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GenomeTDCC
@genometdcc.org
470 followers 480 following 110 posts
Technology Development Coordinating Center at NHGRI. Advancing innovation in genomic technology development through collaboration, promoting standards, and outreach in conjunction with The Jackson Laboratory 🧬💻🧪
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genometdcc.org
SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬

Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing!

It's all there on the GenomeTDCC YouTube channel!
www.youtube.com/playlist?lis...
September 8, 2025 at 12:54 PM
genometdcc.org
📢Job Opening! 🧪🖥️🧬👩‍🔬
Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing.
Dr. Ya-Ming Hou at Thomas Jefferson University
houlaboratory.com/research

#HigherEd #EDUSky #AcademicSky #STS
August 4, 2025 at 2:28 PM
genometdcc.org
📅 June 9 - Genomic Technologies Open Science Day at @washu.bsky.social and online
www.jax.org/scienceday25

Register for Free by:
May 30: In-Person
June 8: Virtual

Learn how emerging tech is used to manipulate RNA & DNA, study genome function and structure, and navigate multi-omic analysis 🧪👩‍🔬🧬🖥️
Genomic Technologies Open Science Day on June 9. The event will be held at the Eric. P. Newman Education Center at Washington University in St. Louis and broadcast live online. Registration is free at https://www.jax.org/scienceday25/
May 28, 2025 at 3:24 PM
genometdcc.org
HAPPY DNA DAY! 🧬🧪
Genomics research has provided humanity with a transformative understand of life at the molecular level leading to a wide range of benefits in medical advancements, synthetic biology, biotechnology, infectious disease, agriculture, and evolution.
We are connected by ATGC
April 25, 2025 at 2:36 PM
genometdcc.org
From @nickingolia.bsky.social at @ucberkeleyofficial.bsky.social 🧪🧬🖥️
Disordered protein regions hold powerful sway over gene expression, as this new large-scale study reveals how they regulate mRNA stability and translation without a fixed structure. Published in @nature.com
doi.org/10.1038/s415...
Schematic of the fluorescence-based tethering assay as described in the recently published Nature paper by Joseph Lobel and Nick Ingolia, "Deciphering disordered regions controling mRNA decay in high-throughput".
April 24, 2025 at 12:52 PM
genometdcc.org
🚨PRE-PRINT 🧪🧬🖥️👩‍🔬
Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions
From Barak Cohen's lab at @washu.bsky.social

Read the pre-print 👇
doi.org/10.1101/2025...
Learn more about the research from the Cohen lab: bclab.wustl.edu
From the BioRxiv pre-print article "Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions" by Yawei Wu et al. Fig. 1. Design of long-range MPRA. a, Design of the enhancer landing pad and the promoter landing pad. The enhancer landing pad contains a dual promoter driving expression of an mTagBFP fluorescent protein and a thymidine kinase (TK) gene for counterselection, flanked by FRT and F3 sites for RMCE. available under aCC-BY-NC 4.0 International license. was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made bioRxiv preprint doi: https://doi.org/10.1101/2025.04.21.649048; this version posted April 22, 2025. The copyright holder for this preprint (which The promoter landing pad expresses the mEmerald fluorescent protein and iCaspase9 for counterselection and is flanked by loxFAS and loxP sites for orthogonal RMCE. b-c, Workflow of long-range MPRA. eBC: enhancer barcode; rBC: random barcode; dBC: distance barcode. A barcoded enhancer library is integrated into pooled long-range landing pad cells through Flpase-facilitated recombination. After counterselection with Ganciclovir, cells with successful integration are enriched. Cells are sorted into different bins based on mScarlet fluorescence level. Genomic DNA is extracted from each bin; barcodes are amplified and sequenced. Reporter gene expression of each enhancer at each distance is calculated as the weighted average of fluorescence levels across bins.
April 23, 2025 at 8:43 PM
genometdcc.org
📅 Genomic Technologies Open Science Day - June 9
FREE event featuring expert developers and users!
Register: www.jax.org/scienceday25/

Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social
🧪🧬🖥️👩‍🔬 #STS
Learn more at genometdcc.org#outreachevents
Free event with developers and users of genomic technologies. Register at https://www.jax.org/scienceday25/ The objective of this forum is to provide post-secondary students, postdoctoral associates/fellows and biomedical researchers with a fundamental understanding of how these new technologies are utilized, as well as emerging opportunities and challenges associated with their optimization and use.
April 23, 2025 at 3:29 PM
genometdcc.org
Single Cell Genomics Day! 🧪🧬🖥️
Friday April 25 (10:00 AM to 5:00 PM EDT)
Watch the event live satijalab.org/scgd25/
The Rahul Satija Lab at @nygenome.org and NYU is hosting the annual SINGLE-CELL GENOMICS DAY on #DNADay
Single Cell Genomics Day hosted by Rahul Satija. Happening on April 25, 2025
April 22, 2025 at 1:00 PM
genometdcc.org
DYK www.youtube.com/@genometdcc has videos on the latest genomic technology being developed by researchers supported by NHGRI? 👩‍🔬 🧪🧬🖥️ #STS
Highlighting new research pubs and #educational videos discussing innovations in synthetic biology, nucleic acid and protein seq, large-scale genomics, and more!
The Genome TDCC YouTube channel has several videos on the latest genomic technology being developed by researchers supported by NHGRI. Highlights on new research publications and educational videos discussing new developments from nucleic acid synthesis, protein sequencing, large-scale genomic analysis and more.
April 11, 2025 at 7:28 PM
genometdcc.org
FREE VIRTUAL SYMPOSIUM
Featuring experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. April 10 - 11
Register: tinyurl.com/43kkxvp7
Hosted by the Center for Genomic Information Encoded by RNA Nucleotide Modifications
🧬🧪🖥️ #STS #RNA
A two-day virtual symposium featuring global experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. Hosted by the NIH/NHGRI Center for Genomic Information Encoded by RNA Nucleotide Modifications
March 28, 2025 at 1:08 PM
genometdcc.org
Celebrate Pi day by embracing creativity, curiosity, and innovation (and 🥧)

Science, Technology, Engineering, and Mathematics make our world safer, united, and healthier. Explore the innovations being advanced from the NHGRI Genome Technology program at genometdcc.org 🧪🧬🖥️👩‍🔬 #STS
It's Pi Day! A time to honor the beauty of circles, the brilliance of 3.14159, and the joy of discovery. Let's celebrate with creativity, curiosity, and maybe even dessert.
March 14, 2025 at 2:34 PM
genometdcc.org
Everyday we're shuffling ... the genome.

Investigating hundreds to thousands of major structural variants throughout a mammalian genome with Genome-Shuffle-seq. From @jshendure.bsky.social et al. published in @science.org

👉 www.science.org/doi/full/10....
🧪 🧬 🖥️ #genesky
February 3, 2025 at 5:05 PM
genometdcc.org
We work w/ >90 NHGRI-funded investigators who are advancing the development of innovative #genomic technologies, nucleic acid #synthesis, and #sequencing technology development ( #RNA, #DNA, and #proteins ). 🧪🧬🖥️👩‍🔬
Fostering collaboration, innovation, and dissemination
genometdcc.org
Breakdown of the funded categories and key terms within the Genome Technology program grant portfolio including Small Business Innovation Research grants (R43/R44) and R21, R01 grants across 18 small businesses and >40 different research institutes
November 18, 2024 at 7:54 PM
genometdcc.org
Center for Genome Editing and Recording 🧬📼
Inaugural 5-day CRISPR training workshop for college-level instructors from HBCUs. Learn hands-on genome editing techniques to start new genome editing courses or incorporate into existing classes. 🧪👩‍🔬🖥️
Apply by Nov 30 👇
app.smartsheet.com/b/form/73546...
2025 CRISPR training workshop
October 29, 2024 at 3:42 PM
genometdcc.org
Kicking off the Annual CEGS meeting in La Jolla, CA. 🧪🧬🖥 👩‍🔬 #STS

Thank you to our hosts from the Center for Admixture Science and Technology w/ support from NHGRI, @jacksonlab.bsky.social

Learn more about the NHGRI-funded Centers of Excellence in Genomic Science at www.genome.gov/Funded-Progr...
Center of Excellence in Genomic Science annual meeting
October 28, 2024 at 4:56 PM
genometdcc.org
Hi BlueSky!
We work w/ NHGRI-funded investigators who are advancing the development of innovative genomic technologies, nucleic acid synthesis, and sequencing technology development (RNA/DNA and proteins). 🧪🧬🖥️👩‍🔬
Fostering collaboration, innovation, and dissemination
genometdcc.org
Breakdown of the NHGRI Genome Technology program grants and research areas that participate in the Technology Development Coordinating Center (TDCC).
October 22, 2024 at 2:23 PM
genometdcc.org
🧪🧬🖥️ 👩‍🔬
DYK @genometdcc.bsky.social collaborates with Genome Technology Developers, Innovators, and Expert Users? Our
YouTube showcases their work in sequencing, synthbio, and genomic tech. Check out the latest 📽️👇
youtube.com/@genometdcc
Supported by NHGRI in collaboration w @jacksonlab.bsky.social
The GenomeTDCC YouTube channel showcases videos from genomic technology developers, innovators, and expert users.
September 25, 2024 at 2:16 PM
genometdcc.org
Funding Biomedical Innovations for Non-Academic Entrepreneurs Webinar 🧪🧬🖥️👩‍🔬
Hosted by @XLerateHealth in collaboration w/ @NIH on 📅Tues, May 14 2PM-4PM EDT
Learn about SBIR/STTR funding and XLerateHealth's programs and resources.
To register, please visit bit.ly/3xHjbYY
Tuesday (5/14) from 2:00 PM to 4:00 PM EDT, a panel of NIH small business program representatives will discuss SBIR and STTR funding. This webinar is hosted by XLerateHealth in collaboration with more than a dozen NIH Institutes and Centers, to learn more about how non-academic biomedical entrepreneurs can jump start their business and develop their technology through funding at the National Institutes of Health. This event isn’t just for non-academic entrepreneurs – Discussion will include opportunities for non-academic entrepreneurs and academic innovators to collaborate on these federally funded initiatives. Attendees will learn about SBIR/STTR and other non-dilutive funding opportunities and commercialization resources for NIH applicants and awardees, as well as XLerateHealth’s entrepreneurial-focused programs and resources to support your journey! Presentations will be followed by a moderated Q&A session.
May 7, 2024 at 4:36 PM
genometdcc.org
Interested in learning more about Genome Technology development and use? 🧪🧬🖥️👩‍🔬#STS
Join us with @jaxeducation.bsky.social on June 10 for a FREE forum jax.org/gtf2024
Hear from leading developers and users!
Interactive Workshops with @epicypher and @AlidaBio
Meet with NHGRI SBIR-funded companies!
Promotional poster of the Genome Technology Forum. Being held in-person and online on June 10, 2024 from 9:30 AM to 5:30 PM Eastern Time. Free registration at https://www.jax.org/gtf2024
May 1, 2024 at 5:35 PM
genometdcc.org
Happy #DNADay! Today celebrates the discovery of DNA's double helix in 1953. Research and technology development in genomics continues to advance our understanding of who we are and the world around us.
Learn more about the work supported by NHGRI at www.genometdcc.org 🧪👩‍🔬🧬🖥️
DNA DAY 2024
April 25, 2024 at 5:13 PM
genometdcc.org
Join us for the Genome Technology Forum!
FREE Registration (hybrid event) jax.org/gtf2024

Fantastic lineup of speakers, interactive workshops with @Epicypher and @AlidaBiosciences, and more!
Mark your calendars 📅 June 10
🧪🧬🖥️👩‍⚕️#STS
In partnership with NHGRI and @jacksonlab.bsky.social
Don't miss this amazing opportunity to hear from industry leaders and genome technology developers and users. They will focus on emerging technologies for understanding human genome functions discussing multi-omic analyses at a single-cell level, genome structure and function, and large-scale analysis of nucleic acid-protein interactions. Speakers will also cover advances in technologies for making and sequencing DNA and RNA. Sign up for the in-person experiential learning sessions with EpiCypher and Alida Biosciences to learn about epigenetics and epitranscriptomics. Keynote lecture will be delivered by esteemed speaker Stacey Gabriel (Broad Institute of MIT and Harvard). Stick around for the National Human Genome Research Institute (NHGRI) Small Business Program Expo with Alida Biosciences, BacStitch DNA, Claret Bioscience, DNA Script, Electronic Biosciences, EpiCypher, Flexomics, Primrose Bio, Ribotherapeutics, and more! https://www.jax.org/gtf2024
April 17, 2024 at 3:42 PM
genometdcc.org
Single Cell Genomics Day
Today at 10AM ET
All talks streamed on Youtube and satijalab.org/scgd
🧪🧬🖥️
Advertisement for Single Cell Genomics Day live stream
March 29, 2024 at 12:42 PM
genometdcc.org
A PRINTER w/o an ink subscription!
An experimental + comp analysis framework for RBP-RNA interaction studies 👇
www.nature.com/articles/s41...

A collaborative effort between Gene Yeo, Rahul Kohli, and Alexis Komor. Funded in part by NHGRI Genome Tech Dev Opportunity Funds 🧪🧬🖥️#STS
A reporter system to assay RNA base editing activity of candidate RNA base editors (rBEs). a Reporter mRNA bearing twelve MS2 bacteriophage stemloops (yellowbars) downstreamof a Super folder GFP coding sequence (sfGFP) and a chimera bearing an MS2 coat-protein (MCP, black) domain fused to a candidate rBE (brown). b Strategy to test candidate rBEs. Plasmids encoding the constructs in a) are co-transfected into HEK293XT cells so that the MCP binds the MS2 stemloops in the reporter, and the rBE catalyzes RNA editing. After total RNA is isolated, targeted RNA sequencing is used to detect edits along the reporter sequence. (text from https://www.nature.com/articles/s41467-024-45009-4)
January 31, 2024 at 3:58 PM
genometdcc.org
A look into how RNA binding proteins govern alternative pre-mRNA splicing by enhancing exon inclusion with this recent publication in Nature Biotechnology. A collaborative effort from Marko Jovanovic (Columbia University) and Gene Yeo (UC San Diego)
🧪🖥️🧬
Check it out! 👇
doi.org/10.1038/s415...
Development of tethered function assays for detecting direct induction of exon inclusion. a, Schematic of luciferase reporters used in the assays and resulting isoforms after cellular mRNA processing. b, Analysis workflow for calculating percent-spliced-in from luminescence measurements. c, Splicing gels of lucMAPT-30D splicing in response to co-transfection with MCP-fused positive and negative controls. d, Bar graph of lucMAPT-30D reporter readout as calculated from the workflow in b with the same conditions as c. e, Experimental workflow of tethering assays. The effects of recruiting 718 MCP-fused RBPs are tested in both reporter contexts.
January 4, 2024 at 8:38 PM
genometdcc.org
Using whole-animal scRNAseq, Cole Trapnell, Michael Dorrity, and colleagues assess the role of proteostasis - maintenance of proper protein synthesis, folding, and degradation during zebrafish development at increased temperatures 🖥️🧬🧪🐟
doi.org/10.1016/j.ce...
Embryo-wide profiling of transcription, timing, and cell composition in zebrafish reveals processes that limit development robustness under increasing temperatures.
November 14, 2023 at 9:18 PM