@fillouxlab.bsky.social
Pinned
Happy to be on bsky and to introduce my @SCELSE group in Singapore @NTU and working on #T6SS #Biofilm #c-di-GMP #Pseudomonas #antibiotics From left to right Sujatha, Casandra, Yu Fen, Kay, Qiu Ting and Peggy. They are brilliant so stay tune and follow.
Reposted
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23 | Journal of Natural Products pubs.acs.org/doi/full/10....
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23
Natural products derived from symbiotic microbes remain a rich source of structurally diverse and bioactive molecules. In this study, we report de novo genome sequencing of the termite-associated iso...
pubs.acs.org
November 11, 2025 at 7:24 PM
Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated Micromonospora sp. RB23 | Journal of Natural Products pubs.acs.org/doi/full/10....
Reposted
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system - Nature Communications
Bacteria use the type III secretion system (T3SS) to inject proteins into target cells. Here, Brianceau et al. show that a core structural component, SctD, exchanges between a T3SS-bound and a freely ...
www.nature.com
November 11, 2025 at 9:28 PM
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
#MicrobiologyMonday: Bacteria swarm, but DYK they also "swash"? This flagella-independent movement is tied to fermentation: as cells ferment sugars, they create local osmolarity gradients, which generate a wave of fluid driving expansion. #JBacteriology: asm.social/2Gh
November 10, 2025 at 5:03 PM
#MicrobiologyMonday: Bacteria swarm, but DYK they also "swash"? This flagella-independent movement is tied to fermentation: as cells ferment sugars, they create local osmolarity gradients, which generate a wave of fluid driving expansion. #JBacteriology: asm.social/2Gh
Reposted
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Read more in the eLife Insight Article: buff.ly/1mIc6m0
Read more in the eLife Insight Article: buff.ly/1mIc6m0
November 10, 2025 at 11:28 PM
The pathogenic bacteria Shigella avoids detection inside host cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
Read more in the eLife Insight Article: buff.ly/1mIc6m0
Read more in the eLife Insight Article: buff.ly/1mIc6m0
With Kevin Pethe for a night celebration of the LKCMedicine @NTU 15th anniversary celebration.
November 10, 2025 at 1:02 AM
With Kevin Pethe for a night celebration of the LKCMedicine @NTU 15th anniversary celebration.
Reposted
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oyN3wc
go.nature.com/4oyN3wc
Powerful new antibiotic that can kill superbugs discovered in soil bacteria
Nature - Surprise discovery could pave the way for new treatments against drug-resistant infections.
go.nature.com
November 9, 2025 at 3:09 PM
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oyN3wc
go.nature.com/4oyN3wc
Reposted
The hitchhiker’s guide to cross-species DNA delivery
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
The hitchhiker’s guide to cross-species DNA delivery
Microbial hitchhikers are rewriting the rules of horizontal gene transfer. He, Patkowski,
et al. reveal how phage satellites assemble chimeric infective particles that deliver
DNA across species bound...
www.cell.com
November 9, 2025 at 9:39 AM
The hitchhiker’s guide to cross-species DNA delivery
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social Spotlight by Kotaro Kiga and Rodrigo Ibarra-Chávez
www.cell.com/trends/micro...
Reposted
Postdoc grant submitted, time to gets back in conference mood with @evolvedbiofilm.bsky.social highlighting the magic of Bacillus #PMS2025
November 6, 2025 at 2:03 PM
Postdoc grant submitted, time to gets back in conference mood with @evolvedbiofilm.bsky.social highlighting the magic of Bacillus #PMS2025
Reposted
The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response - Nature Communications
In this work, authors show that Salmonella uses its SPI-1 injectisome to infect macrophages, triggering rapid translational upregulation of transcription factors, such as EGR1 which suppresses the inf...
www.nature.com
November 5, 2025 at 3:57 PM
The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
E. coli can spread as quickly as swine flu, new research reveals. 🦠
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
Advanced disease modelling shows some gut bacteria can spread as rapidly as viruses
Experts can now predict the transmission rate of a bacterial E. coli infection in the same way as they can for viral pandemics, which can help battling treatment-resistant infections in the future.
sanger.ac.uk
November 4, 2025 at 11:55 AM
E. coli can spread as quickly as swine flu, new research reveals. 🦠
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
Reposted
M. smegmatis uses new types of biofilm to enclose a liquid core and expand outwards in a weird new way.
October 30, 2025 at 8:30 PM
M. smegmatis uses new types of biofilm to enclose a liquid core and expand outwards in a weird new way.
Reposted
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
November 2, 2025 at 7:13 PM
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
Reposted
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
November 1, 2025 at 12:41 PM
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
Reposted
Soil organic carbon-microbiome axis:
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon mediates plant immunity-rhizosphere microbiome interactions and controls colonization resistance to microbial inoculants
Huang et al. report that soil organic carbon (SOC) influences microbial inoculant
performance, with wheat yield responses peaking at intermediate SOC. At these levels,
shifts in plant immunity and mic...
www.cell.com
October 30, 2025 at 3:28 PM
Soil organic carbon-microbiome axis:
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Soil organic carbon(SOC) influences microbial inoculant performance, w/wheat yield responses peaking at intermediate SOC. At these levels, shifts in plant immunity & microbial interactions shape rhizosphere colonization
www.cell.com/cell-host-mi...
Reposted
New in JB: Perslow, Meadows-Graves & Luallen explore the role the virulence regulator bvgS in control of nutrient-induced filamentation by B. avium - this morphological change may be a general feature of Bordetellae.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
October 29, 2025 at 1:25 PM
New in JB: Perslow, Meadows-Graves & Luallen explore the role the virulence regulator bvgS in control of nutrient-induced filamentation by B. avium - this morphological change may be a general feature of Bordetellae.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
Reposted
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted
Catalog of human oral microbiome:
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights
Oral microbiome shows rising importance in human health. Cha et al. present the human
reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426
species, including 2,019 previ...
www.cell.com
October 29, 2025 at 7:06 PM
Catalog of human oral microbiome:
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases
www.cell.com/cell-host-mi...
Reposted
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex
Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...
journals.plos.org
October 28, 2025 at 1:25 AM
Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...
Reposted
Reposted
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
doi.org
October 22, 2025 at 9:40 PM
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Reposted
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
Reposted
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications
Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.
bit.ly
October 21, 2025 at 2:51 PM
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Reposted
With the functional link!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
New in JB: Bhattacharya, Zhang, & Yu review the current state of knowledge around protein trafficking across the membrane by gram-positive bacteria with a focus on the model organisms Bacillus subtilis and Staphylococcus aureus.
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org
#JBacteriology
October 21, 2025 at 2:04 PM
With the functional link!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
October 15, 2025 at 1:07 PM
#microsky #mevosky @spp2389.bsky.social
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT
A PhD position is available in my lab to work on:
Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria.
Please RT
Deadline: 12.11.25
More infos 👇
shorturl.at/rAKAT