Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds that poor nuclease processing and selective TLR avoidance drive this evasion, offering insight into the molecular basis of immune tolerance to pseudouridine-containing RNA.

Background For decades, vast stretches of the genome were dismissed as non-functional ‘junk’. However, our group and others have revealed that these regions harbor numerous non-canonical open reading ...

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Eizellen können mehrere Jahrzehnte alt werden und verfügen auch sonst über Tricks, die sie von allen anderen Zellen im Körper abheben. Vieles bleibt dennoch unverstanden

Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.

Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.

Nanopore direct RNA sequencing (DRS) enables direct measurement of RNA molecules, including their native RNA modifications, without prior conversion to cDNA. However, commercial methods for molecular ...