This research by GALENOS was influenced by the lived experience of our GLEAB members.

They ensured that the research on pro-dopaminergic drugs was impact focused.

You can learn more in this interview with GLEAB member Judy: www.galenos.org.uk/blog-news/wh...
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GALENOS researchers have found that dopamine is implicated in anhedonia, and shared their findings in a new paper published in @ebiomedicine.bsky.social

Other neurotransmitters are involved as well and more research is needed to fully understand the complex causes of anhedonia.

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GALENOS is investigating the effects of estrogen-based treatments in adults with SSD by compiling the existing evidence into one big systematic review.

You can read more about this project, and view the evidence yourself, here: www.galenos.org.uk/blog-news/es...

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Postmenopausal women have estrogen levels that are comparable to mens.

Reduced estrogen levels in women have been linked to worsening symptoms of SSD during hormonally sensitive periods such as menstruation, after childbirth (postpartum), and during menopause.
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Estrogen is a hormone that supports growth, heart health & reproduction.

Women have higher levels because it’s key for female reproductive functions.

Men make smaller amounts & rely more on testosterone for development.
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Men typically experience an earlier onset, often in their late teens or early twenties, while women tend to develop symptoms later in life, frequently around menopause.

These observations prompted researchers to explore if increased levels of estrogen could stabilize symptoms of SSD.

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"In complex projects like GALENOS that face the challenge of how to deliver meaningful lived experience engagement, we must get used to discomfort. If you're experiencing this, it likely indicates that you're on the right path."
- Emily Wheeler

#bna2025

www.galenos.org.uk/blog-news/re...

Find out more about how the GALENOS project champions co-production here: www.galenos.org.uk