Avi Flamholz
@flamholz.bsky.social
NYC; Lab of Environmental Microbiology @rockefelleruniv.bsky.social
Glad you take a conservative approach. Certainly in favor of doing these sorts of assessments when the questions/data take you there (e.g., fig 6 of ref below). Still, seems to me there are many conceptual and statistical issues that are often ignored...
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
October 9, 2025 at 4:19 PM
Glad you take a conservative approach. Certainly in favor of doing these sorts of assessments when the questions/data take you there (e.g., fig 6 of ref below). Still, seems to me there are many conceptual and statistical issues that are often ignored...
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
I see. I think this is a good strategy. I agree that KEGG is super useful, but I still don't really understand how we know which genes go in which pathways.
October 8, 2025 at 8:36 PM
I see. I think this is a good strategy. I agree that KEGG is super useful, but I still don't really understand how we know which genes go in which pathways.
Seems like it would be really hard to control these analyses for multiple hypothesis testing, no?
October 6, 2025 at 7:28 PM
Seems like it would be really hard to control these analyses for multiple hypothesis testing, no?