice shared (by others):
www.alba.network/diversity-po...
Check it out.
Lots of useful advice shared (by others):
www.alba.network/diversity-po...
Check it out.
ALBA-IBRO Diversity Podcast - Season 2
Episode 4 is out. In season 2, we focus on the transition from postdoc to PI, highlighting the unique challenges faced by postdocs and early-career PIs worldwide. Hosted by the Lonely Pipette.
www.alba.network
August 2, 2025 at 11:01 PM
I spoke to Renaud Pourpe (of @lonelypipette.bsky.social fame with @epigenetique.bsky.social) about the unique challenges faced by postdocs and early-career PIs worldwide on the transition from postdoc to PI.
Lots of useful advice shared (by others):
www.alba.network/diversity-po...
Check it out.
Lots of useful advice shared (by others):
www.alba.network/diversity-po...
Check it out.
Reposted by Gokilavani(Goks) Thangavel
🧵𝐀 𝐭𝐡𝐫𝐞𝐚𝐝 𝐰𝐢𝐭𝐡 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐥𝐚𝐛 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬: 🧵
#1️⃣
Hofstatter, Thangavel, Lux et al. 2022 𝘊𝘦𝘭𝘭: 𝗥𝗲𝗽𝗲𝗮𝘁-𝗯𝗮𝘀𝗲𝗱 𝗵𝗼𝗹𝗼𝗰𝗲𝗻𝘁𝗿𝗼𝗺𝗲𝗿𝗲𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗮𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗮𝗻𝗱 𝗸𝗮𝗿𝘆𝗼𝘁𝘆𝗽𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻
www.cell.com/cell/fulltex...
@gokilavani.bsky.social
#PlantSciences #Chromosome #Genomics #Meiosis4eva #Centromere
🌱🧬🔬
#1️⃣
Hofstatter, Thangavel, Lux et al. 2022 𝘊𝘦𝘭𝘭: 𝗥𝗲𝗽𝗲𝗮𝘁-𝗯𝗮𝘀𝗲𝗱 𝗵𝗼𝗹𝗼𝗰𝗲𝗻𝘁𝗿𝗼𝗺𝗲𝗿𝗲𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗮𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗮𝗻𝗱 𝗸𝗮𝗿𝘆𝗼𝘁𝘆𝗽𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻
www.cell.com/cell/fulltex...
@gokilavani.bsky.social
#PlantSciences #Chromosome #Genomics #Meiosis4eva #Centromere
🌱🧬🔬
Repeat-based holocentromeres influence genome architecture and karyotype evolution
While most eukaryotes contain single regional centromeres, several plant and animal
lineages assemble holocentromeres along the entire chromosome length. The assembly
of chromosome-scale holocentric g...
www.cell.com
November 13, 2024 at 8:39 AM
🧵𝐀 𝐭𝐡𝐫𝐞𝐚𝐝 𝐰𝐢𝐭𝐡 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐥𝐚𝐛 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬: 🧵
#1️⃣
Hofstatter, Thangavel, Lux et al. 2022 𝘊𝘦𝘭𝘭: 𝗥𝗲𝗽𝗲𝗮𝘁-𝗯𝗮𝘀𝗲𝗱 𝗵𝗼𝗹𝗼𝗰𝗲𝗻𝘁𝗿𝗼𝗺𝗲𝗿𝗲𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗮𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗮𝗻𝗱 𝗸𝗮𝗿𝘆𝗼𝘁𝘆𝗽𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻
www.cell.com/cell/fulltex...
@gokilavani.bsky.social
#PlantSciences #Chromosome #Genomics #Meiosis4eva #Centromere
🌱🧬🔬
#1️⃣
Hofstatter, Thangavel, Lux et al. 2022 𝘊𝘦𝘭𝘭: 𝗥𝗲𝗽𝗲𝗮𝘁-𝗯𝗮𝘀𝗲𝗱 𝗵𝗼𝗹𝗼𝗰𝗲𝗻𝘁𝗿𝗼𝗺𝗲𝗿𝗲𝘀 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗮𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗮𝗻𝗱 𝗸𝗮𝗿𝘆𝗼𝘁𝘆𝗽𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻
www.cell.com/cell/fulltex...
@gokilavani.bsky.social
#PlantSciences #Chromosome #Genomics #Meiosis4eva #Centromere
🌱🧬🔬
Reposted by Gokilavani(Goks) Thangavel
I put together a list of profiles in somehow related subjects of chromosome biology
go.bsky.app/KqsM3kd
go.bsky.app/KqsM3kd
November 12, 2024 at 12:00 PM
I put together a list of profiles in somehow related subjects of chromosome biology
go.bsky.app/KqsM3kd
go.bsky.app/KqsM3kd
Reposted by Gokilavani(Goks) Thangavel
Want to learn more about the tricks and tips for generating ONT Ultra-long DNA? The T2T Consortium and UCSC SeqTech Center are hosting a Technology-focused Webinar next Thursday with a group of experts.
Register today: bit.ly/3PFTa2f @aphillippy.bsky.social
Register today: bit.ly/3PFTa2f @aphillippy.bsky.social
March 28, 2024 at 10:19 AM
Want to learn more about the tricks and tips for generating ONT Ultra-long DNA? The T2T Consortium and UCSC SeqTech Center are hosting a Technology-focused Webinar next Thursday with a group of experts.
Register today: bit.ly/3PFTa2f @aphillippy.bsky.social
Register today: bit.ly/3PFTa2f @aphillippy.bsky.social