Genes & Diseases Journal
@genesndiseases.bsky.social
International Open Access journal publishing on molecular and translational medicine. IF 2024,9.4; Scopus Citescore 2024, 8.4.
This review outlines how #ferroptosis—driven by #GPX4 regulation, #IronMetabolism, and #LipidPeroxidation—offers a strategy to reverse #DrugResistance in digestive system #cancers, highlighting emerging ferroptosis-inducing therapeutic approaches.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 9, 2025 at 1:25 AM
This review outlines how #ferroptosis—driven by #GPX4 regulation, #IronMetabolism, and #LipidPeroxidation—offers a strategy to reverse #DrugResistance in digestive system #cancers, highlighting emerging ferroptosis-inducing therapeutic approaches.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
SET–PP2A axis driven increased levels of both H2AX and γH2AX in #Glioma #StemCells (GSCs) maintain GSC self-renewal and #Tumorigenic capacity, highlighting it as a potential #TherapeuticTarget to disrupt GSC-driven #Tumor growth. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 8, 2025 at 4:34 PM
SET–PP2A axis driven increased levels of both H2AX and γH2AX in #Glioma #StemCells (GSCs) maintain GSC self-renewal and #Tumorigenic capacity, highlighting it as a potential #TherapeuticTarget to disrupt GSC-driven #Tumor growth. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
From stem cells and biomaterials to gene-based therapies and lab-grown tissues, the future of medicine may soon be about renewal rather than replacement.
We invite you to submit your research to Genes & Diseases here: www.editorialmanager.com/gendis/
#RegenerativeMedicine
We invite you to submit your research to Genes & Diseases here: www.editorialmanager.com/gendis/
#RegenerativeMedicine
December 8, 2025 at 3:38 PM
From stem cells and biomaterials to gene-based therapies and lab-grown tissues, the future of medicine may soon be about renewal rather than replacement.
We invite you to submit your research to Genes & Diseases here: www.editorialmanager.com/gendis/
#RegenerativeMedicine
We invite you to submit your research to Genes & Diseases here: www.editorialmanager.com/gendis/
#RegenerativeMedicine
This research reveals how SIRT5 can enhance the bone-forming effects of BMP9 by protecting HIF-1α from degradation in mouse embryonic fibroblasts suggesting a novel regulatory axis for improving osteogenesis.
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:38 PM
This research reveals how SIRT5 can enhance the bone-forming effects of BMP9 by protecting HIF-1α from degradation in mouse embryonic fibroblasts suggesting a novel regulatory axis for improving osteogenesis.
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
#BoneRegeneration #RegenerativeMedicine #SIRT5
www.sciencedirect.com/science/arti...
This work explores how m6A RNA methylation regulates embryonic stem cell (ESC) maintenance & differentiation — shedding light on epitranscriptomic mechanisms that influence pluripotency and cell fate.
#m6A #Epigenetics #StemCells #ESCs #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#m6A #Epigenetics #StemCells #ESCs #RegenerativeMedicine
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:36 PM
This work explores how m6A RNA methylation regulates embryonic stem cell (ESC) maintenance & differentiation — shedding light on epitranscriptomic mechanisms that influence pluripotency and cell fate.
#m6A #Epigenetics #StemCells #ESCs #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#m6A #Epigenetics #StemCells #ESCs #RegenerativeMedicine
www.sciencedirect.com/science/arti...
This comprehensive piece explores how Wnt signaling regulates stem-cell behavior, influences disease processes, and opens new avenues for therapies.
#Wnt #StemCells #DevelopmentalBiology #RegenerativeMedicine #Therapeutics
www.sciencedirect.com/science/arti...
#Wnt #StemCells #DevelopmentalBiology #RegenerativeMedicine #Therapeutics
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:36 PM
This comprehensive piece explores how Wnt signaling regulates stem-cell behavior, influences disease processes, and opens new avenues for therapies.
#Wnt #StemCells #DevelopmentalBiology #RegenerativeMedicine #Therapeutics
www.sciencedirect.com/science/arti...
#Wnt #StemCells #DevelopmentalBiology #RegenerativeMedicine #Therapeutics
www.sciencedirect.com/science/arti...
This research reports promising preclinical data showing that autologous HSCs + IL2RG gene therapy may offer an effective route to treating X-linked SCID.
#GeneTherapy #StemCells #SCID #Immunology #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#GeneTherapy #StemCells #SCID #Immunology #RegenerativeMedicine
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:35 PM
This research reports promising preclinical data showing that autologous HSCs + IL2RG gene therapy may offer an effective route to treating X-linked SCID.
#GeneTherapy #StemCells #SCID #Immunology #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#GeneTherapy #StemCells #SCID #Immunology #RegenerativeMedicine
www.sciencedirect.com/science/arti...
This research examines how the microenvironment & cellular behavior influence the paracrine signaling of stem cells — a vital mechanism by which stem cells support regeneration & tissue repair. #StemCells #ParacrineSignaling #RegenerativeMedicine #CellTherapy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:35 PM
This research examines how the microenvironment & cellular behavior influence the paracrine signaling of stem cells — a vital mechanism by which stem cells support regeneration & tissue repair. #StemCells #ParacrineSignaling #RegenerativeMedicine #CellTherapy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
This paper investigates how pre-existing cardiomyocytes may act as central players in regenerative signaling, offering fresh perspectives on how the heart could repair itself after injury. #CardiacRegeneration #Cardiomyocytes #RegenerativeMedicine
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:34 PM
This paper investigates how pre-existing cardiomyocytes may act as central players in regenerative signaling, offering fresh perspectives on how the heart could repair itself after injury. #CardiacRegeneration #Cardiomyocytes #RegenerativeMedicine
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Uncovering how BMP9 influences cell proliferation & the integrity of intercellular junctions in Hertwig’s Epithelial Root Sheath (HERS) — shedding light on molecular mechanisms underlying tooth root formation & development.
#Dentinogenesis #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#Dentinogenesis #RegenerativeMedicine
www.sciencedirect.com/science/arti...
December 8, 2025 at 3:33 PM
Uncovering how BMP9 influences cell proliferation & the integrity of intercellular junctions in Hertwig’s Epithelial Root Sheath (HERS) — shedding light on molecular mechanisms underlying tooth root formation & development.
#Dentinogenesis #RegenerativeMedicine
www.sciencedirect.com/science/arti...
#Dentinogenesis #RegenerativeMedicine
www.sciencedirect.com/science/arti...
This paper explores how extracellular vesicles from oral mesenchymal stem cells influence tissue homeostasis, regeneration, and disease — highlighting their therapeutic potential for oral health, bone repair, immunomodulation and beyond.
#OraltissueMSC #Tissueregeneration
doi.org/10.1016/j.ge...
#OraltissueMSC #Tissueregeneration
doi.org/10.1016/j.ge...
December 8, 2025 at 3:32 PM
This paper explores how extracellular vesicles from oral mesenchymal stem cells influence tissue homeostasis, regeneration, and disease — highlighting their therapeutic potential for oral health, bone repair, immunomodulation and beyond.
#OraltissueMSC #Tissueregeneration
doi.org/10.1016/j.ge...
#OraltissueMSC #Tissueregeneration
doi.org/10.1016/j.ge...
Insights from regenerative medicine a field with the potential to transform how we treat injury, disease & organ failure.
Here is a selection of recent findings published in Genes & Diseases and what they could mean for patients, clinicians and researchers.
www.keaipublishing.com/en/journals/...
Here is a selection of recent findings published in Genes & Diseases and what they could mean for patients, clinicians and researchers.
www.keaipublishing.com/en/journals/...
December 8, 2025 at 3:31 PM
Insights from regenerative medicine a field with the potential to transform how we treat injury, disease & organ failure.
Here is a selection of recent findings published in Genes & Diseases and what they could mean for patients, clinicians and researchers.
www.keaipublishing.com/en/journals/...
Here is a selection of recent findings published in Genes & Diseases and what they could mean for patients, clinicians and researchers.
www.keaipublishing.com/en/journals/...
#CXCR4, highly expressed in #aldosterone-producing #adenomas, co-localizes with #CYP11B2 & suppresses aldosterone synthesis by inhibiting CYP11B2 transcription, suggesting CXCR4 acts as a compensatory regulator in aldosterone-producing lesions.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 8, 2025 at 12:49 PM
#CXCR4, highly expressed in #aldosterone-producing #adenomas, co-localizes with #CYP11B2 & suppresses aldosterone synthesis by inhibiting CYP11B2 transcription, suggesting CXCR4 acts as a compensatory regulator in aldosterone-producing lesions.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the role of peripheral nerves in #SolidTumors, with insights into the prevalence & clinical impact of nerve–tumor interactions, their underlying mechanisms, research advancements and therapeutic potential. @pku1898.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 8, 2025 at 2:56 AM
Reviewing the role of peripheral nerves in #SolidTumors, with insights into the prevalence & clinical impact of nerve–tumor interactions, their underlying mechanisms, research advancements and therapeutic potential. @pku1898.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Obesity-associated fibroblasts reshape the #TME across #cancers, identify the TS.FIBRO.OBESITY.SIG signature linked to #ECM remodeling, #ImmuneSuppression and #TherapyResistance, and highlight key genes that may guide prognosis and treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 4:34 PM
Obesity-associated fibroblasts reshape the #TME across #cancers, identify the TS.FIBRO.OBESITY.SIG signature linked to #ECM remodeling, #ImmuneSuppression and #TherapyResistance, and highlight key genes that may guide prognosis and treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 12:49 PM
IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review explores the action mechanism of PARPi, the mechanisms underlying #PARPi resistance in cancers, and summarizes the strategies to overcome PARPi resistance, to extend PARPi applications and improve patient outcomes. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 7, 2025 at 2:56 AM
This review explores the action mechanism of PARPi, the mechanisms underlying #PARPi resistance in cancers, and summarizes the strategies to overcome PARPi resistance, to extend PARPi applications and improve patient outcomes. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review examines #GPR126's expression, #ligandreceptor interactions, signaling, and roles in development/diseases, highlighting small molecule, #peptide, and #monobody modulators as promising #aGPCRs-targeted therapies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 5:25 PM
This review examines #GPR126's expression, #ligandreceptor interactions, signaling, and roles in development/diseases, highlighting small molecule, #peptide, and #monobody modulators as promising #aGPCRs-targeted therapies.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the tissue distribution, transfection rates and #Immunogenicity of recombinant adeno-associated virus serotype 8 (#AAV8) in gene therapy, with insights into the applications and challenges of using AAV8 as a vector.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 12:25 PM
Reviewing the tissue distribution, transfection rates and #Immunogenicity of recombinant adeno-associated virus serotype 8 (#AAV8) in gene therapy, with insights into the applications and challenges of using AAV8 as a vector.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights #CRISPRCas9 as a precise #GeneEditing tool with therapeutic applications across #cancers, and acquired diseases, discussing #ClinicalTrials, off‑target challenges, and advances in #viral and #NonViralDelivery systems.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 6, 2025 at 1:25 AM
This review highlights #CRISPRCas9 as a precise #GeneEditing tool with therapeutic applications across #cancers, and acquired diseases, discussing #ClinicalTrials, off‑target challenges, and advances in #viral and #NonViralDelivery systems.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 4:34 PM
A review on m6A methylation regulation & its biological functions in the #ImmuneSystem, detailing its critical role in the #Pathogenesis of #AutoimmuneDiseases, identifying potential #Biomarkers & targets for their prevention & treatment.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Researchers elucidate how #Hypoxiainduciblefactor1α drives #tumor progression in solid and hematological malignancies by regulating proliferation, #angiogenesis, metabolism, immunity, and therapy resistance in #hypoxic #microenvironments.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 12:59 PM
Researchers elucidate how #Hypoxiainduciblefactor1α drives #tumor progression in solid and hematological malignancies by regulating proliferation, #angiogenesis, metabolism, immunity, and therapy resistance in #hypoxic #microenvironments.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review explains how tumor cell heterogeneity, including resistant and tolerant subpopulations and quiescent states, drives #TherapyAdaptation and cancer survival, highlighting mechanisms that may help prevent recurrence. #cancer #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 6:14 AM
This review explains how tumor cell heterogeneity, including resistant and tolerant subpopulations and quiescent states, drives #TherapyAdaptation and cancer survival, highlighting mechanisms that may help prevent recurrence. #cancer #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
Reviewing the structure, regulation, and function of RRM2 and its inhibitors, its critical role in promoting tumor malignancy, #TumorImmunity, #TherapyResistance & the #TumorMicroenvironment, with insights into RRM2-targeted therapies. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 5, 2025 at 2:55 AM
Reviewing the structure, regulation, and function of RRM2 and its inhibitors, its critical role in promoting tumor malignancy, #TumorImmunity, #TherapyResistance & the #TumorMicroenvironment, with insights into RRM2-targeted therapies. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights the CD47‑SIRPα axis as a key #ImmuneCheckpoint in #lymphoma, detailing current therapeutic strategies, including #FcFusionProteins and #peptides, and underscores their potential in treating Hodgkin and #NonHodgkinlymphomas.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 4, 2025 at 5:25 PM
This review highlights the CD47‑SIRPα axis as a key #ImmuneCheckpoint in #lymphoma, detailing current therapeutic strategies, including #FcFusionProteins and #peptides, and underscores their potential in treating Hodgkin and #NonHodgkinlymphomas.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...