@genikhovich.bsky.social
Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼
Congratulations to Dr. Paul Knabl @paulknabl.bsky.social Fantastic work and excellent defense!
September 11, 2025 at 6:02 PM
Congratulations to Dr. Paul Knabl @paulknabl.bsky.social Fantastic work and excellent defense!
By generating local sources of either diffusible or membrane-tethered Chordin in the Chordin morphant background, David showed that mobility of Chordin is necessary and sufficient to generate a peak of BMP signaling opposite to the Chordin production site.
June 13, 2025 at 8:35 PM
By generating local sources of either diffusible or membrane-tethered Chordin in the Chordin morphant background, David showed that mobility of Chordin is necessary and sufficient to generate a peak of BMP signaling opposite to the Chordin production site.
And June showed that this is bang in the middle of the pSMAD1/5 gradient! So, even if an animal has a CNS, BMP signaling is not "anti-neural". It is just "anti-ventral" (or, in case of chordates, "anti-dorsal").
BTW, early Spadella embryo has a beautiful ventral chordin and dorsal bmp2/4 - look:
BTW, early Spadella embryo has a beautiful ventral chordin and dorsal bmp2/4 - look:
June 9, 2025 at 8:57 AM
And June showed that this is bang in the middle of the pSMAD1/5 gradient! So, even if an animal has a CNS, BMP signaling is not "anti-neural". It is just "anti-ventral" (or, in case of chordates, "anti-dorsal").
BTW, early Spadella embryo has a beautiful ventral chordin and dorsal bmp2/4 - look:
BTW, early Spadella embryo has a beautiful ventral chordin and dorsal bmp2/4 - look:
... to repression of the neural genes. This shows us that BMP has a pro-neural role both in anthozoan and medusozoan cnidarians. Here, for example, is BMP activity in the ring nerve of the Tripedalia medusa bell.
June 9, 2025 at 8:57 AM
... to repression of the neural genes. This shows us that BMP has a pro-neural role both in anthozoan and medusozoan cnidarians. Here, for example, is BMP activity in the ring nerve of the Tripedalia medusa bell.
This is what is currently missing: GFP fluorescence of the GFP-beta-catenin knock-in embryos showing maternal GFP-b-cat in the vegetal half of the embryo and the onset of gastrulation at the animal pole.
March 13, 2025 at 11:26 AM
This is what is currently missing: GFP fluorescence of the GFP-beta-catenin knock-in embryos showing maternal GFP-b-cat in the vegetal half of the embryo and the onset of gastrulation at the animal pole.