#Metformin dosing was:
500 mg on day 1,
500 mg twice daily on days 2–5,
500 mg in the morning and 1000 mg in the evening on days 6–14.
academic.oup.com/cid/article/...
(#Fluvoxamine dosing was: 50 mg on day 1 and 50 mg twice daily on days 2–14. Didn't work with that dose).

Thanks about the warning.
How much Lithium Orotate was your son taking and for how long? How low kidney function did he have?

Also people on a low-sodium diet should take less lithium, because kidneys extract less lithium when they don't have to extract excess sodium.

1000mcg = 1mg/day of #Lithium #Orotate is enough for most people.
iherb.com/pr/life-exte...
0.5mg might be enough for those on low-sodium diet?
Kidneys can't tell the difference between Na+ and Li+?

Does food affect #bioavailability of LiO?
#LithiumOrotate #Alzheimer #Alzheimers #nootropic #Litium

Were they able to mix lithium orotate in distilled drinking water for mice? Without constantly stirring?
onlinelibrary.wiley.com/doi/10.1002/...
"Mineral orotates display limited Dissociation in biological solutions, allowing them to exist in sera as non-dissociated, Electrically Neutral compounds"

Aron et al present compelling evidence that #lithium does in fact have a physiological role, and that Normal Ageing might impair the regulation of lithium levels in the brain.
For example, Li+ could be a signalling ion similar to #copper (Cu+), which has a signalling role at trace concentrations.

Normal Ageing is associated with loss of neuronal architecture, reflected by a decline in learning and memory. Remarkably, lithium orotate prevented these effects in Wild-Type Mice.
www.nature.com/articles/d41...

Not only for Alzheimer's, Every adult human should take 1mg/day Lithium Orotate?

Li salts were dissolved in distilled, deionized drinking water and administered ad libitum to mice. The low Li dose corresponded to equivalent to 0.03 mg (30  µg) of elemental Li per litre.
www.nature.com/articles/s41...
Mice drink between 3 and 9 milliliters of water/day!
Daily dose is 0.006*0.03mg

1mg/day #lithium is more than enough.
Open 5mg capsule, eat 20%.
All #LithiumOrotate capsules & tablets were approved:
Vital Nutrients, Weyland, Swanson, Pure Encapsulations, @lifeextension.bsky.social, KAL, Advanced Research.
www.consumerlab.com/reviews/lith...

Mice got lithium #orotate from water

It has a different #adjuvant.
Novavax Nuvaxovid covid vaccine has Matrix-M adjuvant.
Arexvy RSV vaccine has AS01E adjuvant, 25µg/dose. Given as 1 dose (1-3 years interval if boosted for more winter seasons).
SHINGrix SHINGles shot has AS01B adjuvant, 50µg/dose. Given as 2 doses, 2-6 months interval.

"Second, we did not investigate the impact of several #doses of the vaccine".
www.nature.com/articles/s41...
"Saturation effect could explain why the level of protection against #dementia appears similar between the #AS01 shingles vaccine (that is given in 2 doses) and the AS01 #RSV vaccine (1 dose)

CDC recommends 2 doses of Shingrix separated by 2-6 months for adults >=50 years. In many countries (for example here in Finland) 2 months interval is preferred (why?), but can be extended upto 6 months if necessary.

1 dose of Arexvy RSV = 25µg AS01 adjuvant
1 dose of Shingrix = 50µg AS01
2 doses of Shingrix worked as well as 1 dose of Arexvy!
It might be that neuroprotective mechanisms reach their full potential at OR below the dose of AS01 administered within a single vaccine!
How often to REDOSE with AS01??

That's not surprising because some senescent cells have beneficial functions (e.g. anti-cancer) and there's no easy way to target the bad ones
www.sciencedirect.com/science/arti...

To avoid sub/supra-therapeutic level, why not begin measuring cyclosporine level 0 days after course completion, instead of 2 days? Otherwise the protocol is good.
At the first follow-up 2 days after completion:
20% subtherapeutic and 31% supratherapeutic.
Subtherapeutic is more dangerous than supra

Here are the influenza cases for Australia, by year since 2010. 2025 will be the 4th huge year in a row - wildly unprecedented.

It's increasingly hard to not draw the conclusion that something broke from 2022 onwards. Immune systems?
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