F. Javier de Haro Arbona
@fjavierdha.bsky.social
Postdoc working in the Santos/Quantitative Stem Cell Group at the Francis Crick Institute.
Reposted by F. Javier de Haro Arbona
Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell!
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
December 1, 2025 at 7:17 PM
Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell!
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
Reposted by F. Javier de Haro Arbona
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Reposted by F. Javier de Haro Arbona
Cool work from Sarah Bray's lab at Cambridge looking at Notch-induced transcription hubs:
www.biorxiv.org/content/10.1...
from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.
www.biorxiv.org/content/10.1...
from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.
July 7, 2025 at 8:03 PM
Cool work from Sarah Bray's lab at Cambridge looking at Notch-induced transcription hubs:
www.biorxiv.org/content/10.1...
from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.
www.biorxiv.org/content/10.1...
from Fig 5: hubs are stabilized/strengthened when initiation is inhibited and diminished when P300 is inhibited.
Reposted by F. Javier de Haro Arbona
A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏
In our latest video, Silvia Santos and Borzo Gharibi of @santoslab.bsky.social explain how their team developed a new stem cell model of the mature amniotic sac, and why this will allow scientists to study the amniotic sac in more detail.
Watch now 👇
www.youtube.com/watch?v=8yjz...
Watch now 👇
www.youtube.com/watch?v=8yjz...
New Discovery Mimics the Amniotic Sac in 3D
YouTube video by Francis Crick Institute
www.youtube.com
July 4, 2025 at 4:20 PM
A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏
Very proud to be among the authors of this story!
Direct observation of Notch signalling induced transcription hubs mediating gene-expression responses https://www.biorxiv.org/content/10.1101/2025.07.04.663121v1
July 5, 2025 at 9:17 AM
Very proud to be among the authors of this story!
Reposted by F. Javier de Haro Arbona
Big welcome to the lab to physicist turned quantitative biologist Beth Westbrook @bethwestbrook.bsky.social! Beth did her PhD in Jonathan Chubb’s lab at UCL and has been very interested in how fate transitions are coordinated. We are lucky she joined our lab for her postdoc!
June 6, 2025 at 3:50 PM
Big welcome to the lab to physicist turned quantitative biologist Beth Westbrook @bethwestbrook.bsky.social! Beth did her PhD in Jonathan Chubb’s lab at UCL and has been very interested in how fate transitions are coordinated. We are lucky she joined our lab for her postdoc!
So excited for this new chapter and honoured to have been invited to join such a talented team!
Big welcome to new postdoc Javier de Haro Arbona @fjavierdha.bsky.social, developmental biologist at heart and coming from Sarah Bray’s lab in Cambridge! Javier has been very interested in how signals are decoded and fate decisions encoded. We are lucky to have him join our lab!
June 6, 2025 at 3:57 PM
So excited for this new chapter and honoured to have been invited to join such a talented team!
Reposted by F. Javier de Haro Arbona
1/n: Excited to share our new preprint. We find that Dorsal transcription factor hubs exhibit gene-specific biophysical properties that tune transcriptional output. Read here: www.biorxiv.org/content/10.1.... Project was led by amazing graduate student Samantha Fallacaro (not on bsky)
Transcription factor hubs exhibit gene-specific properties that tune expression
The spatial and temporal control of gene expression relies on transcription factors binding to and occupying their target sites. Transcription factor hubs - localized, high-concentration microenvironm...
www.biorxiv.org
April 9, 2025 at 2:31 PM
1/n: Excited to share our new preprint. We find that Dorsal transcription factor hubs exhibit gene-specific biophysical properties that tune transcriptional output. Read here: www.biorxiv.org/content/10.1.... Project was led by amazing graduate student Samantha Fallacaro (not on bsky)