Garett Dunsmore
@garett-dunsmore.bsky.social
Canadian Immunologist in Paris France working in the laboratory of Florent Ginhoux
Reposted by Garett Dunsmore
Congrats @lozanzi.bsky.social and team on this absolute tour-de-force study www.cell.com/cell/abstrac... showing that type III-IFN and ZBP1-dependent casp8 activation leads to GSDMC cleavage and pyroptosis in IECs that delays intestinal epithelial repair during colitis or irradiation‼️💪🏼🤯
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 27, 2024 at 1:22 AM
Congrats @lozanzi.bsky.social and team on this absolute tour-de-force study www.cell.com/cell/abstrac... showing that type III-IFN and ZBP1-dependent casp8 activation leads to GSDMC cleavage and pyroptosis in IECs that delays intestinal epithelial repair during colitis or irradiation‼️💪🏼🤯