Gillian Fraser
@fraserlabcam.bsky.social
Molecular Microbiologist in Cambridge, UK.
🦠🧫🧬
🦠🧫🧬
Reposted by Gillian Fraser
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted by Gillian Fraser
In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation | PNAS www.pnas.org/doi/10.1073/...
In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation | PNAS
The Dot/Icm machine of Legionella pneumophila is among the most versatile type IV
secretion systems (T4SSs), capable of translocating more than 330...
www.pnas.org
November 7, 2025 at 5:48 PM
In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation | PNAS www.pnas.org/doi/10.1073/...
Reposted by Gillian Fraser
More useful with the link #microsky www.biorxiv.org/content/10.1...
November 6, 2025 at 3:57 PM
More useful with the link #microsky www.biorxiv.org/content/10.1...
Reposted by Gillian Fraser
Important report critiquing how uk has been or not been supporting scaling up science innovations. Notably also scathing about vast costs for visas for researchers too- hope this will be noted and acted upon🧪
U.K. science sector is ‘bleeding to death,’ lawmakers say in report
House of Lords committee urges government to stem exodus of science and technology companies
www.science.org
November 6, 2025 at 8:12 AM
Important report critiquing how uk has been or not been supporting scaling up science innovations. Notably also scathing about vast costs for visas for researchers too- hope this will be noted and acted upon🧪
Reposted by Gillian Fraser
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
November 4, 2025 at 5:20 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Gillian Fraser
Looking for a PhD opportunity in Microbiology? Consider joining one of the UK's leading microbiology research clusters at Newcastle University. See the thread for MRC DTP studentships currently advertised. @medicalsciencesncl.bsky.social @sagencl.bsky.social @cbcb-newcastle.bsky.social #microsky
November 4, 2025 at 10:54 AM
Looking for a PhD opportunity in Microbiology? Consider joining one of the UK's leading microbiology research clusters at Newcastle University. See the thread for MRC DTP studentships currently advertised. @medicalsciencesncl.bsky.social @sagencl.bsky.social @cbcb-newcastle.bsky.social #microsky
Reposted by Gillian Fraser
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Clostridial Cell Biology Group
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells...
sites.google.com
October 31, 2025 at 3:44 PM
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Reposted by Gillian Fraser
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Want to find ways to combat TB? Check out this PhD position 👇
Reposted by Gillian Fraser
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
www.findaphd.com
November 2, 2025 at 8:22 PM
If you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
Reposted by Gillian Fraser
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh on FindAPhD.com
PhD Project - Investigating the role of the Vi antigen in Salmonella pathogenesis. at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 2, 2025 at 6:07 PM
If you’re interested in solving bacterial mysteries, this PhD project is for you!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Gillian Fraser
Beautiful work using #insitu #cryoEM #SingleParticleAnalysis from @guowangbiao @yalemed.bsky.social in @natmicrobiol.nature.com www.nature.com/articles/s41...
October 31, 2025 at 6:07 PM
Beautiful work using #insitu #cryoEM #SingleParticleAnalysis from @guowangbiao @yalemed.bsky.social in @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by Gillian Fraser
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
October 28, 2025 at 8:43 AM
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
Reposted by Gillian Fraser
We are looking for mentors for the Sci.STEPS program! Please apply if you want to help your junior colleagues around the globe navigate their career path in any science related field.
🤩Join the Sci.STEPS 2026 Mentor Cohort!
We invite #mentors from varied backgrounds and stages of their #scientific careers to apply and share their knowledge and expertise with our #mentees.
✏ Register here: lnkd.in/edZggY32
🗓 Deadline: November 10th 2025
👀more about #SciSTEPS: www.scisteps.org
We invite #mentors from varied backgrounds and stages of their #scientific careers to apply and share their knowledge and expertise with our #mentees.
✏ Register here: lnkd.in/edZggY32
🗓 Deadline: November 10th 2025
👀more about #SciSTEPS: www.scisteps.org
October 24, 2025 at 12:22 PM
We are looking for mentors for the Sci.STEPS program! Please apply if you want to help your junior colleagues around the globe navigate their career path in any science related field.
Reposted by Gillian Fraser
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications
Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...
www.nature.com
October 24, 2025 at 4:08 AM
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
Reposted by Gillian Fraser
Pls share: Secchi group at ETH Zürich is recruiting two fully funded, four-year PhD positions for an SNSF-funded project investigating the nonlinear rheology of bacterial biofilms. Deadline: 30 November 2025. Full advert and submission details: jobs.ethz.ch/job/view/JOP...
Two PhD positions in Biophysics and rheology of bacterial biofilms
jobs.ethz.ch
October 21, 2025 at 10:39 AM
Pls share: Secchi group at ETH Zürich is recruiting two fully funded, four-year PhD positions for an SNSF-funded project investigating the nonlinear rheology of bacterial biofilms. Deadline: 30 November 2025. Full advert and submission details: jobs.ethz.ch/job/view/JOP...
Reposted by Gillian Fraser
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
October 17, 2025 at 12:47 PM
Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?
Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria.
doi.org/10.1101/2025...
Reposted by Gillian Fraser
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
October 15, 2025 at 6:26 AM
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
Reposted by Gillian Fraser
My colleagues & I have taken a huge gamble to set up @thenerve.news We’re trying to build a new independent publication from the ground up. Social media is our only distribution for now.
Sharing this article in your networks would make a huge difference. Thank you! 🙏🙏🙏
Sharing this article in your networks would make a huge difference. Thank you! 🙏🙏🙏
NEW: The British politician, his Russian intelligence handler & a Kremlin plot against the US & Ukraine.
My new piece about Nathan Gill and Nigel Farage for @thenerve_news in which we ask:
Why, even now, is no-one asking questions?
t.co/BUTtpK9C4S
My new piece about Nathan Gill and Nigel Farage for @thenerve_news in which we ask:
Why, even now, is no-one asking questions?
t.co/BUTtpK9C4S
October 13, 2025 at 9:21 AM
My colleagues & I have taken a huge gamble to set up @thenerve.news We’re trying to build a new independent publication from the ground up. Social media is our only distribution for now.
Sharing this article in your networks would make a huge difference. Thank you! 🙏🙏🙏
Sharing this article in your networks would make a huge difference. Thank you! 🙏🙏🙏
Reposted by Gillian Fraser
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership
Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.
biodtp.norwichresearchpark.ac.uk
October 13, 2025 at 6:46 AM
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Reposted by Gillian Fraser
Type IV secretion systems: from structures to mechanisms
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
October 9, 2025 at 10:44 AM
Type IV secretion systems: from structures to mechanisms
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems
www.embopress.org/doi/full/10....
Reposted by Gillian Fraser
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
www.findaphd.com/phds/?Keywor...
www.findaphd.com/phds/?Keywor...
grainger birmingham PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
October 7, 2025 at 3:53 PM
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
www.findaphd.com/phds/?Keywor...
www.findaphd.com/phds/?Keywor...
Reposted by Gillian Fraser
2012 Nobel laureate John Gurdon has died. His work was central to both the development of animal cloning and the possibility of reprogramming cells to a different state. A giant of cell and developmental biology.
www.magd.cam.ac.uk/news/profess...
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 3:51 PM
2012 Nobel laureate John Gurdon has died. His work was central to both the development of animal cloning and the possibility of reprogramming cells to a different state. A giant of cell and developmental biology.
www.magd.cam.ac.uk/news/profess...
www.magd.cam.ac.uk/news/profess...
Reposted by Gillian Fraser
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
October 6, 2025 at 4:46 PM
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gillian Fraser
This is incredibly beautiful, and the fact that the resolution is sufficient to follow the path of DNA spooling inside the virion head and through the tail is amazing
Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 6, 2025 at 11:41 AM
This is incredibly beautiful, and the fact that the resolution is sufficient to follow the path of DNA spooling inside the virion head and through the tail is amazing
Reposted by Gillian Fraser
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!