Keshav Kishor
@glycans.bsky.social
Chemical biologist #glycotime #chemsky #chembio
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
www.youtube.com
November 1, 2025 at 12:07 AM
Reposted by Keshav Kishor
Undergrad and grad #chemistry students, Merck now has applications open for 2026 internships and co-ops in their Future Talent Program!
Includes discovery, process, chembio,
and computational roles.
One of the directors compiled a list here: www.linkedin.com/pos...
#chemsky
Includes discovery, process, chembio,
and computational roles.
One of the directors compiled a list here: www.linkedin.com/pos...
#chemsky
#internship #co #chemistry #merck #merckchemistry #futuretalentprogram #ftp2026 | Nunzio Sciammetta
Merck is hiring 2026 interns & co‑ops across Chemistry disciplines (organic synthesis, enabling technologies, analytical, computational modeling, chemoinformatics, chemical biology, and more) into the Future Talent Program.
Below are links to current openings. Please review the job descriptions carefully and apply to the role that best matches your scientific interests and skills.
Quick tips: tailor your resume/cover letter to the specific role, highlight relevant techniques/projects, scientific interests, coursework, and hands‑on practical skills, and apply early.
Discovery and Process Chemistry Intern: https://lnkd.in/e32PwK7b
Discovery and Process Chemistry Co-op: https://lnkd.in/epy5cDSU
Chemical Biology Intern: https://lnkd.in/ejE46Qid
Protein & Structural Chemistry: https://lnkd.in/eJfaG9Ti
Computational Modeling & Informatics: https://lnkd.in/eWsEx2x2
Discovery Sample Management Analytical Chemistry intern: https://lnkd.in/epqm58ea
Discovery Sample Management Automation intern: https://lnkd.in/ePwvueYQ
DPTM Operations Intern: https://lnkd.in/eVxqtz-2
Chemical Engineering Research & Development Intern: https://lnkd.in/eAae4i2K
Chemical Biotechnologies Intern: https://lnkd.in/eUpyuewv
Chemical Biotechnologies Co-Op: https://lnkd.in/e4JgtGC2
Data Rich Experimentation Intern: https://lnkd.in/epwNDnG8
Analytical Research & Development Intern: https://lnkd.in/e3rhrNVM
Analytical Research & Development Co-Op: https://lnkd.in/e49Gupg8
#internship #co‑op #chemistry #Merck #MerckChemistry #FutureTalentProgram #FTP2026
www.linkedin.com
October 7, 2025 at 4:50 PM
Undergrad and grad #chemistry students, Merck now has applications open for 2026 internships and co-ops in their Future Talent Program!
Includes discovery, process, chembio,
and computational roles.
One of the directors compiled a list here: www.linkedin.com/pos...
#chemsky
Includes discovery, process, chembio,
and computational roles.
One of the directors compiled a list here: www.linkedin.com/pos...
#chemsky
Reposted by Keshav Kishor
Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration
October 7, 2025 at 2:07 PM
Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration
Reposted by Keshav Kishor
Just 2 weeks away!! Oct 15 at 12 Noon ET. Join us for the next ACS-DOC @organicdivision.org Virtual Symposium featuring Prof. Marvin Parasram (NYU) and Prof. Brian Stoltz (CalTech)
Free to watch/ no registration - just tune in on YouTube or Zoom with the links in the post below
#ChemSky
Free to watch/ no registration - just tune in on YouTube or Zoom with the links in the post below
#ChemSky
🚨Save the Date!! Oct 15 at 12 noon ET! 🚨
The next ACS Organic @organicdivision.org Virtual Symposium ft. Prof. Marvin Parasram (NYU) & Prof. Brian Stoltz (CalTech)
Thank you Beyond CCHF for hosting!
Free to watch
YouTube: orgn.link/watch
Zoom: emory.zoom.us/j/185635071
#ChemSky
The next ACS Organic @organicdivision.org Virtual Symposium ft. Prof. Marvin Parasram (NYU) & Prof. Brian Stoltz (CalTech)
Thank you Beyond CCHF for hosting!
Free to watch
YouTube: orgn.link/watch
Zoom: emory.zoom.us/j/185635071
#ChemSky
October 1, 2025 at 5:31 PM
Just 2 weeks away!! Oct 15 at 12 Noon ET. Join us for the next ACS-DOC @organicdivision.org Virtual Symposium featuring Prof. Marvin Parasram (NYU) and Prof. Brian Stoltz (CalTech)
Free to watch/ no registration - just tune in on YouTube or Zoom with the links in the post below
#ChemSky
Free to watch/ no registration - just tune in on YouTube or Zoom with the links in the post below
#ChemSky
Reposted by Keshav Kishor
Enzyme-Activated Sugar-Coated Bifunctional Degraders
Enzyme-Activated Sugar-Coated Bifunctional Degraders
Targeted protein degradation with compounds like proteolysis targeting chimeras (PROTACs) directs disease-associated proteins to the E3 ligase ubiquitin-proteasome system for removal. However, commonl...
pubs.acs.org
September 29, 2025 at 1:02 PM
Enzyme-Activated Sugar-Coated Bifunctional Degraders
Reposted by Keshav Kishor
The @US_FDA approved imlunestrant, a selective estrogen receptor degrader or SERD, for adults with ER-positive, HER2-negative, advanced breast cancer with ESR1 mutations that has progressed following treatment with endocrine therapy: buff.ly/fUrc6Vw
FDA approves imlunestrant
On September 25, 2025, the Food and Drug Administration approved imlunestrant (Inluriyo, Eli Lilly and Company).
www.fda.gov
September 25, 2025 at 7:46 PM
The @US_FDA approved imlunestrant, a selective estrogen receptor degrader or SERD, for adults with ER-positive, HER2-negative, advanced breast cancer with ESR1 mutations that has progressed following treatment with endocrine therapy: buff.ly/fUrc6Vw
Reposted by Keshav Kishor
This definition sounds unnecessarily complicated for something that essentially means "adding seasoning to a pathogen before eating it"
August 25, 2025 at 10:16 PM
This definition sounds unnecessarily complicated for something that essentially means "adding seasoning to a pathogen before eating it"
Reposted by Keshav Kishor
Good ideas come from having lots of experience. And experience comes from having lots of bad ideas.
August 25, 2025 at 3:00 AM
Good ideas come from having lots of experience. And experience comes from having lots of bad ideas.
Reposted by Keshav Kishor
Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis
Open access 🔓
Open access 🔓
Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis
In this study, we profiled 11 structurally related von Hippel–Lindau (VHL)-based proteolysis-targeting chimeras (PROTACs), evaluating in vivo pharmacokinetics in mice (oral bioavailability and clearan...
pubs.acs.org
August 25, 2025 at 11:55 AM
Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis
Open access 🔓
Open access 🔓
Reposted by Keshav Kishor
Why would anyone want to be a scientist? There are the pleasures of:
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
August 15, 2025 at 8:30 PM
Why would anyone want to be a scientist? There are the pleasures of:
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
Reposted by Keshav Kishor
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cere...
www.science.org
August 5, 2025 at 1:50 PM
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
Reposted by Keshav Kishor
it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
July 31, 2025 at 2:50 PM
it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond
Reposted by Keshav Kishor
“I trust it as far as I can throw it” is basically mass spec
Determining how you feel about things by throwing them real hard
Determining how you feel about things by throwing them real hard
July 28, 2025 at 7:49 PM
“I trust it as far as I can throw it” is basically mass spec
Determining how you feel about things by throwing them real hard
Determining how you feel about things by throwing them real hard
Reposted by Keshav Kishor
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
May 2, 2025 at 8:52 AM
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
www.nature.com
July 29, 2025 at 1:09 PM
Reposted by Keshav Kishor
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
July 26, 2025 at 5:35 PM
First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
This book is the guide I wish I’d had then, with the goal of helping others now.
jenheemstra.com/book
Reposted by Keshav Kishor
Having a 1on1 with my supervisor at work and out of the coffee kiosk comes @nagiblab.bsky.social - definitely turned into a great day - had no idea we had a visit on - topped it off with a fantastic chem chat - Thanks Dave! Here’s a cool Nagib lab paper for sharing #ChemSky
Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals
A radical mechanism enables simple and robust access to nonstabilized, alkyl iron carbenes for novel (2 + 1) cycloadditions. This Fe-catalyzed strategy employs simple, aliphatic aldehydes as carbene p...
pubs.acs.org
June 17, 2025 at 11:38 PM
Having a 1on1 with my supervisor at work and out of the coffee kiosk comes @nagiblab.bsky.social - definitely turned into a great day - had no idea we had a visit on - topped it off with a fantastic chem chat - Thanks Dave! Here’s a cool Nagib lab paper for sharing #ChemSky
Reposted by Keshav Kishor
A past experience with target selection reminded me of the uncertainty and messiness of drug discovery.
medchemash.substack.com/p/the-moving...
medchemash.substack.com/p/the-moving...
The moving target
A past experience with target selection reminded me of the uncertainty and messiness of drug discovery.
medchemash.substack.com
June 16, 2025 at 9:13 PM
A past experience with target selection reminded me of the uncertainty and messiness of drug discovery.
medchemash.substack.com/p/the-moving...
medchemash.substack.com/p/the-moving...
Reposted by Keshav Kishor
“I’m Rapping my PhD” Which conference does that?!?! Vaibhav Mahajan. Out of this world
#theconferencetoendallconferences #TCTeAC
#theconferencetoendallconferences #TCTeAC
June 10, 2025 at 5:06 PM
“I’m Rapping my PhD” Which conference does that?!?! Vaibhav Mahajan. Out of this world
#theconferencetoendallconferences #TCTeAC
#theconferencetoendallconferences #TCTeAC
Reposted by Keshav Kishor
On the cover of this week's #JACS: "Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols"
Read it here 🔗 buff.ly/FJkPjYc
#ChemSky
Read it here 🔗 buff.ly/FJkPjYc
#ChemSky
June 6, 2025 at 12:02 PM
On the cover of this week's #JACS: "Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols"
Read it here 🔗 buff.ly/FJkPjYc
#ChemSky
Read it here 🔗 buff.ly/FJkPjYc
#ChemSky
Reposted by Keshav Kishor
Typeset version of our latest #glycotime paper now online!
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells
In BriefInsect cell lines are frequently used for expression of recombinant glycoproteins,
including vaccines. Using two independent approaches, we show that the endogenous
N-glycomes of High Five and...
www.mcponline.org
May 31, 2025 at 12:29 AM
Typeset version of our latest #glycotime paper now online!
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...
Reposted by Keshav Kishor
Reposted by Keshav Kishor
She grabs the pipette thinking "maybe I should publish this SAR" but then remembers Wuxi just delivered 200 compounds that look like they were made by blindfolded undergrads and the biology team needs them screened by tomorrow and Legal still hasn't
Why don’t medicinal chemists from industry publish anymore?
The rise of biotech and outsourcing in recent decades may be behind a big drop in papers.
cen.acs.org/business/don... #chemsky 🧪
The rise of biotech and outsourcing in recent decades may be behind a big drop in papers.
cen.acs.org/business/don... #chemsky 🧪
Why don’t medicinal chemists from industry publish anymore?
The rise of biotech and outsourcing in recent decades may be behind a big drop in papers
cen.acs.org
May 29, 2025 at 2:59 AM
She grabs the pipette thinking "maybe I should publish this SAR" but then remembers Wuxi just delivered 200 compounds that look like they were made by blindfolded undergrads and the biology team needs them screened by tomorrow and Legal still hasn't
Reposted by Keshav Kishor
Many people are busy doing recipe science.. If you ask a grad student what they need to do to get a paper, they'll tell you this & this, & they'll know that 2 years before the project is done. And I'm thinking, what's wrong with this picture?
Eve Marder, on @nightsciencepod.bsky.social
Eve Marder, on @nightsciencepod.bsky.social
May 26, 2025 at 11:11 PM
Many people are busy doing recipe science.. If you ask a grad student what they need to do to get a paper, they'll tell you this & this, & they'll know that 2 years before the project is done. And I'm thinking, what's wrong with this picture?
Eve Marder, on @nightsciencepod.bsky.social
Eve Marder, on @nightsciencepod.bsky.social