Flávia E. Rius
@flaviaerius.bsky.social
I work with Polygenic Risk Scores for Brazilians @ Mendelics
#rstats #bioinformatics
#rstats #bioinformatics
Tip for formatting text on Google Docs by Gemini *without changing content*:
If the text is in one language, use the prompt to format in another language. It worked perfectly for me!
Before that, every time I asked it to "format without changing text" it failed.
#gemini
If the text is in one language, use the prompt to format in another language. It worked perfectly for me!
Before that, every time I asked it to "format without changing text" it failed.
#gemini
November 11, 2025 at 1:44 PM
Tip for formatting text on Google Docs by Gemini *without changing content*:
If the text is in one language, use the prompt to format in another language. It worked perfectly for me!
Before that, every time I asked it to "format without changing text" it failed.
#gemini
If the text is in one language, use the prompt to format in another language. It worked perfectly for me!
Before that, every time I asked it to "format without changing text" it failed.
#gemini
Reposted by Flávia E. Rius
🧬 PRSs in practice (3/5): Higher-risk results = behaviour change?
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
November 6, 2025 at 2:27 PM
🧬 PRSs in practice (3/5): Higher-risk results = behaviour change?
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
A common concern is that higher-risk polygenic risk scores (PRSs) don’t motivate lifestyle behaviour change.
My @nathumbehav.nature.com paper with @mikeinouye.bsky.social addresses this 👉 rdcu.be/eNeKN
#Genomics #BehaviourChange
So interesting!
Highest SNP heritabilities (which mean variation explained by genetics) after controlling for parent education and birthplace were around 10% for social sciences and journalism, for arts and humanities, and for natural sciences, mathematics and statistics.
Highest SNP heritabilities (which mean variation explained by genetics) after controlling for parent education and birthplace were around 10% for social sciences and journalism, for arts and humanities, and for natural sciences, mathematics and statistics.
1/ 🚨New paper in Nature Genetics
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic factors are associated with the educational fields people study, from arts to engineering.
Article: www.nature.com/articles/s41...
FAQ: www.thehastingscenter.org/genomic-find...
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
www.nature.com
November 4, 2025 at 2:40 PM
So interesting!
Highest SNP heritabilities (which mean variation explained by genetics) after controlling for parent education and birthplace were around 10% for social sciences and journalism, for arts and humanities, and for natural sciences, mathematics and statistics.
Highest SNP heritabilities (which mean variation explained by genetics) after controlling for parent education and birthplace were around 10% for social sciences and journalism, for arts and humanities, and for natural sciences, mathematics and statistics.
About PRSs in the clinics: people do not understand risk in general, not only the risk related to PRS.
The solution is educating health professionals to communicate PRS risk (and other risks) clearly.
The solution is educating health professionals to communicate PRS risk (and other risks) clearly.
🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
November 3, 2025 at 5:49 PM
About PRSs in the clinics: people do not understand risk in general, not only the risk related to PRS.
The solution is educating health professionals to communicate PRS risk (and other risks) clearly.
The solution is educating health professionals to communicate PRS risk (and other risks) clearly.
Reposted by Flávia E. Rius
4 word horror story for an R user:
"has a Java dependency"
"has a Java dependency"
October 12, 2025 at 4:29 PM
4 word horror story for an R user:
"has a Java dependency"
"has a Java dependency"
Probably late, but his week I finally understood the meaning of prompt engineering.
I used a prompt, extracted results, measured them, then adjusted both the input and prompt for better results, measured them, adjusted inputs again, measured results, and finally applied to a new dataset.
I used a prompt, extracted results, measured them, then adjusted both the input and prompt for better results, measured them, adjusted inputs again, measured results, and finally applied to a new dataset.
October 11, 2025 at 12:19 AM
Probably late, but his week I finally understood the meaning of prompt engineering.
I used a prompt, extracted results, measured them, then adjusted both the input and prompt for better results, measured them, adjusted inputs again, measured results, and finally applied to a new dataset.
I used a prompt, extracted results, measured them, then adjusted both the input and prompt for better results, measured them, adjusted inputs again, measured results, and finally applied to a new dataset.
Reposted by Flávia E. Rius
Ever wondered why analyzing RNA-seq data feels like walking through a fog with 20,000 dimensions?
Let’s talk about the curse of dimensionality in bioinformatics—and why it’s not just a math problem, it’s a biological one. 🧵
Let’s talk about the curse of dimensionality in bioinformatics—and why it’s not just a math problem, it’s a biological one. 🧵
October 9, 2025 at 1:15 PM
Ever wondered why analyzing RNA-seq data feels like walking through a fog with 20,000 dimensions?
Let’s talk about the curse of dimensionality in bioinformatics—and why it’s not just a math problem, it’s a biological one. 🧵
Let’s talk about the curse of dimensionality in bioinformatics—and why it’s not just a math problem, it’s a biological one. 🧵
I just want to share that I had a blast at #positconf2025! Met so many wonderful people, and gave a talk for the first time. It was awesome!
September 27, 2025 at 4:28 PM
I just want to share that I had a blast at #positconf2025! Met so many wonderful people, and gave a talk for the first time. It was awesome!
Reposted by Flávia E. Rius
I’m new to bluesky,so.. hi!
I’m Beatriz / Bea, from Brasil, and currently I’am a post doc researcher.
I started to learn how to program in R in 2018 to use it on my research, and have been programming since then.
I have a blog where I post and share presentations etc
beamilz.com
#rstats 👋
I’m Beatriz / Bea, from Brasil, and currently I’am a post doc researcher.
I started to learn how to program in R in 2018 to use it on my research, and have been programming since then.
I have a blog where I post and share presentations etc
beamilz.com
#rstats 👋
Content – Beatriz Milz
beamilz.com
October 29, 2024 at 2:52 AM
I’m new to bluesky,so.. hi!
I’m Beatriz / Bea, from Brasil, and currently I’am a post doc researcher.
I started to learn how to program in R in 2018 to use it on my research, and have been programming since then.
I have a blog where I post and share presentations etc
beamilz.com
#rstats 👋
I’m Beatriz / Bea, from Brasil, and currently I’am a post doc researcher.
I started to learn how to program in R in 2018 to use it on my research, and have been programming since then.
I have a blog where I post and share presentations etc
beamilz.com
#rstats 👋
I have just experienced the magic of rv in recovering my R packages after having to format my laptop.
Completely recommend!
github.com/A2-ai/rv
#rstats
Completely recommend!
github.com/A2-ai/rv
#rstats
GitHub - A2-ai/rv
Contribute to A2-ai/rv development by creating an account on GitHub.
github.com
August 24, 2025 at 3:37 PM
I have just experienced the magic of rv in recovering my R packages after having to format my laptop.
Completely recommend!
github.com/A2-ai/rv
#rstats
Completely recommend!
github.com/A2-ai/rv
#rstats
Every #Rstats user should read this post from @jennybryan.bsky.social.
Especially beginner to intermediate-level ones.
www.tidyverse.org/blog/2017/12...
Especially beginner to intermediate-level ones.
www.tidyverse.org/blog/2017/12...
Project-oriented workflow
Advice on workflows for developing R scripts. How to think about whether an action belongs in the script or elsewhere.
www.tidyverse.org
August 1, 2025 at 8:37 PM
Every #Rstats user should read this post from @jennybryan.bsky.social.
Especially beginner to intermediate-level ones.
www.tidyverse.org/blog/2017/12...
Especially beginner to intermediate-level ones.
www.tidyverse.org/blog/2017/12...
Reposted by Flávia E. Rius
My biggest, loudest job application advice:
WHY do you want this job? This SPECIFIC job? What about it interests you? What do you think of it? What can you bring to it?
I know this sounds obvious but a generic cover letter isn't doing you favours - really. *Show me you know the job!*
1/7
WHY do you want this job? This SPECIFIC job? What about it interests you? What do you think of it? What can you bring to it?
I know this sounds obvious but a generic cover letter isn't doing you favours - really. *Show me you know the job!*
1/7
July 25, 2025 at 12:09 PM
My biggest, loudest job application advice:
WHY do you want this job? This SPECIFIC job? What about it interests you? What do you think of it? What can you bring to it?
I know this sounds obvious but a generic cover letter isn't doing you favours - really. *Show me you know the job!*
1/7
WHY do you want this job? This SPECIFIC job? What about it interests you? What do you think of it? What can you bring to it?
I know this sounds obvious but a generic cover letter isn't doing you favours - really. *Show me you know the job!*
1/7
Reposted by Flávia E. Rius
1/ When should you use a package vs. solving from scratch in bioinformatics?
I get asked this all the time. Here’s my approach: 👇
I get asked this all the time. Here’s my approach: 👇
July 10, 2025 at 1:15 PM
1/ When should you use a package vs. solving from scratch in bioinformatics?
I get asked this all the time. Here’s my approach: 👇
I get asked this all the time. Here’s my approach: 👇
TIL the parameter .before in mutate() from {dplyr}.
It adds the new column(s) created to the *beginning* of the dataframe, instead of to the end. Quite useful!
Source: #RforDataScience (2e)
(sometimes you should read stuff you think you already know)
#rstats
It adds the new column(s) created to the *beginning* of the dataframe, instead of to the end. Quite useful!
Source: #RforDataScience (2e)
(sometimes you should read stuff you think you already know)
#rstats
July 7, 2025 at 7:40 PM
TIL the parameter .before in mutate() from {dplyr}.
It adds the new column(s) created to the *beginning* of the dataframe, instead of to the end. Quite useful!
Source: #RforDataScience (2e)
(sometimes you should read stuff you think you already know)
#rstats
It adds the new column(s) created to the *beginning* of the dataframe, instead of to the end. Quite useful!
Source: #RforDataScience (2e)
(sometimes you should read stuff you think you already know)
#rstats
Reposted by Flávia E. Rius
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The forgotten half of scientific thinking | PNAS
The forgotten half of scientific thinking
www.pnas.org
June 26, 2025 at 1:23 PM
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Use "export" + the variable name and value when creating a chain of bash scripts, for it to be available in the called script too.
For example:
export LD_CORRELATION=0.2
bash run_ld_correlation_reference.sh
bash run_ld_correlation_samples.sh
#bioinformatics
For example:
export LD_CORRELATION=0.2
bash run_ld_correlation_reference.sh
bash run_ld_correlation_samples.sh
#bioinformatics
June 11, 2025 at 4:10 PM
Use "export" + the variable name and value when creating a chain of bash scripts, for it to be available in the called script too.
For example:
export LD_CORRELATION=0.2
bash run_ld_correlation_reference.sh
bash run_ld_correlation_samples.sh
#bioinformatics
For example:
export LD_CORRELATION=0.2
bash run_ld_correlation_reference.sh
bash run_ld_correlation_samples.sh
#bioinformatics
Reposted by Flávia E. Rius
I think prenatal genetic testing should become part of IVF. The cost of even a single embryo mix up is enormous. NIPT (for parental relatedness) is affordable and can be done early during pregnancy. Parents must have assurance about their child.
thenightly.com.au/australia/mo...
thenightly.com.au/australia/mo...
Monash IVF admits second major embryo mix up
Reproductive giant Monash IVF has released a statement confirming a second major mishap where a woman received the wrong embryo.
thenightly.com.au
June 10, 2025 at 12:32 PM
I think prenatal genetic testing should become part of IVF. The cost of even a single embryo mix up is enormous. NIPT (for parental relatedness) is affordable and can be done early during pregnancy. Parents must have assurance about their child.
thenightly.com.au/australia/mo...
thenightly.com.au/australia/mo...
Quick #bioinformatics tip:
If you'll use plink files in your pipeline, whenever possible, transform your VCF into pgen or bgen ASAP!
Plink files are much faster to work with.
If you'll use plink files in your pipeline, whenever possible, transform your VCF into pgen or bgen ASAP!
Plink files are much faster to work with.
June 6, 2025 at 7:46 PM
Quick #bioinformatics tip:
If you'll use plink files in your pipeline, whenever possible, transform your VCF into pgen or bgen ASAP!
Plink files are much faster to work with.
If you'll use plink files in your pipeline, whenever possible, transform your VCF into pgen or bgen ASAP!
Plink files are much faster to work with.
I need to say that Lonely Planet is still better than chatGPT to find interesting attractions for a trip.
June 5, 2025 at 11:28 PM
I need to say that Lonely Planet is still better than chatGPT to find interesting attractions for a trip.
I have the impression, when reading papers from the 1990's and before, that concepts were explained more clearly than nowadays.
May 27, 2025 at 6:34 PM
I have the impression, when reading papers from the 1990's and before, that concepts were explained more clearly than nowadays.
Today I went to the weekly seminar of the department I do my postdoc in (FMUSP), mostly remotely.
It was great to interact with other researchers in-person. I miss this sometimes.
It was great to interact with other researchers in-person. I miss this sometimes.
May 22, 2025 at 9:44 PM
Today I went to the weekly seminar of the department I do my postdoc in (FMUSP), mostly remotely.
It was great to interact with other researchers in-person. I miss this sometimes.
It was great to interact with other researchers in-person. I miss this sometimes.