@giovton.bsky.social
We demonstrate that PINK1 sequesters the master regulator HNF4alpha, hampering DNA repair.
Blocking mitophagy reduce survival of persister cells; patients whose cancer cells show signatures of increased mitophagy present a shorter survival.
Blocking mitophagy reduce survival of persister cells; patients whose cancer cells show signatures of increased mitophagy present a shorter survival.
February 4, 2025 at 9:42 PM
We demonstrate that PINK1 sequesters the master regulator HNF4alpha, hampering DNA repair.
Blocking mitophagy reduce survival of persister cells; patients whose cancer cells show signatures of increased mitophagy present a shorter survival.
Blocking mitophagy reduce survival of persister cells; patients whose cancer cells show signatures of increased mitophagy present a shorter survival.
Among the few pathways upregulated in persister cells, there was #mitophagy. Indeed mitochondrial turnover and neo-synthesis was strongly activated in persister cells, driven by PINK1.
February 4, 2025 at 9:42 PM
Among the few pathways upregulated in persister cells, there was #mitophagy. Indeed mitochondrial turnover and neo-synthesis was strongly activated in persister cells, driven by PINK1.
Upon prolonged exposure, tolerant cells morph into a persistence status, where DNA repair is reduced. @daweonline.bsky.social using #scGETseq revealed that in persister cells chromatin became pervasively compacted with concomitant transcriptional reduction.
February 4, 2025 at 9:41 PM
Upon prolonged exposure, tolerant cells morph into a persistence status, where DNA repair is reduced. @daweonline.bsky.social using #scGETseq revealed that in persister cells chromatin became pervasively compacted with concomitant transcriptional reduction.
Blocking autophagy hampers this tolerant response increasing chemotherapy efficacy in various cancer types.
February 4, 2025 at 9:41 PM
Blocking autophagy hampers this tolerant response increasing chemotherapy efficacy in various cancer types.
Differing from #persistency, which occurs after long-term exposure to drugs, #tolerance is triggered immediately after anticancer treatment and provides a key survival advantage to cancer cells. This response is associated with increased DNA repair, driven by enhanced autophagy.
February 4, 2025 at 9:40 PM
Differing from #persistency, which occurs after long-term exposure to drugs, #tolerance is triggered immediately after anticancer treatment and provides a key survival advantage to cancer cells. This response is associated with increased DNA repair, driven by enhanced autophagy.