Shu-Sin Chng
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figlegend.bsky.social
Shu-Sin Chng
@figlegend.bsky.social
390 followers 310 following 67 posts
Assoc Professor @ National University of Singapore. 🇸🇬 NUS Assoc Dir for SCELSE. Membrane/lipid biochemist. Educator who teaches chemistry in biology. Advocate (Vice Dean) for students. Horn player. 📯📯

https://chemistry.nus.edu.sg/people/chng-shu-sin/
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figlegend.bsky.social
Shu-Sin Chng @figlegend.bsky.social · Jun 17
Super excited to share our latest work revealing impt of protein-lipid interactions for the pri fn of the Tol-Pal complex in maintaining outer memb lipid homeostasis in E. coli! Huge discovery by Nadege Lim in collab @pstansfeld.bsky.social @robincorey.bsky.social 1/7
www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted by Shu-Sin Chng
pstansfeld.bsky.social
Kat Blow has developed CCD2MD, a suite of packages for preparing co-folded outputs for MD simulations.

Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too.

pubs.acs.org/doi/full/10....

github.com/keb721/ccd2md
CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations
Protein–lipid interactions play a crucial role in the stability and function of membrane proteins. While experimental approaches to characterize these interactions in a native-like membrane environmen...
pubs.acs.org
November 12, 2025 at 11:53 AM
Reposted by Shu-Sin Chng
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Shu-Sin Chng
johnrubinstein.bsky.social
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex
October 30, 2025 at 3:21 AM
Reposted by Shu-Sin Chng
klanglab.bsky.social
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...

it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
Reposted by Shu-Sin Chng
friendlymicrobe.bsky.social
PhD opportunity in my lab: exploring how commensals and pathogens build biofilm communities on endotracheal (ventilator) tubes. Microbial ecology, medical microbiology and fancy imaging! Co-supervised with the fabulous Saskia Bakker and Jeremy Webb warwick.ac.uk/fac/cross_fa... #MicroSky
Dr Freya Harrison
Dr Freya Harrison
warwick.ac.uk
October 15, 2025 at 8:09 PM
Reposted by Shu-Sin Chng
lizmillercu.bsky.social
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.

www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Reposted by Shu-Sin Chng
biorxiv-microbiol.bsky.social
Persistent LPS insertion, spatial segregation and vesicle biogenesis drive growth-independent adaptation of the Escherichia coli outer membrane https://www.biorxiv.org/content/10.1101/2025.10.09.681453v1
October 10, 2025 at 3:16 AM
figlegend.bsky.social
We are back for #SGBUG for Oct, with Shaun Tan from Benson Chen's grp at GIS A*STAR, and Jason Chen from Chris Sham's grp at NUS ID-TRP, sharing about genetic manipulation in gut commensals, and glycoengineering in S. pneumoniae, respectively!
October 9, 2025 at 9:50 AM
Reposted by Shu-Sin Chng
sykhalid.bsky.social
Come join us in Oxford! Two positions open right now in @oxfordbiochemistry.bsky.social
It’s a great place to work. Really supportive colleagues, great students, colleges provide a unique social environment - in summary, it’s a lot of fun.
tobiaswarnecke.bsky.social Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 29
Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
October 1, 2025 at 7:12 AM
Reposted by Shu-Sin Chng
paulhoskisson.bsky.social
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
www.gla.ac.uk
September 30, 2025 at 11:02 AM
Reposted by Shu-Sin Chng
bugsinblood.bsky.social
Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
September 29, 2025 at 2:24 PM
Reposted by Shu-Sin Chng
lalouxlab.bsky.social
📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
www.biorxiv.org
September 25, 2025 at 7:12 AM
Reposted by Shu-Sin Chng
veeninglab.com
Nice work on tackling genetic interactions in the pneumococcus! If you like this, you will also like our work doing the same thing using dual CRISPRi. Coming soon in @cp-cellsystems.bsky.social www.biorxiv.org/content/10.1...
September 26, 2025 at 7:07 AM
Reposted by Shu-Sin Chng
campy-bara.bsky.social
Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science www.science.org/doi/10.1126/...
Dual transposon sequencing profiles the genetic interaction landscape in bacteria
Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...
www.science.org
September 25, 2025 at 11:19 PM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...
September 22, 2025 at 11:38 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.

www.marles-wright-lab.org
September 22, 2025 at 12:10 PM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
The @henrikstrahl.bsky.social group focuses on bacterial cell envelopes and envelope-targeting antibiotics.
Using cell biology, high-end fluorescence microscopy, genetics, and biochemistry, they study the function, biosynthesis and organisation of bacterial cell membranes.

strahllab.weebly.com
September 23, 2025 at 8:58 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
Dr Alistair Brown’s group is interested in mycobacterial biology, focusing on antimicrobial drug discovery and elucidation of drug mechanisms of action. They aim to understand how existing and novel compounds affect mycobacterial growth, survival, and persistence.

@mycobacterium-ncl.bsky.social
September 23, 2025 at 9:10 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
Dr Chien-Yi Chang's lab studies how Gram-negative bacteria sense and respond to different environments using molecular and bioimaging approaches.

👉 @davychang.bsky.social

chienyichang.wixsite.com/changlab
September 23, 2025 at 9:14 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
The Salgado group focuses on structural and functional characterisation of proteins involved in pathogenicity pathways in C. difficile. They are particularly interested in S-layer and sporulation proteins and their role in infection.

Follow @pssalgado.bsky.social

salgadolab.org
September 23, 2025 at 10:00 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
Next up,

Dr Kate Beckham @kshbeckham.bsky.social

The Beckham lab is interested mycobacterial membrane transport processes. They focusing on understanding the steps occurring at the mycobacterial outer membrane.

www.ncl.ac.uk/cbcb/staff/p...
September 23, 2025 at 8:53 AM
Reposted by Shu-Sin Chng
mhd-newcastle.bsky.social
Day 2 of MHD introductions 😃

Dr Lis Lowe @lislowe.bsky.social

The Lowe lab is focussed on microbial glycobiology. They work on bacterial Cazymes from commensals and pathogens, and are particularly interested in enzymes that target microbial glycans such as the cell walls of Mycobacteria.
September 23, 2025 at 8:41 AM
Reposted by Shu-Sin Chng
scelse.bsky.social
Check out this talk on 30 Sep 2025 - Tackling the global spread of AMR using genome-resolved metagenomics and Al - by Dr Niranjan Nagarajan, and hosted by @fillouxlab.bsky.social
September 24, 2025 at 9:13 AM
Reposted by Shu-Sin Chng
friendlymicrobe.bsky.social
A colleague received proofs of an accepted manuscript, and the "proofing process" clearly involved running the text through ChatGPT. Their voice has been erased, and errors introduced. This is from a supposedly reputable publisher. Anyone else been put through this particular form of hell? #MicroSky
September 24, 2025 at 12:19 PM
Reposted by Shu-Sin Chng
wilbertbitter.bsky.social
PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this
PPE51 modulates membrane integrity in Mycobacterium marinum | mBio
The impermeable outer membrane of pathogenic mycobacteria presents a major obstacle to nutrient acquisition and antibiotic penetration. PPE51, a substrate of the ESX-5 secretion system, has previously...
journals.asm.org
September 23, 2025 at 7:48 AM