Larissa Fischer
@fislarissa.bsky.social
cognitive neuroscience / doctoral researcher with @anne_maass @dzne.science / paramedic 🌈
5/5 🧳
Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.
Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.
December 17, 2024 at 5:50 PM
5/5 🧳
Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.
Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.
4/5💡
Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.
Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.
December 17, 2024 at 5:50 PM
4/5💡
Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.
Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.
3/5 💡
Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.
Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.
December 17, 2024 at 5:50 PM
3/5 💡
Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.
Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.
2/5 💡
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!
December 17, 2024 at 5:50 PM
2/5 💡
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!
1/5 🔎
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).
December 17, 2024 at 5:50 PM
1/5 🔎
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).
I’m super happy about this project with Anne Maass, Jenna Adams, @sylviavilleneuve.bsky.social and the fantastic PREVENT-AD team!
December 17, 2024 at 5:50 PM
I’m super happy about this project with Anne Maass, Jenna Adams, @sylviavilleneuve.bsky.social and the fantastic PREVENT-AD team!